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Georg Kochs

Contact

Lab: PD Dr. Georg Kochs
Department: Department of Medical
Microbiology and Hygiene
Address: Institute of Virology
Hermann-Herder-Str. 11
79104 Freiburg
Phone: 0049 761 203 6623
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.uniklinik-freiburg.de/virologie-en/research/research-teams/georg-kochs-team.html
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: - Molecular biology of Orthomyxoviruses (influenza A virus and tick-transmitted Thogoto virus).
- Interferon-inducing capacity of RNA viruses, like Influenza- and Bunyaviruses.
- Role of the viral NS1 protein for influenza virus pathogenesis in the mouse model.
- The antiviral function of the human and murine Mx proteins.
- Viral escape from the antiviral action of interferons and Mx proteins.
- Evolution of Mx proteins in primates, rodents and bats.

CV

Education & Training: 1985-1988 PhD thesis at the Institute of Biochemistry, Faculty of Biology, University of Freiburg
Employment & Experience: since 2003 apl. Professor, University of Freiburg
since 1998 Research group leader, Dept. of Virology, Freiburg
1998 Habilitation with venia legendi (teaching permit) in Virology
1993-1998 Postdoctoral fellow, Dept. of Virology, University of Freiburg
1989-1992 Group leader in research & development, Goedecke AG, FR

Publications

Selected Publications:

Dick, A., Graf, L., Olal, D., vd. Malsburg, A., Gao, S., Kochs, G., and Daumke, O. Role of Nucleotide Binding and GTPase domain dimerization in dynomin-like myxovirus resistance protein A for GTPase activation and antiviral activity. J. Biol. Chem. jbc.M115.650325 (2015) Abstract

Haller, O., Staeheli, P., Schwemmle, M., and Kochs, G. Mx GTPases: dynamin-like antiviral machines of innate immunity. Trends in Microbiology 23, 154-163 (2015)Abstract

Riegger, D., Hai, R., Dornfeld, D., Mänz, B., Leyva-Grado, V., Sánchez-Aparicio, M., Albrecht, R., Palese, P., Haller, O., Schwemmle, M., García-Sastre, A., Kochs, G., and Schmolke, M. The nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA. J. Virol. 89, 2241- 52 (2015) Abstract

Patzina, C., Haller, O., and Kochs, G. Structural requirements for the antiviral activity of the human MxA protein against Thogoto and Influenza A virus. J. Biol. Chem. 289, 6020-7. (2014) Abstract

Lohrmann, F., Dijkman, R., Stertz, S., Thiel, V., Haller, O., Staeheli, P., and Kochs, G. Emergence of a C-terminal seven amino acid elongation of NS1 around 1950 conferred a minor growth advantage to former seasonal influenza A viruses. J. Virol., 87, 11300-303. (2013) Abstract

Mänz, B., Dornfeld, D., Götz, V., Zell, R., Zimmermann, P., Haller, O., Kochs, G. and Schwemmle, M. Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein. Plos Pathogen 9, e1003279. (2013) Abstract

Mitchell, P.S., Patzina, C., Emerman, M., Haller, O., Malik, H.S., Kochs, G. Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA. Cell Host & Microbe 12, 598-604. (2012) Abstract

Gao, S., vd. Malsburg, A., Dick, A., Faelber, K., Schroeder, G.F., Haller, O., Kochs, G., and Daumke, O. Structure of Myxovirus resistance protein A (MxA) reveals intra- and intermolecular domain interactions required for the antiviral function. Immunity 35, 514-525. (2011) Abstract

Kochs, G., Bauer, S., Vogt, C., Frenz, T., Tschopp, J., Kalinke, U., and Waibler, Z. Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells. J. Virol. 84, 12344-12350. (2010) Abstract

Gao, S., vd Malsburg, A., Paeschke, S., Behlke, J., Haller, O., Kochs, G., Daumke, O. Structural basis of oligomerisation in the stalk region of dynamin-like MxA. Nature, 465, 502-506. (2010) Abstract

SGBM PhD students

SGBM PhD students:

 

ALUMNI:

Track 2:
Laura Graf (March 2014-June 2018)

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