Miriam Erlacher

Miriam Erlacher Profile Page

Contact

Lab:	PD Dr. Miriam Erlacher
Department:	Pediatrics and Adolescent Medicine University Medical Center
Address:	Div. of Pediatric Hematology and Oncology Mathildenstr. 1 79106 Freiburg
Phone:	0049 761 270 43010
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.research-for-children.de/groups/erlacher/
PhD positions available:	YES
Research Area:	Molecular Medicine
Research Interests:	Apoptosis signaling; haematopoietic stem cell biology; bone marrow failure; myelodysplastic syndromes; leukemia; stem cell transplantation; predisposition to myeloid maligneancies.

CV

Education & Training:	1997-2003 Study of Medicine, University of Innsbruck, Austria 2000-2002 MD thesis, Institute of Experimental Pathophysiology and Immunology, University of Innsbruck, Austria 2003-2006 PhD studies in the program „Molecular Oncology“ at the Innsbruck Medical University, Austria
Employment & Experience:	since 2019: Head of the NAMSE B “Center of Inborn and Acquired Blood Diseases” since 2018: Head of the coordinating study center of EWOG-MDS/SAA since 2017: Attending physician; Division of Pediatric Hematology and Oncology, Medical Center University of Freiburg 2015-2017: Pediatric hematologist and oncologist, Division of Ped. Hematology and Oncology, Medical Center University of Freiburg 2013-2015: Special training in pediatric hematology and oncology, Department of Pediatrics and Adolescent Medicine, Medical Center University of Freiburg 2006-2013: Medical training in pediatrics and adolescent medicine, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg since 2008: Physician scientist, junior group leader, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg 2006: Internship (Tirocinio), Hospital of Sterzing, Italy
Scientific Activities:	Support for young researchers: Executive Board member Spemann Graduate School of Biology and Medicine and Spokeswomen of the doctoral program „Moti-Vate“ for excellent medical students, Mentoring of Master, MD and PhD students (Faculty of Medicine -, Faculty of Molecular Medicine - and Faculty of Biology - University of Freiburg) Reviewer for: medical and biomedical journals (Nature Communications, Journal of Experimental Medicine, Blood, Blood advances, Haematologica, EMBO Journal, EMBO Molecular Medicine, Cell Death and Differentiation, Cell Death and Disease, Apoposis, PLOS One, Carcinogenesis), funding agencies (Schweizer Krebsliga, Deutsche José-Carreras-Leukämiestiftung, FWF, Österreichische Krebshilfe Tirol, L’OREAL Österreich Stipendium) and expert panels and universities (Albert-Ludwigs-Universität Freiburg: Auswahlverfahren SGBM und Moti-Vate Promotionsprogramme, Netzwerk-Anträge der Internationalen Graduiertenakademie Freiburg; European Hematology Association: Forschungsstipendien, GPOH: Kind-Philipp-Preis) Founding board member of the “Center for Junior Researchers – SciNet”, University of Freiburg, responsible for finances (since 2012)

Honors

Honors and Awards:

2021: Research award of the Förderverein für krebskranke Kinder e.V
2015-2020: ERC starting grant for the project “ApoptoMDS”, EU
2013-2014: Junior fellowship at FRIAS (Freiburg Institute for Advanced Studies), University of Freiburg
2013: Research prize of the Deutsche Arbeitsgemeinschaft für Knochenmark- und Blutstammzelltransplantation
2009-2013: Fellowship Margarete von Wrangell-Habilitationsprogramm, Ministerium für Wissenschaft, Forschung und Kunst in Baden-Württemberg and the European Social Fund
2010: Fellowship for the Translational Research Training in Hematology (TRTH), awarded by the European Hematology Association (EHA) and the American Society for Hematology (ASH)
2006: Thesis award of the Austrian Society of Allergology and Immunology
2006: Sanofi-Aventis-Award

Publications

Selected Publications:

Bohler S, Afreen S, Fernandez-Orth J, Demmerath EM, Molnar C, Wu Y, Weiss JM, Mittapalli VR, Konstantinidis L, Schmal H, Kunze M, Erlacher M. Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis. Haematologica. 2021 Dec 1;106(12):3136-3148. Abstract

Sahoo SS, Pastor VB, Goodings C, Voss RK, Kozyra EJ, Szvetnik A, Noellke P, Dworzak M, Starý J, Locatelli F, Masetti R, Schmugge M, De Moerloose B, Catala A, Kállay K, Turkiewicz D, Hasle H, Buechner J, Jahnukainen K, Ussowicz M, Polychronopoulou S, Smith OP, Fabri O, Barzilai S, de Haas V, Baumann I, Schwarz-Furlan S; European Working Group of MDS in Children (EWOG-MDS), Niewisch MR, Sauer MG, Burkhardt B, Lang P, Bader P, Beier R, Müller I, Albert MH, Meisel R, Schulz A, Cario G, Panda PK, Wehrle J, Hirabayashi S, Derecka M, Durruthy-Durruthy R, Göhring G, Yoshimi-Noellke A, Ku M, Lebrecht D, Erlacher M, Flotho C, Strahm B, Niemeyer CM, Wlodarski MW. Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes. Nat Med. 2021 Oct;27(10):1806-1817. Abstract

Kreutmair S, Erlacher M, Andrieux G, Istvanffy R, Mueller-Rudorf A, Zwick M, Rückert T, Pantic M, Poggio T, Shoumariyeh K, Mueller TA, Kawaguchi H, Follo M, Klingeberg C, Wlodarski M, Baumann I, Pfeifer D, Kulinski M, Rudelius M, Lemeer S, Kuster B, Dierks C, Peschel C, Cabezas-Wallscheid N, Duque-Afonso J, Zeiser R, Cleary ML, Schindler D, Schmitt-Graeff A, Boerries M, Niemeyer CM, Oostendorp RA, Duyster J, Illert AL. Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure. J Clin Invest. 2020 Jun 1;130(6):2827-2844. Abstract

Hamarsheh S, Osswald L, Saller BS, Unger S, De Feo D, Vinnakota JM, Konantz M, Uhl FM, Hamarsheh S, Osswald L, Saller BS, Unger S, De Feo D, Vinnakota JM, Konantz M, Uhl FM, Becker H, Lübbert M, Shoumariyeh K, Schürch C, Andrieux G, Venhoff N, Schmitt-Graeff A, Duquesne S, Pfeifer D, Cooper MA, Lengerke C, Boerries M, Duyster J, Niemeyer CM, Erlacher M, Blazar BR, Becher B, Groß O, Brummer T, Zeiser R. Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. Nat Commun. 2020 Apr 3;11(1):1659. Abstract

Afreen S, Bohler S, Müller A, Demmerath EM, Weiss JM, Jutzi JS, Schachtrup K, Kunze M, Erlacher M. BCL-XL expression is essential for human erythropoiesis and engraftment of hematopoietic stem cells. Cell Death Dis. 2020 Jan 6;11(1):8. Abstract

Krombholz CF, Gallego-Villar L, Sahoo SS, Panda PK, Wlodarski MW, Aumann K, Hartmann M, Lipka DB, Daskalakis M, Plass C, Niemeyer CM, Erlacher M, Flotho C. Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia. Leukemia. 2019 Jul;33(7):1805-1810. Abstract

Kollek M, Voigt G, Molnar C, Murad F, Bertele D, Krombholz CF, Bohler S, Labi V, Schiller S, Kunze M, Geley S, Niemeyer CM, Garcia-Saez A, Erlacher M. Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation. J Exp Med. 2017 Oct 2;214(10):2967-2983. Abstract

Krombholz CF, Aumann K, Kollek M, Bertele D, Fluhr S, Kunze M, Niemeyer CM, Flotho C, Erlacher M. Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice. Haematologica. 2016 May;101(5):597-606. Abstract

Labi V, Bertele D, Woess C, Tischner D, Bock FJ, Schwemmers S, Pahl HL, Geley S, Kunze M, Niemeyer CM, Villunger A, Erlacher M. Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf. EMBO Mol Med. 2013 Jan;5(1):122-36. Abstract

Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Starý J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet. 2010 Sep;42(9):794-800. Abstract

SGBM PhD students

SGBM PhD students:

Jovana Rajak (since November 2019)

Alumni:

Christian Molnár (March 2015-June 2020)