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Nils Wiedemann Profile Page
Nils Wiedemann


Lab: PD Dr. Nils Wiedemann
Department: Institute of Biochemistry and Molecular Biology
Phone: 203 5280
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster : Project leader
PhD positions available: YES
Research Area: Protein Structure and Function
Research Interests: Mitochondrial biogenesis and sorting of mitochondrial membrane proteins.


Education & Training: 1993-1995: Prediploma in Chemistry, Johann Wolfgang Goethe-University Frankfurt, Germany

1995-1999: Diploma in Chemistry, Albert-Ludwigs-University Freiburg, Germany

1996-1997: Master classes in Biochemistry, Cell Biology & Molecular Biology, University of Massachusetts, Amherst, USA

2002: Dr. rer. nat., Faculty of Biology, Albert-Ludwigs-University Freiburg, Germany

2010: Habilitation, Faculty of Medicine, Albert-Ludwigs-University Freiburg, Germany
Employment & Experience: 2001: Yeast Genetics Course, Cold Spring Harbor Laboratory, USA

2002-2004: Postdoctoral Fellow in Biochemistry, University of Freiburg

2004-2010: Group leader, Institute for Biochemistry and Molecular Biology, University of Freiburg

2006: Visiting Scientist, La Trobe University, Melbourne, Australia

2010: Privatdozent (Habilitation), Faculty of Medicine, University of Freiburg

2013: Academic director, Institute for Biochemistry and Molecular Biology, University of Freiburg
Scientific Activities: 2000-present: Member of the German Society for Biochemistry and Molecular Biology (GBM), Frankfurt, Germany

2012-present: Project leader of the Excellence Cluster Centre of Biological Signalling Studies (BIOSS), University of Freiburg

2015-present: Member of Collaborative Research Centre ‘Kidney Disease - from Genes to Mechanisms’ (KIDGEM, SFB 1140), University of Freiburg


Honors and Awards:
2015: ERC consolidator grant
2001: Fellowship of the scientific society Freiburg for participation in the yeast genetics course, Cold Spring Harbor Laboratory, USA
2002: Summa cum laude, University of Freiburg
2003: PhD Award ‘Hans Grisebach Dissertationspreis’, Faculty of Biology, University of Freiburg
2007: Young Investigator Award, German Society for Biochemistry and Molecular Biology (GBM), Frankfurt
2011: Eugen-Graetz-Price for Research, Faculty of Medicine, University of Freiburg


Selected Publications:

Qiu, J., Wenz, L.S., Zerbes, R.M., Oeljeklaus, S., Bohnert, M., Stroud, D.A., Wirth, C., Ellenrieder, L., Thornton, N., Kutik, S., Wiese, S., Schulze-Specking, A., Zufall, N., Chacinska, A., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N.*, Wiedemann, N.*, Becker, T. (2013) Coupling of Mitochondrial Import and Export Translocases by Receptor-Mediated Supercomplex Formation. Cell. 154, 596–608. (* corresponding)  Abstract

Gebert, N., Gebert, M., Oeljeklaus, S., von der Malsburg, K., Stroud, D.A., Kulawiak, B., Wirth, C., Zahedi, R.P., Dolezal, P., Wiese, S., Simon, O., Schulze-Specking, A., Truscott, K.N., Sickmann, A., Rehling, P., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N., Wiedemann, N. (2011) Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane. Mol Cell. 44, 811–818. Abstract

Stroud, D.A., Oeljeklaus, S., Wiese, S., Bohnert, M., Lewandrowski, U., Sickmann, A., Guiard, B., van der Laan, M., Warscheid, B., Wiedemann, N. (2011) Composition and topology of the endoplasmic reticulum-mitochondria encounter structure. J Mol Biol. 413, 743–750. Abstract

Kutik, S., Stojanovski, D., Becker, L., Becker, T., Meinecke, M., Krüger, V., Prinz, C., Meisinger, C., Guiard, B., Wagner, R., Pfanner, N. and Wiedemann, N. (2008) Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell. 132, 1011-1024. Abstract

Kutik, S., Rissler, M., Guan, X.L., Guiard, B., Shui, G., Gebert, N., Heacock, P.N., Rehling, P., Dowhan, W., Wenk, M.R., Pfanner, N., Wiedemann, N. (2008) The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J Cell Biol. 183, 1213–1221. Abstract

Gebert, N., Chacinska, A., Wagner, K., Guiard, B., Koehler, C.M., Rehling, P., Pfanner, N. and Wiedemann, N. (2008) Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase. EMBO Rep. 9, 548-554. Abstract

Becker, T., Pfannschmidt, S., Guiard, B., Stojanovski, D., Milenkovic, D., Kutik, S., Pfanner, N., Meisinger, C. and Wiedemann, N. (2008) Biogenesis of the Mitochondrial TOM Complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J Biol Chem. 283, 120-127. Abstract

Meisinger, C., Pfannschmidt, S., Rissler, M., Milenkovic, D., Becker, T., Stojanovski, D., Youngman, M.J., Jensen, R.E., Chacinska, A., Guiard, B., Pfanner, N. and Wiedemann, N. (2007) The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J. 26, 2229-2239. Abstract

Wiedemann, N., Urzica, E., Guiard, B., Müller, H., Lohaus, C., Meyer, H.E., Ryan, M.T., Meisinger, C., Mühlenhoff, U., Lill, R. and Pfanner, N. (2006) Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J. 25, 184-195. Abstract

Wiedemann, N., Kozjak, V., Chacinska, A., Schönfisch, B., Rospert, S., Ryan, M.T., Pfanner, N. and Meisinger, C. (2003) Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature. 424, 565-571. Abstract

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