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Chris Meisinger Profile Page
Chris Meisinger


Lab: Prof. Dr. Chris Meisinger
Department: Institute of Biochemistry and Molecular Biology and
BIOSS Centre for Biological Signalling Studies
Phone: +49 761 203 5287
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster : Member
PhD positions available: YES
Research Area: Synthetic Biology and Signalling
Research Interests: Signaltransduction in mitochondrial protein import,
Mitochondrial signal switches in tumor diseases,
Mitochondrial protein quality control in Alzeimer’s disease


Education & Training: 1987-1993: Diploma in Chemistry at Albert-Ludwigs-University Freiburg, Germany
1997: Dr. rer. nat. in Chemistry at Albert-Ludwigs-University Freiburg, Germany
Employment & Experience: 1997-98: Post Doc Institute for Anatomy and Cellbiology, Albert-Ludwigs-University Freiburg
1998-2000: Post Doc Institute for Biochemistry and Molecularbiology, Albert-Ludwigs-University Freiburg
2000-2009: Group leader, Institute for Biochemistry and Molecularbiology, Albert-Ludwigs-University Freiburg, Germany.
since 2009: Professor at the Institute of Biochemistry and Molecularbiology and the
Centre of Biological Signalling Studies (bioss), University of Freiburg
2010-2012: Visiting research Professor, University of Bern, Switzerland
Scientific Activities: Since 2001: ad hoc referee for scientific journals (e.g. Science, Nature Commun., Science Signal., Mol. Cell. Biol., EMBO Rep., EMBO J., Nature, Cell, Mol. Biol. Cell, Exp. Cell Res., J. Biol. Chem., J. Proteome Res., Mol. Cell. Proteomics, BMC Biology, Dev. Cell, Cell Metab., PNAS, FEBS J.)
Since 2003: ad hoc referee for e.g. Deutsche Forschungsgemeinschaft (DFG), the Human Frontier Science Program and the National Science Foundation (NSF), USA, Israel Science Foundation (ISF), Czech Science Foundation, European Research Council (ERC), Studienstiftung des Deutschen Volkes, Alexander von Humboldt-Stiftung, Deutsche Akademische Austauschdienst (DAAD)
2007: Habilitation in Biochemistry and Molecularbiology
2012-present: Member of the Executive Board of the Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Germany
2013-present: Founding editorial board member Microbial Cell


Honors and Awards:

2001-2006: Principle investigator in the SFB 388
2002-2006: DFG-Projectleader (ME 1921/1-1 and 1-2) for analysis of the mitochondrial proteome
2005: Eugen-Graetz research award for discovery of the SAM-complex
2007-present: Principle investigator in the Spemann Graduate School of Biology and Medicine (SGBM);
2009-present: Principle investigator in the excellence cluster BIOSS
2008-present: Principle investigator of the International Research Training Group ‘Membrane Proteins and Biological Membranes’
2010-2013: DFG-Projectleader (ME 1921/2-1) for analysis of the mitochondrial outer membrane permeome.
2010-2013: Projectleader in the BMBF SysTec research cluster DYNAMO
2014-present: DFG-Projectleader (ME 1921/4-1) for analysis of phosphorylation in regulation of mitochondrial protein import
2003-present: Constant top ten position of best lecturers (annual evaluation by students of human medicine)
2007: 1. NaT-Working award (50.000.- €) of the Robert-Bosch-Stiftung for collaboration between university and schools (together with Dr. J. Brix)
2009: Ranked Pos. 12 of best-cited scientists (Cell biology) in german-speaking countries (Laborjournal 12/2009)
2012: Best lecturer in Molecular Medicine (evaluation by the B.S. students of Molecular Medicine)
1995-present: 99 peer reviewed publications; h-Index: 45


Selected Publications:

Opalińska, M. and Meisinger, C. (2015). Metabolic control via the mitochondrial protein import machinery. Curr. Opin. Cell Biol. 33, 42-48. Abstract

Mossmann, D., Vögtle, F.N., Taskin, A.A., Teixeira, P.F., Ring, J., Burkhart, J.M., Burger, N., Pinho, C.M., Tadic, J., Loreth, D., Graff, C., Metzger, F., Sickmann, A., Kretz, O., Wiedemann, N., Zahedi, R.P., Madeo, F., Glaser E. and Meisinger, C. (2014). Amyloid-beta peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab. 20, 662-669. Abstract

Harbauer, A.B., Opalinska, M., Gerbeth, C., Herman, J.S., Rao, S., Schönfisch, B., Guiard, B., Schmidt, O., Pfanner, N., and Meisinger, C. (2014). Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science 346, 1109-1113. Abstract

Vögtle, F.N., Burkhart, J.M., Rao, S., Gerbeth, C., Hinrichs, J., Martinou, J.C., Chacinska, A., Sickmann, A., Zahedi, R.P., and Meisinger, C. (2012). Intermembrane space proteome of yeast mitochondria. Mol. Cell. Proteomics 11, 1840-1852. Abstract

Schmidt, O., Harbauer, A.B., Rao, S., Eyrich, B., Zahedi, R.P., Stojanovski, D., Schönfisch, B., Guiard, B., Sickmann, A., Pfanner, N., and Meisinger, C. (2011). Regulation of mitochondrial protein import by cytosolic kinases. Cell 144, 227-239. Abstract

Vögtle, F.N., Wortelkamp, S., Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N., and Meisinger, C. (2009). Global analysis of the mitochondrial N-Proteome identifies a processing peptidase critical for protein stability. Cell 139, 428-439. Abstract

Meisinger, C., Sickmann, A., and Pfanner, N. (2008). The mitochondrial proteome: from inventory to function. Cell 134, 22-24. Abstract

Reinders, J., Wagner, K., Zahedi, M.P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., and Meisinger, C. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol. Cell. Proteomics 6, 1896-1906. Abstract

Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N. and Meisinger, C. (2003). The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. USA 100, 13207-13212. Abstract

Wiedemann, N., Kozjak, V., Chacinska, A., Schönfisch, B., Rospert, S., Ryan, M.T., Pfanner, N., and Meisinger, C. (2003). Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424, 565-571. Abstract

SGBM PhD students

SGBM PhD students:


Track 1:
Ruonan Zhai (04/2010 - 02/2016)
Asli Aras-Taskin (04/2011 - 11/2015)

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