You are here: Home Our Members Principal Investigators
Anna Koettgen Profile Page
Anna Koettgen

Contact

Lab: Prof. Dr. Anna Köttgen
Department: Institute of Genetic Epidemiology
Department of Biometry, Epidemiology and Medical Bioinformatics
Address: Hugstetter Str. 49
79106 Freiburg
Phone: +49 761 270 78050
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.uniklinik-freiburg.de/genetic-epidemiology.html
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: - identification of genetic causes of chronic kidney disease, hyperuricemia and gout, and impaired electrolyte balance via genome-wide association studies and sequencing
- changes in metabolite profiles of kidney disease patients using metabolomics
- identification of risk factors for kidney disease progression and gout in large epidemiological cohort studies

CV

Education & Training: 2005-2006 M.P.H., Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
2002-2003 Certificate of Philosophical Ethics, University Hagen, Germany
2002 Doctoral Thesis (Prof. Dr. Greger, Department of Physiology, Albert-Ludwigs-University Freiburg, Germany. Dissertation: Mechanisms of the CFTR-mediated Inhibition of the Epithelial Sodium Channel (summa cum laude))
1994-2001 M.D., School of Medicine, Albert-Ludwigs-University Freiburg, Germany
2001 Full licensure to work as physician, German Medical Association
2003 USMLE II CK
2000 USMLE I
Employment & Experience: Since May 2017 - Director, Institute of Genetic Epidemiology
Since January 2016 - Professor of Genetic Epidemiology at the Faculty of Medicine, Freiburg
2013 - Offer, Chair of Epidemiology, Ludwig-Maximilians-University Munich, Germany
2010 - Group leader, Emmy Noether Research Group, Department of Nephrology, Freiburg University School of Medicine, Germany.
2009 – Study Site Director, German Chronic Kidney Disease Study, together with Prof. Dr. G. Walz (Dept. of Nephrology).
10/2009 - Assistant Professor - Adjunct, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
2009 Offer as Assistant Professor (tenure track), Departments of Epidemiology/Biostatistics and Medicine, Case Western Reserve
University, Cleveland, USA.
2008-09 Assistant Scientist, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
2006-08 Postdoctoral Research Fellow, The German Research Foundation, Department of Epidemiology, Welch Center for Prevention, Epidemiology & Clinical Research, Johns Hopkins University, Baltimore, USA.
Academic mentors: Josef Coresh, MD PhD, WH Linda Kao, PhD MHS
2005-06 Student Research, Department of Epidemiology, Johns Hopkins University.
2000-01 Medical Practical Year, Albert-Ludwigs-University Freiburg, Germany.
Scientific Activities: Professional activities
Society memberships:
2006- American Heart Association
2007- American Society of Nephrology
2008- American Society of Human Genetics
2010- German Society of Epidemiology


Editorial activities
Peer Review Activities:
Nature Genetics, New England Journal of Medicine, Journal of Clinical Investigation,
Annals of Internal Medicine, Journal of the American Society of Nephrology, Diabetes,
Archives of Internal Medicine, Circulation, American Journal of Kidney Diseases, Kidney
International, Science Translational Medicine, Atherosclerosis, Nature Reviews
Nephrology, Nephrology Dialysis Transplantation.

Honors

Honors and Awards:

2017 Franz-Volhard-Preis of the German Society of Nephrology
2011 Nils Alwall Preis of the German Society of Nephrology, together with PD Dr. C. Böger
2010 Travel award to the annual meeting of the European Renal Association (ERA-EDTA Congress), Munich, Germany. Abstract among the best abstracts submitted by young authors.
2010 Co-first author on 2009 PNAS paper: Cozzarelli Prize for outstanding scientific excellence and originality “Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout” by Owen M. Woodward, Anna Köttgen, Josef Coresh, Eric Boerwinkle, William B. Guggino, and Michael Köttgen
2009 Jeremiah and Rose Stamler Research Award for New Investigators, American Heart Association
1998-01 German National Academic Foundation Scholar (Studienstiftung des deutschen Volkes)
1999 Student delegate at the Annual Meeting of Nobel Prize Laureates, Lindau, Germany

Publications

Selected Publications:

Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, ..., Köttgen A, Kao WH, Fox CS. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016 Jan 21;7:10023. doi: 10.1038/ncomms10023. Abstract

Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, ..., Böger CA, Fox CS, Pattaro C, Köttgen A. Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes. Diabetes. 2015 Dec 2. pii: db151313. Abstract

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O’Seaghdha CM, Haller T, Yang Q, Tanaka T, Johnson AD, Kutalik Z, Smith AV, Shi J, Struchalin M, Middelberg RPS, Brown MJ, Gaffo AL, Pirastu N, Li G, Hayward C, Zemunik T, Huffman J, Yengo L, Zhao JH, Demirkan A, Feitosa MF, Liu X, Malerba G, Lopez LM, van der Harst P, Li X, Kleber ME, Hicks AA, Nolte IM, Johansson A, Murgia F, Wild SH, Bakker SJL, Peden JF, Dehghan A, Steri M, Tenesa A, Lagou V, Salo P, Mangino M, Rose LM, Lehtimäki T, Woodward OM, Okada Y, Tin A, Müller C, Oldmeadow C, Putku M, Czamara D, Kraft P, Frogheri L, Thun GA, Grotevendt A, Gislason GK, Harris TB, Launer LJ, McArdle P, Shuldiner AR, Boerwinkle E, Coresh J, Schmidt H, Schallert M, Martin NG, Montgomery GW, Kubo M, Nakamura Y, Tanaka T, Munroe PB, Samani NJ, Jacobs Jr DR, Liu K, D'Adamo P, Ulivi S, Rotter JI, Psaty BM, Vollenweider P, Waeber G, Campbell S, Devuyst O, Navaro P, Kolcic I, Hastie N, Balkau B, Froguel P, Esko T, Salumets A, Khaw KT, Langenberg C, Wareham NJ, Isaacs A, Kraja A, Zhang Q, Wild PS, Scott RJ, Holliday EG, Org E, Viigimaa M, Bandinelli S, Metter JE, Lupo A, Trabetti E, Sorice R, Döring A, Lattka E, Strauch K, Theis F, Waldenberger M, Wichmann HE, Davies G, Gow AJ, Bruinenberg M, LifeLines Cohort Study, Stolk RP, Kooner JS, Zhang W, Winkelmann BR, Boehm BO, Lucae S, Penninx BW, Smit JH, Curhan G, Mudgal P, Plenge RM, Portas L, Persico I, Kirin M, Wilson JF, Leach IM, van Gilst WH, Goel A, Ongen H, Hofman A, Rivadeneira F, Uitterlinden AG, Imboden M, von Eckardstein A, Cucca F, Nagaraja R, Piras MG, Nauck M, Schurmann C, Budde K, Ernst F, Farrington SM, Theodoratou E, Prokopenko I, Stumvoll M, Jula A, Perola M, Salomaa V, Shin SY, Spector TD, Sala C, Ridker PM, Kähönen M, Viikari J, Hengstenberg C, Nelson CP, the CARDIoGRAM Consortium, the DIAGRAM Consortium, the ICBP Consortium, the MAGIC Consortium, Meschia JF, Nalls MA, Sharma P, Singleton AB, Kamatani N, Zeller T, Burnier M, Attia J, Laan M, Klopp N, Hillege HL, Kloiber S, Choi H, Pirastu M, Tore S, Probst-Hensch NM, Völzke H, Gudnason V, Parsa A, Schmidt R, Whitfield JB, Fornage M, Gasparini P, Siscovick DS, Polasek O, Campbell H, Rudan I, Bouatia-Naji N, Metspalu A, Loos RJF, van Duijn CM, Borecki IB, Ferrucci L, Gambaro G, Deary IJ, Wolffenbuttel BHR, Chambers JC, März W, Pramstaller PP, Snieder H, Gyllensten U, Wright AF, Navis G, Watkins H, Witteman JCM, Sanna S, Schipf S, Dunlop MG, Tönjes A, Ripatti S, Soranzo N, Toniolo D, Chasman DI, Raitakari O, Kao WH, Ciullo M, Fox CS, Caulfield M, Bochud M, Gieger C. Multiple Novel Loci Highlighting Metabolic Control of Urate Production and Excretion are Associated with Gout. Nat Genet. 2012 Dec 23. doi: 10.1038/ng.2500. Abstract

Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa MF, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Lambert JC, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Coassin S, Pistis G; CARDIoGRAM Consortium; ICBP Consortium; the CARe Consortium; WTCCC2, Harris TB, Launer LJ; Thor Aspelund, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Stengel B, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki IB, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker PM, Parsa A, Bochud M, Heid IM, Kao WH, Fox CS, Köttgen A. Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet. 2012 Dec 15;21(24):5329-5343. Abstract

Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E; CARDIoGRAM, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmüller G, Köttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Römisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C. Human metabolic individuality in biomedical and pharmaceutical research. Nature. 2011 Aug 31;477(7362):54-60. Abstract

Stanescu HC, Arcos-Burgos M, Medlar A, Bockenhauer D, Kottgen A, Dragomirescu L, Voinescu C, Patel N, Pearce K, Hubank M, Stephens HA, Laundy V, Padmanabhan S, Zawadzka A, Hofstra JM, Coenen MJ, den Heijer M, Kiemeney LA, Bacq-Daian D, Stengel B, Powis SH, Brenchley P, Feehally J, Rees AJ, Debiec H, Wetzels JF, Ronco P, Mathieson PW, Kleta R. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med. 2011 Feb 17;364(7):616-26. Abstract

Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O’Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Paré G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer L, Harris TB, Rapmersaud E, Mitchell BD, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer I, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, Levy D, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Muenzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko ZS, Rivadeneira  F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SLR, Blankenberg S, Liu Z, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WHL, Heid IM, Fox CS. Multiple New Loci Associated with Kidney Function and Chronic Kidney Disease. Nat Genet 2010 May;42(5):376-84. Abstract

Woodward OM, Köttgen A, Coresh J, Boerwinkle E, Guggino WB, Köttgen M. Identification of a novel urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10338-42. Abstract

Köttgen A, Glazer NL, Dehghan A, Hwang SJ*, Katz R, Li M, Yang Q, Gudnason V, Launer LJ, Harris TB, Smith AV, Arking DE, Astor BC, Boerwinkle E, Ehret GB, Ruczinski I, Scharpf RB, Chen YI, de Boer IH, Haritunians T, Lumley T, Sarnak M, Siscovick D, Benjamin EJ, Levy D, Upadhyay A, Aulchenko YS, Hofman A, Rivadeneira F, Uitterlinden AG, van Duijn CM, Chasman DI, Paré G, Ridker PM, Kao WHL, Witteman JC, Coresh J, Shlipak MG, Fox CS. Multiple Novel Loci are Associated with Indices of Renal Function and Chronic Kidney Disease. Nat Genet. 2009 Jun;41(6):712-717. Abstract

Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WHL, Uitterlinden AG, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC*, Coresh J*, Fox CS*. Association of Three Genetic Loci with Uric Acid Levels and Gout Risk. Lancet. 2008 Dec 6;372(9654):1953-61. Abstract

Copyright © 2009-2020 University of Freiburg