Hartmut Hengel

Hartmut Hengel Profile Page

Contact

Department:	Department of Virology Institute of Medical Microbiology and Hygiene
Address:	Hermann-Herder-Straße 11 79104 Freiburg
Phone:	49 (761) 203 6534
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.uniklinik-freiburg.de/virologie-en/research/research-teams/hartmut-hengel-team.html
PhD positions available:	YES
Research Area:	Immunology and Virology
Research Interests:	- Identification and elucidation of the function of cytomegalovirus (CMV)-encoded Fc- receptors; CMV FcgammaR as mediators of immune evasion - Effector functions of antiviral IgG antibodies - Host defense by host FcgammaRs - Natural killer cells in antiviral defense

CV

Education & Training:	1981 -1987 Medical studies, University of Ulm 1987 Medical license 1989 MD, University of Ulm (Prof. Dr. Hermann Wagner, Institute of Microbiology, Department of Immunology)
Employment & Experience:	1990 - 1993 University of Ulm, Institute of Microbiology, Department of Virology (Prof. Dr. Ulrich H. Koszinowski) 1993 Guest Scientist, University of Leiden, The Netherlands, Department of Immunohematology and Blood Bank (Dr. E. Goulmy) 1993 - 1996 Scientist, Hygiene-Institute of Ruprecht-Karls University Heidelberg, Department of Virology (Prof. Dr. Ulrich H. Koszinowski) 1994 - 1995 training in pediatrics, university pediatric clinic Heidelberg (Prof. Dr. Hans Joachim Bremer) 1995 - 1996 training in Hospital and Environment Hygiene, Departmment of Hygiene and Med. Microbiology, Hygiene Institute of Heidelberg University (Prof. Dr. H.-G. Sonntag) 1996 - 1999 group leader at the Gene Center of Ludwig-Maximilians University Munich and at the Virology chair of Max von Pettenkofer Institute of LMU Munich (Prof. Dr. Ulrich H. Koszinowski) 1998 Habilitation in Virology, Venia legendi 2000 - 2004 Leader in the field of “Viral Infections” atRobert Koch Institute (RKI) Berlin 2001 Teaching license in the field of Virology, Freie Universität Berlin 2001 Acting director in the Department Infectious Diseases, RKI Berlin 2002 Chairperson of the council „Immunobiology of Viral Diseases“ of the "Gesellschaft für Virologie" (GfV) 2002 Director and Professor at Robert Koch Institute 2004 - 2012 Full professor and Director of the Institute of Virology, Heinrich-Heine University Düsseldorf since 11/2012 Full professor and Director of the Institute of Virology, Albert-Ludwigs University Freiburg
Scientific Activities:	2005 - 2009 Member of the Scientific Advisory Board (SAB) on Measles and Varicella (AGMV) 2007 - Editor, Virus Genes (Springer-Verlag) 2007 - 2011 Editorial board "Bundesgesundheitsblatt" 2007 - Member of the standing Committee on Vaccination (STIKO) 2007 - SAB member of the Center of Infection Biology and Immunity (ZIBI) at Humboldt-University Berlin 2008 - 2011 Advisor for the German Society of Virology (GfV) 2008 - SAB member of IZKF at University Erlangen – Nürnberg 2009 - 2012 Vice dean of the Medical Faculty, Heinrich-Heine University Düsseldorf 2011 - Second vice president of the German Society of Virology (GfV) 2012 - Member of the "Fachkollegium" 204 (Virology, Microbiology, Immunology) of Deutsche Forschungsgemeinschaft (DFG) Co-chairman of the DFG "Fachkollegium" 204 SAB member of Paul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines 2014 - First vice president of the German Society of Virology (GfV) 2016 – 2019 Coordinator, InfectERA Research network TANKACY (Targeting Natural Killer Cells Against Cytomegalovirus) Since 2017 Deputy Chairperson, SAB of Paul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines 2017 – 2020 President, Society of Virology (GfV) Since 2017 SAB of the Federal Ministry of Health, guest member Since 2020 Local Coordinator, National Network of University Medicine SARS-CoV-2

Publications

Selected Publications:

Chen H, Maul-Pavicic A, Holzer M, Huber M, Salzer U, Chevalier N, Voll RE, Hengel H, Kolb P. Detection and functional resolution of soluble immune complexes by an FcγR reporter cell panel. EMBO Mol Med. 2022 Jan 11;14(1):e14182. Abstract

Baasch S, Giansanti P, Kolter J, Riedl A, Forde AJ, Runge S, Zenke S, Elling R, Halenius A, Brabletz S, Hengel H, Kuster B, Brabletz T, Cicin-Sain L, Arens R, Vlachos A, Rohr JC, Stemmler MP, Kopf M, Ruzsics Z, Henneke P. Cytomegalovirus subverts macrophage identity. Cell. 2021 Jul 8;184(14):3774-3793.e25. Abstract

Kolb P, Hoffmann K, Sievert A, Reinhard H, Merce-Maldonado E, Le-Trilling VTK, Halenius A, Gütle D, Hengel H. Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation. Elife. 2021 Mar 16;10:e63877. Abstract

Angulo G, Zeleznjak J, Martínez-Vicente P, Puñet-Ortiz J, Hengel H, Messerle M, Oxenius A, Jonjic S, Krmpotić A, Engel P, Angulo A. Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. Elife. 2021 Jan 18;10:e59350. Abstract

Le-Trilling VTK, Becker T, Nachshon A, Stern-Ginossar N, Schöler L, Voigt S, Hengel H, Trilling M. The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity. Cell Rep. 2020 Feb 18;30(7):2248-2260.e5. Abstract

Rölle A, Pollmann J, Ewen EM, Le VT, Halenius A, Hengel H, Cerwenka A. IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion. J Clin Invest. 2014 Dec;124(12):5305-16. Abstract

Corrales-Aguilar E, Trilling M, Hunold K, Fiedler M, Le VT, Reinhard H, Ehrhardt K, Mercé-Maldonado E, Aliyev E, Zimmermann A, Johnson DC, Hengel H. Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III. PLoS Pathog. 2014 May 15;10(5):e1004131. Abstract

Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, Qian SB, Hengel H, Mann M, Ingolia NT, Weissman JS. Decoding human cytomegalovirus. Science. 2012 Nov 23;338(6110):1088-93. Abstract

Atalay R, Zimmermann A, Wagner M, Borst E, Benz C, Messerle M, Hengel H. Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcgamma receptor homologs. J Virol. 2002 Sep;76(17):8596-608. Abstract

Hengel H, Koopmann JO, Flohr T, Muranyi W, Goulmy E, Hämmerling GJ, Koszinowski UH, Momburg F. A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter. Immunity. 1997 May;6(5):623-32. Abstract

SGBM PhD students

SGBM PhD students:

Carolin Gerke (since April 2016)

Alumni:

Precious Cramer (01/2017-09/2021)