Bodo Grimbacher

Bodo Grimbacher Profile Page

Contact

Lab:	Prof. Dr. Bodo Grimbacher
Department:	Institute for Immunodeficiency Center for Chronic Immunodeficiency University Medical Center Freiburg
Address:	Breisacher Str. 115 79106 Freiburg
Phone:	+49 761 270 77732
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.uniklinik-freiburg.de/cci/live/forschung/pis/BodoGrimbacher/Researchareas_en.html
PhD positions available:	YES
Research Area:	Immunology and Virology
Research Interests:	Genetic causes of hypogammaglobulinemia (CVID) The clinical phenotype of antibody deficiency syndromes The genetic cause of the hyper-IgE recurrent infection syndrome (HIES) New disease genes in severe congenital neutropenia (SCN) The genetic cause of chronic mucocutaneous candidiasis (CMC) The molecular pathology of chronic inflammatory bowel disease

CV

Education & Training:	2006: Habilitation: "The Genetic causes of primary antibody deficiencies", University Hospital Freiburg, Prof. Dr. H.H. Peter, Germany 1995 – 1997: Department of Rheumatology and Clinical Immunology, Freiburg, Germany 1992 – 1995: Dissertation: "Activation of early growth response transcripts in rheumatoid synovial fibroblasts", Department of Rheumatology and Clinical Immunology, University Hospital Freiburg, Germany 1988 – 1995: Medical School: Technische Hochschule Aachen, Albert-Ludwigs-University Freiburg and University of Hamburg, Germany
Employment & Experience:	2021–2022: Sabbatical at UCSD, La Jolla, in the laboratory of Prof. Kees Murre, Topic: Epigenetics of B cells Since 2019: Vice Director of the Institute for Immunodeficiency at the CCI, Medical Center – Albert-Ludwigs University, Freiburg 2011–2019: Scientific Director and consultant at the CCI, Medical Center - Albert-Ludwigs University, Freiburg 2006-2011: Consultant and Head of Marie-Curie Research Group, Dept. of Immunology, Royal Free Hospital & University College London, UK 2000-2006: Assistant lecturer, Senior scientist, and Emmy-Nöther-Fellow of the DFG, Department of Rheumatology and Clinical Immunology, Freiburg, Germany 1997-2000: Postdoc, NIH, National Human Genome Institute, Bethesda, MD, USA
Scientific Activities:	Academic Board positions: 2014 – ongoing: Speaker of the Arbeitskreis Klinische Immunologie of the DGfI 2014 – ongoing: Head of the Novartis PI3Kd-inhibitor trial on APDS in Europe 2008 - 2011: Steering Committee of the European Ig-Pro20 immunoglobulin trial 2007 - 2011: Member of the UK-PIN steering committee 2006 - 2010: Secretary of the European Society for Immunodeficiencies (ESID) 2002 - 2006: Head of the ESID Registry Working Party Occasional reviewer for The New England Journal of Medicine, Nature, Journal of Experimental Medicine, Journal of Allergy and Clinical Immunology, and other Journals

Honors

Honors and Awards:

2012 Watson Memorial Lecture, University of Newcastle, UK
2010 Member of London Medical Research Club
2009 Thieme Research Prize of the Leopoldina, Halle
2009 Invitation to join the Henry Kunkel Society
2008 Richard S. Farr Memorial Lectureship at AAAAI
2007 Rudolph-Schoen Prize from the Medizinische Hochschule Hannover
2006 Marie-Curie Excellence Award of the European Commission for 4 years
2006 Election as Secretary for the European Society for Immunodeficiencies
2006 Georges Köhler Award 2006 of the German Immunology Society
2004 Award for the best project within the Freiburg Research Network SFB620
2002 Election to host the Clinical Patient Registry of ESID
2002 Admission to the Emmy Nöther program of the German research foundation
1999 Fellow of the Immunodeficiency Foundation (IDF)
1998 Poster award of NHGRI, NIH
1990 Fellowship of the Hans-Hench-foundation
1983 Fulbright-Fellow

Publications

Selected Publications:

Rauer S, Marks R, Urbach H, Warnatz K, Nath A, Holland S, Weiller C, Grimbacher B. Treatment of Progressive Multifocal Leukoencephalopathy with Pembrolizumab. N Engl J Med. 2019 Apr 25;380(17):1676-1677. Abstract

Frey-Jakobs S, Hartberger JM, Fliegauf M, Bossen C, Wehmeyer ML, Neubauer JC, Bulashevska A, Proietti M, Fröbel P, Nöltner C, Yang L, Rojas-Restrepo J, Langer N, Winzer S, Engelhardt KR, Glocker C, Pfeifer D, Klein A, Schäffer AA, Lagovsky I, Lachover-Roth I, Béziat V, Puel A, Casanova JL, Fleckenstein B, Weidinger S, Kilic SS, Garty BZ, Etzioni A, Grimbacher B. ZNF341 controls STAT3 expression and thereby immunocompetence. Sci Immunol. 2018 Jun 15;3(24):eaat4941. Abstract

Fliegauf M, Bryant VL, Frede N, Slade C, Woon ST, Lehnert K, Winzer S, Bulashevska A, Scerri T, Leung E, Jordan A, Keller B, de Vries E, Cao H, Yang F, Schäffer AA, Warnatz K, Browett P, Douglass J, Ameratunga RV, van der Meer JW, Grimbacher B. Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency. Am J Hum Genet. 2015 Sep 3;97(3):389-403. Abstract

Schubert D, Bode C, Kenefeck R, Hou TZ, Wing JB, Kennedy A, Bulashevska A, Petersen BS, Schäffer AA, Grüning BA, Unger S, Frede N, Baumann U, Witte T, Schmidt RE, Dueckers G, Niehues T, Seneviratne S, Kanariou M, Speckmann C, Ehl S, Rensing-Ehl A, Warnatz K, Rakhmanov M, Thimme R, Hasselblatt P, Emmerich F, Cathomen T, Backofen R, Fisch P, Seidl M, May A, Schmitt-Graeff A, Ikemizu S, Salzer U, Franke A, Sakaguchi S, Walker LSK, Sansom DM, Grimbacher B. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med. 2014 Dec;20(12):1410-1416. Abstract

Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schäffer AA, Noyan F, Perro M, Diestelhorst J, Allroth A, Murugan D, Hätscher N, Pfeifer D, Sykora KW, Sauer M, Kreipe H, Lacher M, Nustede R, Woellner C, Baumann U, Salzer U, Koletzko S, Shah N, Segal AW, Sauerbrey A, Buderus S, Snapper SB, Grimbacher B, Klein C. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009 Nov 19;361(21):2033-45. Abstract

Glocker EO, Hennigs A, Nabavi M, Schäffer AA, Woellner C, Salzer U, Pfeifer D, Veelken H, Warnatz K, Tahami F, Jamal S, Manguiat A, Rezaei N, Amirzargar AA, Plebani A, Hannesschläger N, Gross O, Ruland J, Grimbacher B. A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med. 2009 Oct 29;361(18):1727-35. Abstract

Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, Brodsky N, Freeman AF, Demidowich A, Davis J, Turner ML, Anderson VL, Darnell DN, Welch PA, Kuhns DB, Frucht DM, Malech HL, Gallin JI, Kobayashi SD, Whitney AR, Voyich JM, Musser JM, Woellner C, Schäffer AA, Puck JM, Grimbacher B. STAT3 mutations in the hyper-IgE syndrome. N Engl J Med. 2007 Oct 18;357(16):1608-19. Abstract

Salzer U, Chapel HM, Webster AD, Pan-Hammarström Q, Schmitt-Graeff A, Schlesier M, Peter HH, Rockstroh JK, Schneider P, Schäffer AA, Hammarström L, Grimbacher B. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet. 2005 Aug;37(8):820-8. Abstract

Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, Eibel H, Fischer B, Schäffer AA, Mages HW, Kroczek RA, Peter HH. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol. 2003 Mar;4(3):261-8. Abstract

Grimbacher B, Holland SM, Gallin JI, Greenberg F, Hill SC, Malech HL, Miller JA, O'Connell AC, Puck JM. Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder. N Engl J Med. 1999 Mar 4;340(9):692-702. Abstract

SGBM PhD students

SGBM PhD students:

Elena Sindram (since July 2021)

ALUMNI:
Desirée Schubert (graduated 2017)