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Bodo Grimbacher Profile Page
Bodo Grimbacher

Contact

Lab: Prof. Dr. Bodo Grimbacher
Department: Center of Chronic Immunodeficiency
University Medical Center
Address: Breisacher Str. 115
79106 Freiburg
Phone: +49 761 270 77731
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.uniklinik-freiburg.de/cci/live/forschung/pis/BodoGrimbacher/Researchareas_en.html
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: Genetic causes of hypogammaglobulinemia (CVID)
The clinical phenotype of antibody deficiency syndromes
The genetic cause of the hyper-IgE recurrent infection syndrome (HIES)
New disease genes in severe congenital neutropenia (SCN)
The genetic cause of chronic mucocutaneous candidiasis (CMC)
The molecular pathology of chronic inflammatory bowel disease

CV

Education & Training: 2006: Habilitation: "The Genetic causes of primary antibody deficiencies",
University Hospital Freiburg, Prof. Dr. H.H. Peter, Germany
1995 – 1997: Department of Rheumatology and Clinical Immunology, Freiburg, Germany
1992 – 1995: Dissertation: "Activation of early growth response transcripts in rheumatoid synovial fibroblasts", Department of Rheumatology and Clinical Immunology, University Hospital Freiburg, Germany
1988 – 1995: Medical School: Technische Hochschule Aachen, Albert-Ludwigs-University Freiburg and University of Hamburg, Germany
Employment & Experience: 2011 - present: Scientific Director and consultant of the CCI, Freiburg University
2006 - 2011: Consultant and Head of Marie-Curie Research Group
Dept. of Immunology, Royal Free Hospital & University College London, UK
2000 - 2006: Assistant lecturer, Senior scientist, and Emmy-Nöther-Fellow of the DFG
Department of Rheumatology and Clinical Immunology, Freiburg, Germany
1997 - 2000: Postdoc, NIH, National Human Genome Institute, Bethesda, MD, USA
Scientific Activities: Academic Board positions:
2014 – ongoing: Speaker of the Arbeitskreis Klinische Immunologie of the DGfI
2014 – ongoing: Head of the Novartis PI3Kd-inhibitor trial on APDS in Europe
2008 - 2011: Steering Committee of the European Ig-Pro20 immunoglobulin trial
2007 - 2011: Member of the UK-PIN steering committee
2006 - 2010: Secretary of the European Society for Immunodeficiencies (ESID)
2002 - 2006: Head of the ESID Registry Working Party

Occasional reviewer for The New England Journal of Medicine, Nature, Journal of Experimental Medicine, Journal of Allergy and Clinical Immunology, and other Journals

Honors

Honors and Awards:

2012 Watson Memorial Lecture, University of Newcastle, UK
2010 Member of London Medical Research Club
2009 Thieme Research Prize of the Leopoldina, Halle
2009 Invitation to join the Henry Kunkel Society
2008 Richard S. Farr Memorial Lectureship at AAAAI
2007 Rudolph-Schoen Prize from the Medizinische Hochschule Hannover
2006 Marie-Curie Excellence Award of the European Commission for 4 years
2006 Election as Secretary for the European Society for Immunodeficiencies
2006 Georges Köhler Award 2006 of the German Immunology Society
2004 Award for the best project within the Freiburg Research Network SFB620
2002 Election to host the Clinical Patient Registry of ESID
2002 Admission to the Emmy Nöther program of the German research foundation
1999 Fellow of the Immunodeficiency Foundation (IDF)
1998 Poster award of NHGRI, NIH
1990 Fellowship of the Hans-Hench-foundation
1983 Fulbright-Fellow

 

Publications

Selected Publications:

Gámez-Díaz, L; August, D; Stepensky, P; Revel-Vilk, S; Seidel, MG; Noriko, M; Morio, T; Worth, A; Bleesing, J; Van De Veerdonk, F; Feuchtinger, T; Kanariou, MG; Schmitt-Gräff, A; Seneviratne, S; Burns, S; Belohradsky, B; Rezaei, N; Bakhtiar, S; Speckmann, C; Jordan, M; Grimbacher, B. The extended phenotype of LRBA deficiency. J Allergy Clin Immunol. 2016 Jan;137(1):223-30. Abstract

Engelhardt KR, Gertz ME, Keles S, Schäffer AA, Sigmund EC, Glocker C, Saghafi S, Pourpak Z, Ceja R, Sassi A, Graham LE, Massaad MJ, Mellouli F, Ben-Mustapha I, Khemiri M, Kilic SS, Etzioni A, Freeman AF, Thiel J, Schulze I, Al-Herz W, Metin A, Sanal Ö, Tezcan I, Yeganeh M, Niehues T, Dueckers G, Weinspach S, Patiroglu T, Unal E, Dasouki M, Yilmaz M, Genel F, Aytekin C, Kutukculer N, Somer A, Kilic M, Reisli I, Camcioglu Y, Gennery AR, Cant AJ, Jones A, Gaspar BH, Arkwright PD,  Pietrogrande MC, Baz Z, Al-Tamemi S, Lougaris V, Lefranc G, Megarbane A, Boutros J, Galal N, Bejaoui M, Barbouche MR, Geha RS, Chatila TA, Grimbacher B.
The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2015 Aug;136(2):402-12.
Abstract

Schubert D, Bode C, Kenefeck R, Hou TZ, Wing JB, Kennedy A, Bulashevska A, Petersen BS, Schäffer AA, Grüning BA, Unger S, Frede N, Baumann U, Witte T, Schmidt RE, Dueckers G, Niehues T, Seneviratne S, Kanariou M, Speckmann C, Ehl S, Rensing-Ehl A, Warnatz K, Rakhmanov M, Thimme R, Hasselblatt P, Emmerich F, Cathomen T, Backofen R, Fisch P, Seidl M, May A, Schmitt-Graeff A, Ikemizu S, Salzer U, Franke A, Sakaguchi S, Walker LS*, Sansom DM*, Grimbacher B*. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med. 2014 Dec;20(12):1410-6. Abstract

Sassi A, Lazaroski S, Wu G, Haslam SM, Fliegauf M, Mellouli F, Patiroglu T, Unal E, Ozdemir MA, Jouhadi Z, Khadir K, Ben-Khemis L, Ben-Ali M, Ben-Mustapha I, Borchani L, Pfeifer D, Jakob T, Khemiri M, Asplund AC, Gustafsson MO, Lundin KE, Falk-Sörqvist E, Moens LN, Gungor HE, Engelhardt KR, Dziadzio M, Stauss H, Fleckenstein B, Meier R, Prayitno K, Maul-Pavicic A, Schaffer S, Rakhmanov M, Henneke P, Kraus H, Eibel H, Kölsch U, Nadifi S, Nilsson M, Bejaoui M, Schäffer AA, Smith CI, Dell A, Barbouche MR, Grimbacher B. Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels. J Allergy Clin Immunol. 2014 May;133(5):1410-9, 1419.e1-13. Abstract

Lanternier F, Pathan S, Vincent QB, Liu L, Cypowyj S, Prando C, Migaud M, Taibi L, Ammar-Khodja A, Boudghene Stambouli O, Guellil B, Jacobs F, Goffard JC, Schepers K, del Marmol V, Boussofara L, Denguezli M, Larif M, Bachelez H, Michel L, Lefranc G, Hay R, Jouvion G, Chretien F, Fraitag S, Bougnoux ME, Boudia M, Abel L, Lortholary O, Casanova JL*, Picard C*, Grimbacher B*, Puel A.* Deep dermatophytosis and inherited CARD9 deficiency. N Engl J Med. 2013 Oct 31;369(18):1704-14. Abstract

Lopez-Herrera G, Tampella G, Pan-Hammarström Q, Herholz P, Trujillo-Vargas CM, Phadwal K, Simon AK, Moutschen M, Etzioni A, Mory A, Srugo I, Melamed D, Hultenby K, Liu C, Baronio M, Vitali M, Philippet P, Dideberg V, Aghamohammadi A, Rezaei N, Enright V, Du L, Salzer U, Eibel H, Pfeifer D, Veelken H, Stauss H, Lougaris V, Plebani A, Gertz EM, Schäffer AA, Hammarström L, Grimbacher B. Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity. Am J Hum Genet. 2012 Jun 8;90(6):986-1001. Abstract

Glocker EO, Frede N, Perro M, Sebire N, Elawad M, Shah N, Grimbacher B. Infant colitis--it's in the genes. Lancet. 2010 Oct 9;376(9748):1272. Abstract

Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schäffer AA, Noyan F, Perro M, Diestelhorst J, Allroth A, Murugan D, Hätscher N, Pfeifer D, Sykora KW, Sauer M, Kreipe H, Lacher M, Nustede R, Woellner C, Baumann U, Salzer U, Koletzko S, Shah N, Segal AW, Sauerbrey A, Buderus S, Snapper SB, Grimbacher B, Klein C. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
N Engl J Med. 2009 Nov 19;361(21):2033-45.
Abstract

Glocker EO, Hennigs A, Nabavi M, Schäffer AA, Woellner C, Salzer U, Pfeifer D, Veelken H, Warnatz K, Tahami F, Jamal S, Manguiat A, Rezaei N, Amirzargar AA, Plebani A, Hannesschläger N, Gross O, Ruland J, Grimbacher B. A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med. 2009 Oct 29;361(18):1727-35. Abstract

Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, Brodsky N, Freeman AF, Demidowich A, Davis J, Turner ML, Anderson VL, Darnell DN, Welch PA, Kuhns DB, Frucht DM, Malech HL, Gallin JI, Kobayashi SD, Whitney AR, Voyich JM, Musser JM, Woellner C, Schäffer AA, Puck JM, Grimbacher B. STAT3 mutations in the hyper-IgE syndrome. N Engl J Med. 2007 Oct 18;357(16):1608-19. Abstract

SGBM PhD students

SGBM PhD students:

ALUMNI:
Desirée Schubert (graduated 2017)

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