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Hartmut Hengel Profile Page
Hartmut Hengel


Department: Department of Virology
Institute of Medical Microbiology and Hygiene
Address: Hermann-Herder-Straße 11
79104 Freiburg
Phone: 49 (761) 203 6534
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: - Identification and elucidation of the function of cytomegalovirus (CMV)-encoded Fc- receptors; CMV FcgammaR as mediators of immune evasion
- Effector functions of antiviral IgG antibodies
- Host defense by host FcgammaRs
- Natural killer cells in antiviral defense


Education & Training: 1981 -1987 Medical studies, University of Ulm
1987 Medical license
1989 MD, University of Ulm (Prof. Dr. Hermann Wagner, Institute of Microbiology, Department of Immunology)
Employment & Experience: 1990 - 1993 University of Ulm, Institute of Microbiology, Department of Virology (Prof. Dr. Ulrich H. Koszinowski)
1993 Guest Scientist, University of Leiden, The Netherlands, Department of Immunohematology and Blood Bank (Dr. E. Goulmy)
1993 - 1996 Scientist, Hygiene-Institute of Ruprecht-Karls University Heidelberg, Department of Virology (Prof. Dr. Ulrich H. Koszinowski)
1994 - 1995 training in pediatrics, university pediatric clinic Heidelberg (Prof. Dr. Hans Joachim Bremer)
1995 - 1996 training in Hospital and Environment Hygiene, Departmment of Hygiene and Med. Microbiology, Hygiene Institute of Heidelberg University (Prof. Dr. H.-G. Sonntag)
1996 - 1999 group leader at the Gene Center of Ludwig-Maximilians University Munich and at the Virology chair of Max von Pettenkofer Institute of LMU Munich (Prof. Dr. Ulrich H. Koszinowski)
1998 Habilitation in Virology, Venia legendi
2000 - 2004 Leader in the field of “Viral Infections” atRobert Koch Institute (RKI) Berlin
2001 Teaching license in the field of Virology, Freie Universität Berlin
2001 Acting director in the Department Infectious Diseases, RKI Berlin
2002 Chairperson of the council „Immunobiology of Viral Diseases“ of the "Gesellschaft für Virologie" (GfV)
2002 Director and Professor at Robert Koch Institute
2004 - 2012 Full professor and Director of the Institute of Virology, Heinrich-Heine University Düsseldorf
since 11/2012 Full professor and Director of the Institute of Virology, Albert-Ludwigs University Freiburg
Scientific Activities: 2005 - 2009 Member of the Scientific Advisory Board (SAB) on Measles and Varicella (AGMV)
2007 - Editor, Virus Genes (Springer-Verlag)
2007 - 2011 Editorial board "Bundesgesundheitsblatt"
2007 - Member of the standing Committee on Vaccination (STIKO)
2007 - SAB member of the Center of Infection Biology and Immunity (ZIBI) at Humboldt-University Berlin
2008 - 2011 Advisor for the German Society of Virology (GfV)
2008 - SAB member of IZKF at University Erlangen – Nürnberg
2009 - 2012 Vice dean of the Medical Faculty, Heinrich-Heine University Düsseldorf
2011 - Second vice president of the German Society of Virology (GfV)
2012 - Member of the "Fachkollegium" 204 (Virology, Microbiology, Immunology) of Deutsche Forschungsgemeinschaft (DFG)
Co-chairman of the DFG "Fachkollegium" 204
SAB member of Paul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines
2014 - First vice president of the German Society of Virology (GfV)


Selected Publications:

Rölle, A., Pollmann, J., Ewen, E-M., Halenius, A., Hengel, H., and Cerwenka, A. 2014. CD14+cells, IL-12 and HLA-E drive NKG2C+NK cell expansion in HCMV infection. Journal of Clinical Investigation, 124: 5305 - 16. Abstract

Corrales-Aguilar, E., Trilling, M., Hunold, K., Fiedler, M., Le, V.T.K., Reinhard, H., Ehrhardt, K., Mercé-Maldonado E., Alijev, E., Zimmermann, A., Johnson, D.C. and Hengel, H. 2014. Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III. PLoS Pathogens, May 15;10(5): e1004131. Abstract

Corrales-Aguilar, E., Hoffmann, K., Hengel, H. 2014. CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity. Seminars in Immunopathology, 36: 627 - 40. Abstract

Corrales-Aguilar, E., Trilling, M., Reinhard, H., Mercé_Maldonado E., Widera, M., Schaal, H., Zimmermann, A., Mandelboim, O. and Hengel, H. 2013. A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors. Journal of Immunological Methods, 387: 21 - 35. Abstract

Stern-Ginossar, N., Weisburd, B., Michalski, A., Le, V.T.K., Hein, M.Y, Huang, S.X., Ma, M., Shen, B., Qian, S.B., Hengel, H., Mann, M., Ingolia, N.T., and Weissman, J.S. 2012. Decoding human cytomegalovirus. Science, 338: 1088 - 1093. Abstract

Le, V.T.K., Trilling H. and Hengel, H. 2011. The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling. Journal of Virology, 85: 13260 – 13270. Abstract

Halenius, A., Hauka, S., Dölken, L., Stindt, J., Reinhardt, H., Wiek, C., Hanenberg, H., Koszinowski, U.H., Momburg, F., and Hengel, H. 2011. Human cytomegalovirus disrupts the MHC class I peptide loading complex (PLC) and inhibits tapasin gene transcription. Journal of Virology, 85:3473 - 3485. Abstract

Trilling, M., Le, V.T.K., Fiedler, M., Bleifuß, E., Zimmermann, A., and Hengel, H. 2011. Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells. PLoS Pathogens, Jun;7(6):e1002069. Abstract

Stern-Ginossar, N., Elefant, N., Zimmermann, A., Wolf, D.G., Saleh, N., Biton, M., Horwitz, E., Prokocimer, Z., Prichard, M., Goldman-Wohl, D., Greenfield, C., Yagel, S., Hengel, H., Altuvia, Y., Margalit, H., Mandelboim, O. 2007. Host immune system gene targeting by a viral miRNA. Science, 317:376-381. Abstract

Lenac, T., Budt, M., Arapovic, J., Hasan, M., Zimmermann, A., Simic, H., Krmpotic, A., Messerle, M., Ruzsics, Z., Koszinowski, U.H., Hengel, H.*, and Jonjic, S*. 2006. The herpesviral Fc receptor fcr-1 as a potent down-regulator of the NKG2D ligands MULT-1 and H60. Journal of Experimental Medicine, 203:1843-2850. Abstract

*Corresponding authors

SGBM PhD students

SGBM PhD students:

Track 1:

Precious Cramer (since January 2017)

Track 2:

Carolin Gerke (since April 2016)

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