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Ulrich Hofmann


Lab: Prof. Dr. Ulrich Hofmann
Department: Department for General Neurosurgery
Endowed Peter-Osypka Professor for Neuroelectronic Systems
Address: University Hospital Freiburg
Neuroelectronic Systems
79108 Freiburg
Phone: +79 (0) 761 270 50076
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Neurosciences
Research Interests: Neuro-Engineering, Brain-Machine Interfacing, Multisite Neuronal Recordings, Therapeutic Microstimulations,
Bio-Signal Processing, Closed-Loop and Intelligent Implants, Neurosurgical Robotics


Education & Training: 10/1987 - 6/1993 Studies of Technical Physics, TU München, Dipl.-Phys. (Univ.)
1996 PhD - Dr. rer.nat., Technische Universität München
Employment & Experience: 7/1993 - 10/1995 Research Assistant at the Institute for Biophysics E22,Prof. Dr. E. Sackmann, TU München, München
10/1995 - 6/1996 Research Assistant at the Chair for Applied Physics, Prof. Dr. H.E. Gaub, Ludwig Maximilians-Universität, München
7/1996 - 12/1996 Post-Doc at the Institut för Fysikalisk Kemi, Prof. Dr. J. Rosenholm, Åbo Akademi, Turku, Finland
1/1997 - 11/1998 Post-Doc and Feodor-Lynen Fellow at the Division of Biology, Prof. Dr. J. Bower, California Institute of Technology, Pasadena, CA, USA
11/1998 - 04/2012 Tenured Senior Researcher at the Institute for Signal Processing, University of Lübeck, Lübeck.
Head of RG Biosignal Processing and Neural Engineering
1999 - 2001 Visiting Researcher, California Institute of Technology
2003 Habilitation in Computer Science, University of Lübeck
2008 (Apl.) Professor, University of Lübeck
since 05 / 2012 Peter Osypka Professor for Neuroelectronic Systems, Clinic for Neurosurgery, University Hospital Freiburg
Scientific Activities: Scientific Committees
EDERC (European DSP in Education and Research Conference) 2010, Nice; 2012, Amsterdam
BRAGFOST Symposium (Brasilian-German Frontiers in Science and Technology), Bento Goncalvez 2010; Potsdam 2011.
International Conference on Cognitive Neurodynamics ICCN 2011
BMT 2010, Session Chair „Neural Engineering“, Rostock 2010
INDOGFOE Symposium (Indo-German Frontiers in Engineering), Chennai 2009, (Session Chair: BioMEMS)
DKN 2009, München (Session Chair: New technologies in DBS)
IFESS 2008 in Freiburg, MBEC 2008 in Antwerp, EMBC 2008 in Vancouver
BMT 2005 (Session Chair: Monitoring)

Reviewer for Scientific Journals and Conferences:
IEEE Transactions on Biomedical Engineering, The Open Medical Informatics Journal, Neurocomputing, Physica A, J. Nanotechnology, J. Neural Engineering, Medical Engineering & Physics, ACM Transactions on Embedded Computing Systems, IEEE-EMBC, IEEE-NER

Reviewer for Grant Agencies:
European Commission, Brussels, ICT and FET 2009, FET 2012
U.S. – Israel Binational Science Foundation
Organisation for Scientific Research (NWO), Netherlands
Israel Science Foundation (ISF)
Agence National de la Recherche (ANR), France


Selected Publications:

Brain Stimulation and Foreign Body Reaction:

Joseph K, Kirsch M, Johnston M, Münkel C, Stieglitz T, Haas CA, Hofmann UG. Transcriptional characterization of the glial response due to chronic neural implantation of flexible microprobes. Biomaterials. 2021 Dec;279:121230. Abstract

Mottaghi S, Kohl S, Biemann D, Liebana S, Montaño Crespo RE, Buchholz O, Wilson M, Klaus C, Uchenik M, Münkel C, Schmidt R, Hofmann UG. Bilateral Intracranial Beta Activity During Forced and Spontaneous Movements in a 6-OHDA Hemi-PD Rat Model. Front Neurosci. 2021 Aug 12;15:700672.  Abstract

Dryg I, Xie Y, Bergmann M, Urban G, Shain W, Hofmann UG. Long-termin vivomonitoring of gliotic sheathing of ultrathin entropic coated brain microprobes with fiber-based optical coherence tomography. J Neural Eng. 2021 Mar 23;18(4). Abstract

Joseph, K., C. Vejmola, A. Hilse, P. Will, C. Münkel, O. Buchholz, J. Beck, V.M. Ravi, O. Schnell, D.H. Heiland, and U.G. Hofmann, Glial activation in the rodent cortex due to skull trepanation for probe implantation. J Neural Engineering, in review 2021.  

Microenvironment and GBM:

Maier JP, Ravi VM, Kueckelhaus J, Behringer SP, Garrelfs N, Will P, Sun N, von Ehr J, Goeldner JM, Pfeifer D, Follo M, Hannibal L, Walch AK, Hofmann UG, Beck J, Heiland DH, Schnell O, Joseph K. Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma. Cell Death Dis. 2021 Jul 21;12(8):723.  Abstract

Ravi, V.M., N. Neidert, P. Will, K. Joseph, J.P. Meier, J. Kückelhaus, L. Vollmer, J.M. Goeldner, S. Behringer, D. Pfeifer, F. Scherer, M. Boerries, M. Follo, T. Weiss, D. Delev, J. Kernbach, P. Franco, N. Schallner, M.S. Carro, U.G. Hofmann, C. Fung, R. Sankowski, M. Prinz, J. Beck, O. Schnell, and D.H. Heiland, T-Cell Dysfunction in the Glioblastoma Microenvironment is Mediated by Myeloid Cells Releasing Interleukin-10. accepted in Nature Communications, 2022.  

Nanoparticles and Magnetic Particle Imaging:

Herynek, V., Babič, M., Kaman, O. et al. Maghemite nanoparticles coated by methacrylamide-based polymer for magnetic particle imaging. J Nanopart Res 23, 52 (2021). Abstract

Bär, S., O. Buchholz, D.v. Elverfeldt, and U.G. Hofmann. Adaptive Micro-liter Fiducials for Pre-clinical MPI and MRI Imaging. in IEEE-EMBS submitted 2022. Glasgow: IEEE.   
Buchholz, O., S. Bär, K. Sajjamark, J. Chacon-Caldera, J. Franke, and U.G. Hofmann. MPI-based spatio-temporal estimation of a temperature profile induced by an IR laser. accepted in IWMPI 2022 - International Workshop on Magnetic Particle Imaging. 2022. Würzburg.   

Signal Processing:

Kahl L, Hofmann UG. Removal of ECG Artifacts Affects Respiratory Muscle Fatigue Detection-A Simulation Study. Sensors (Basel). 2021 Aug 23;21(16):5663.  Abstract

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