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Contact
| Department: | Department of Virology Institute of Medical Microbiology and Hygiene |
| Address: | Hermann-Herder-Straße 11 79104 Freiburg |
| Phone: | 49 (761) 203 6534 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | www.uniklinik-freiburg.de/virologie-en/research/research-teams/hartmut-hengel-team.html |
| PhD positions available: | YES |
| Research Area: | Immunology and Virology |
| Research Interests: | - Identification and elucidation of the function of cytomegalovirus (CMV)-encoded Fc- receptors; CMV FcgammaR as mediators of immune evasion - Effector functions of antiviral IgG antibodies - Host defense by host FcgammaRs - Natural killer cells in antiviral defense |
CV
| Education & Training: | 1981 -1987 Medical studies, University of Ulm 1987 Medical license 1989 MD, University of Ulm (Prof. Dr. Hermann Wagner, Institute of Microbiology, Department of Immunology) |
| Employment & Experience: | 1990 - 1993 University of Ulm, Institute of Microbiology, Department of Virology (Prof. Dr. Ulrich H. Koszinowski) 1993 Guest Scientist, University of Leiden, The Netherlands, Department of Immunohematology and Blood Bank (Dr. E. Goulmy) 1993 - 1996 Scientist, Hygiene-Institute of Ruprecht-Karls University Heidelberg, Department of Virology (Prof. Dr. Ulrich H. Koszinowski) 1994 - 1995 training in pediatrics, university pediatric clinic Heidelberg (Prof. Dr. Hans Joachim Bremer) 1995 - 1996 training in Hospital and Environment Hygiene, Departmment of Hygiene and Med. Microbiology, Hygiene Institute of Heidelberg University (Prof. Dr. H.-G. Sonntag) 1996 - 1999 group leader at the Gene Center of Ludwig-Maximilians University Munich and at the Virology chair of Max von Pettenkofer Institute of LMU Munich (Prof. Dr. Ulrich H. Koszinowski) 1998 Habilitation in Virology, Venia legendi 2000 - 2004 Leader in the field of “Viral Infections” atRobert Koch Institute (RKI) Berlin 2001 Teaching license in the field of Virology, Freie Universität Berlin 2001 Acting director in the Department Infectious Diseases, RKI Berlin 2002 Chairperson of the council „Immunobiology of Viral Diseases“ of the "Gesellschaft für Virologie" (GfV) 2002 Director and Professor at Robert Koch Institute 2004 - 2012 Full professor and Director of the Institute of Virology, Heinrich-Heine University Düsseldorf since 11/2012 Full professor and Director of the Institute of Virology, Albert-Ludwigs University Freiburg |
| Scientific Activities: | 2005 - 2009 Member of the Scientific Advisory Board (SAB) on Measles and Varicella (AGMV) 2007 - Editor, Virus Genes (Springer-Verlag) 2007 - 2011 Editorial board "Bundesgesundheitsblatt" 2007 - Member of the standing Committee on Vaccination (STIKO) 2007 - SAB member of the Center of Infection Biology and Immunity (ZIBI) at Humboldt-University Berlin 2008 - 2011 Advisor for the German Society of Virology (GfV) 2008 - SAB member of IZKF at University Erlangen – Nürnberg 2009 - 2012 Vice dean of the Medical Faculty, Heinrich-Heine University Düsseldorf 2011 - Second vice president of the German Society of Virology (GfV) 2012 - Member of the "Fachkollegium" 204 (Virology, Microbiology, Immunology) of Deutsche Forschungsgemeinschaft (DFG) Co-chairman of the DFG "Fachkollegium" 204 SAB member of Paul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines 2014 - First vice president of the German Society of Virology (GfV) |
Publications
| Selected Publications: | Rölle, A., Pollmann, J., Ewen, E-M., Halenius, A., Hengel, H., and Cerwenka, A. 2014. CD14+cells, IL-12 and HLA-E drive NKG2C+NK cell expansion in HCMV infection. Journal of Clinical Investigation, 124: 5305 - 16. Abstract Corrales-Aguilar, E., Trilling, M., Hunold, K., Fiedler, M., Le, V.T.K., Reinhard, H., Ehrhardt, K., Mercé-Maldonado E., Alijev, E., Zimmermann, A., Johnson, D.C. and Hengel, H. 2014. Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III. PLoS Pathogens, May 15;10(5): e1004131. Abstract Corrales-Aguilar, E., Hoffmann, K., Hengel, H. 2014. CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity. Seminars in Immunopathology, 36: 627 - 40. Abstract Corrales-Aguilar, E., Trilling, M., Reinhard, H., Mercé_Maldonado E., Widera, M., Schaal, H., Zimmermann, A., Mandelboim, O. and Hengel, H. 2013. A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors. Journal of Immunological Methods, 387: 21 - 35. Abstract Stern-Ginossar, N., Weisburd, B., Michalski, A., Le, V.T.K., Hein, M.Y, Huang, S.X., Ma, M., Shen, B., Qian, S.B., Hengel, H., Mann, M., Ingolia, N.T., and Weissman, J.S. 2012. Decoding human cytomegalovirus. Science, 338: 1088 - 1093. Abstract Le, V.T.K., Trilling H. and Hengel, H. 2011. The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling. Journal of Virology, 85: 13260 – 13270. Abstract Halenius, A., Hauka, S., Dölken, L., Stindt, J., Reinhardt, H., Wiek, C., Hanenberg, H., Koszinowski, U.H., Momburg, F., and Hengel, H. 2011. Human cytomegalovirus disrupts the MHC class I peptide loading complex (PLC) and inhibits tapasin gene transcription. Journal of Virology, 85:3473 - 3485. Abstract Trilling, M., Le, V.T.K., Fiedler, M., Bleifuß, E., Zimmermann, A., and Hengel, H. 2011. Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells. PLoS Pathogens, Jun;7(6):e1002069. Abstract Stern-Ginossar, N., Elefant, N., Zimmermann, A., Wolf, D.G., Saleh, N., Biton, M., Horwitz, E., Prokocimer, Z., Prichard, M., Goldman-Wohl, D., Greenfield, C., Yagel, S., Hengel, H., Altuvia, Y., Margalit, H., Mandelboim, O. 2007. Host immune system gene targeting by a viral miRNA. Science, 317:376-381. Abstract Lenac, T., Budt, M., Arapovic, J., Hasan, M., Zimmermann, A., Simic, H., Krmpotic, A., Messerle, M., Ruzsics, Z., Koszinowski, U.H., Hengel, H.*, and Jonjic, S*. 2006. The herpesviral Fc receptor fcr-1 as a potent down-regulator of the NKG2D ligands MULT-1 and H60. Journal of Experimental Medicine, 203:1843-2850. Abstract *Corresponding authors |
SGBM PhD students
| SGBM PhD students: | Track 1: Precious Cramer (since January 2017) Track 2: Carolin Gerke (since April 2016) |
