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Marco Prinz Profile Page
Marco Prinz


Lab: Prof. Dr. Marco Prinz
Department: Director of the Institute of Neuropathology
University Medical Center
Address: Breisacher Straße 64
79106 Freiburg
Phone: +49 761 270 51050
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster : Associated Member
PhD positions available: YES
Research Interests: Brain-specific immune functions during health and disease (autoimmune and neurodegenerative CNS disorders). Fate of microglia in the brain. Role of type I interferons in autoimmune inflammation. Origin and function of microglia.


Education & Training: 1990-1966 MD at Humboldt University (Charité), Berlin
2004 Consultant in the field of Neuropathology, Georg-August University, Göttingen, Germany
2004 Habilitation in the field of Neuropathology, Georg-August University, Göttingen, Germany
Employment & Experience: 1996-97: Medical doctor (AiP) at the department of neurology at Charité (head: Prof. Einhäupl)
1997-98: Postdoc position at Max-Delbrück-Center (MDC) Berlin, Cellular Neurosciences (head: Prof. Kettenmann)
1999-00: Postdoctoral fellow (DFG fellowship) at the Institute of Neuropathology (head: Prof.Aguzzi), University of Zurich, Switzerland
2001-02: Senior research postdoc at the Institute of Neuropathology (head: Prof.Aguzzi), University of Zurich, Switzerland
2002-08: Group leader at the Institute of Neuropathology (head: Prof. Brück), University of Göttingen
2004-present: Lecturer (“Habilitation”) and consultant (“Facharzt” and “Oberarzt”) in neuropathology
2008-present: Director (W3), Department of Neuropathology, University Freiburg
Scientific Activities: 2008-present Editorial Board: GLIA
2010-present Co-Speaker; DFG-FOR (Research Unit) 1336
2011 Guest Editor, GLIA Special Issue
Ad hoc referee duties for the journals Blood, Brain, Journal of Experimental Medicine, Nature Biotechnology, Nature Medicine, Nature Neuroscience, PNAS, Science, among others.


Honors and Awards:

1989    Erich Correns Prize (National Society of Chemistry)
2004    H.G. Creutzfeld Prize (University of Kiel)
2005    Pfizer Research Prize for Medicine (University of Freiburg)
2006    Young Investigator Award, (International Cytokine Society, Vienna)
2007    Hans Georg Queckenstedt Prize (DMSG)



Selected Publications:

Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Hölscher C, Müller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci. 2013 Mar;16(3):273-80. doi: 10.1038/nn.3318. Epub 2013 Jan 20. Abstract

Dann A, Poeck H, Croxford A, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth S, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M (2012) Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation of the CNS. Nat Neurosc, 15:98-106. Abstract

McLaren A, Ransohoff R, Prinz M (2010): Microglial pilgrimage to the brain. Nat Med, 16 (12):1380-1381. Abstract

Mildner A, Mack M, Schmidt H, Brück W, Djukic M, Zabel MD, Hille A, Priller J, Prinz M (2009): CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain, 132(9):2487-500. Abstract

Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwälder M, Brück W, Priller J, Prinz M (2007): Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosc, 10(12):1544-53. incl. news & views. Abstract

Prinz M*, Garbe F, Schmidt, Mildner A, Gutcher I, Wolter K, Piesche M, Schroers R, Weiss E, Kirschning CJ, Rochford CDP, Brück W, Becher B (2006): Innate Immunity mediated by CNS resident cells modulates pathogenicity in an animal model of multiple sclerosis. J Clin Invest, 116(2):456-464. *corresp. Author Abstract

Prinz M, Priller J, Sisodia SS, Ransohoff RM (2011): Microglia in the CNS: Heterogeneity of central nervous system myeloid cells and their roles in neurodegeneration. Nat Neurosc 14(10):1227-35. Abstract

Prinz M*, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Brück W, Kalinke U (2008): Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity, 28(5):675-86. *corresp. author, including cover + news & views. Abstract

Raasch J, Zeller N, Van Loo G, Merkler D, Mildner A, Erny D, Knobeloch KP, Bethea JR, Waisman A, Knust M, DelTurco D, Deller T, Blank T, Priller J, Brück W, Pasparakis M, Prinz M (2011): IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the CNS. Brain, 134(4):1184-98. Abstract

Van Loo G, DeLorenzi R, Schmidt H et al. Prinz M*, Pasparakis M* (2006): NF-κB inhibition in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol, 7(9):954-961. (*contr. equally) including news & views. Abstract

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