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Ulrich Hofmann


Lab: Prof. Dr. Ulrich Hofmann
Department: Department for General Neurosurgery
Endowed Peter-Osypka Professor for Neuroelectronic Systems
Address: University Hospital Freiburg
Neuroelectronic Systems
79108 Freiburg
Phone: +79 (0) 761 270 50076
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Neurosciences
Research Interests: Neuro-Engineering, Brain-Machine Interfacing, Multisite Neuronal Recordings, Therapeutic Microstimulations,
Bio-Signal Processing, Closed-Loop and Intelligent Implants, Neurosurgical Robotics


Education & Training: 10/1987 - 6/1993 Studies of Technical Physics, TU München, Dipl.-Phys. (Univ.)
1996 PhD - Dr. rer.nat., Technische Universität München
Employment & Experience: 7/1993 - 10/1995 Research Assistant at the Institute for Biophysics E22,Prof. Dr. E. Sackmann, TU München, München
10/1995 - 6/1996 Research Assistant at the Chair for Applied Physics, Prof. Dr. H.E. Gaub, Ludwig Maximilians-Universität, München
7/1996 - 12/1996 Post-Doc at the Institut för Fysikalisk Kemi, Prof. Dr. J. Rosenholm, Åbo Akademi, Turku, Finland
1/1997 - 11/1998 Post-Doc and Feodor-Lynen Fellow at the Division of Biology, Prof. Dr. J. Bower, California Institute of Technology, Pasadena, CA, USA
11/1998 - 04/2012 Tenured Senior Researcher at the Institute for Signal Processing, University of Lübeck, Lübeck.
Head of RG Biosignal Processing and Neural Engineering
1999 - 2001 Visiting Researcher, California Institute of Technology
2003 Habilitation in Computer Science, University of Lübeck
2008 (Apl.) Professor, University of Lübeck
since 05 / 2012 Peter Osypka Professor for Neuroelectronic Systems, Clinic for Neurosurgery, University Hospital Freiburg
Scientific Activities: Scientific Committees
EDERC (European DSP in Education and Research Conference) 2010, Nice; 2012, Amsterdam
BRAGFOST Symposium (Brasilian-German Frontiers in Science and Technology), Bento Goncalvez 2010; Potsdam 2011.
International Conference on Cognitive Neurodynamics ICCN 2011
BMT 2010, Session Chair „Neural Engineering“, Rostock 2010
INDOGFOE Symposium (Indo-German Frontiers in Engineering), Chennai 2009, (Session Chair: BioMEMS)
DKN 2009, München (Session Chair: New technologies in DBS)
IFESS 2008 in Freiburg, MBEC 2008 in Antwerp, EMBC 2008 in Vancouver
BMT 2005 (Session Chair: Monitoring)

Reviewer for Scientific Journals and Conferences:
IEEE Transactions on Biomedical Engineering, The Open Medical Informatics Journal, Neurocomputing, Physica A, J. Nanotechnology, J. Neural Engineering, Medical Engineering & Physics, ACM Transactions on Embedded Computing Systems, IEEE-EMBC, IEEE-NER

Reviewer for Grant Agencies:
European Commission, Brussels, ICT and FET 2009, FET 2012
U.S. – Israel Binational Science Foundation
Organisation for Scientific Research (NWO), Netherlands
Israel Science Foundation (ISF)
Agence National de la Recherche (ANR), France


Selected Publications:

Kirch, R.D., R. Pinnell, O. Christ, U.G. Hofmann, and J.C. Cassel, The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents. J Visualized Experiments, in press 2015.

Joseph, K., R. Varatharajan, S.C. Neto, U.G. Hofmann, V. Tronnier, and A. Moser, Modulation of extracellular levels of 5-HT in the caudate putamen of freely moving rats by high frequency stimulation of the subthalamic nucleus. The Open Neuroscience J, 2014, Vol. 8, pp 14-20. Abstract

Xie, Y., T. Heida, J. Stegenga, Y. Zhao, A. Moser, V. Tronnier, T.J. Feuerstein, and U.G. Hofmann, High frequency electrical stimulation suppresses cholinergic accumbens interneurons in acute rat brain slices through GABAB receptors. Europ. J. Neuroscience, 2014. Vol. 40, pp. 3653–3662. Abstract

Xie, Y., N. Martini, C. Hassler, R.D. Kirch, T. Stieglitz, A. Seifert, and U.G. Hofmann, In vivo monitoring of glial scar proliferation on chronically implanted neural electrodes by fiber optical coherence tomography. Frontiers in Neuroengineering, 2014. Abstract

Varatharajan, R., K. Joseph, S. Loeffler, H. Fuellgraf, U. G. Hofmann and A. Moser (2014). "N-Methyl-D-Aspartate Receptor Activation Interacts with electrical High Frequency Stimulation in the Rat Caudate Nucleus in vitro and in vivo." Open Journal of Neuroscience 4 (2). LINK

Richter, A., Xie, Y., Schumacher, A., Löffler, S., Kirch, R.D., Al-Hasani, J., Rapoport, D.H., Kruse, C., Moser, A., Tronnier, V., Danner, S., Hofmann, U.G., (2013) „Simple implantation method for flexible multisite electrodes to rat brains“. Frontiers in Neuroengineering, Vol 6, Art. 6, p1-6, doi:10.3389/fneng.2013.00006. LINK

Xie, Y., T. Bonin, S. Loeffler, G. Huettmann, V. Tronnier and U. G. Hofmann (2013). Coronal in vivo forward-imaging of rat brain morphology with an ultra-small optical coherence tomography fiber probe. Phys Med Biol 58(3): 555. Abstract

Richter, A., C. Kruse, A. Moser, U.G. Hofmann, and S. Danner. Cellular Modulation of Polymeric Device Surfaces: Promise of Adult Stem Cells for Neuro-Prosthetics. Frontiers in Neuroscience, 2011. 5: p. 10. LINK

Hiller, A., S. Loeffler, C. Haupt, M. Litza, T. Gritsun, U.G. Hofmann, and A. Moser, (2007) „Electrical High Frequency Stimulation Induces GABA Outflow in Freely Moving Rats.“ J. Neurosci. Meth. 159(2): p. 286-290. Abstract

Hofmann, U. G., A. Folkers, F. Mösch, T. Malina, K. Menne, M. G. Kindlundh, P. Norlin, U. Thomas, D. Hoehl, M. d. Curtis, G. Biella, E. D. Schutter, P. Fagerstedt, K. Yoshida and W. Jensen. (2006)"A novel high channel-count system for acute multi-site neuronal recordings." IEEE Trans. Biomed. Eng., 53 (8), 1672 ff. Abstract

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