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Contact
| Lab: | Prof. Dr. Philipp Henneke |
| Department: | Center for Chronic Immunodeficiency – CCI Center of Pediatrics and Adolescent Medicine |
| Address: | Breisacher Straße 117 79106 Freiburg |
| Phone: | +49 761 270-77542 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | www.research-for-children.de/groups/henneke/ |
| PhD positions available: | YES |
| Research Area: | Immunology and Virology |
| Research Interests: | 1. Development of cellular innate immunity against commensals of the skin (staphylococci) and respiratory/ intestinal tract (streptococci) at the beginning of life in humans and mice. 2. Receptor-based recognition of bacterial effectors, in particular lipopetides and cytolysins, by macrophages and neutrophils. The particular focus lies on Toll-like receptor signaling and the inflammasome. 3. Cell-fate decisions in monocytes/ macrophages, and the impact of these processes on site specific immunity against bacteria (streptococci, staphylococci, mycobacteria). |
CV
| Education & Training: | 1987 – 1994 Medical School, FU Berlin and Imperial College, London 1994 – 1999 Physician, Center for Pediatrics, FU Berlin 1995 MD, Berlin |
| Employment & Experience: | 2001 – 2002 Instructor/ Assistant Professor, Univ. of Massachusetts, Worcester (USA) 2001 – 2002 Lecturer, Harvard Medical School (Boston) 2003 – 2009 Assistant Professor (W1), Albert-Ludwigs-Universität Freiburg 2005 Habilitation, Pediatrics, Albert-Ludwigs-Universität Freiburg 2005 – 2012 Consultant, Center for Pediatrics and Adolescent Medicine, Freiburg 2008 – 2012 Consultant, Center for Chronic Immunodeficiency (CCI), Freiburg 2009 Call on „W3- Professorship of Infectious Diseases and Immunology“ University of Tübingen (declined) since 2012 W3- Professor of Infection and Immunity, Albert-Ludwigs-Universität Freiburg Head of Pediatric Infectious Diseases and Rheumatology, Center for Pediatrics and Adolescent Medicine, Freiburg and Center for Chronic Immunodeficiency – CCI, Freiburg |
Publications
| Selected Publications: | Schwab, L., L. Goroncy, S. Palaniyandi, S. Gautam, A. Triantafyllopoulou, A. Mocsai, W. Reichardt, F. J. Karlsson, S. V. Radhakrishnan, K. Hanke, A. Schmitt-Graeff, M. Freudenberg, F. D. von Loewenich, P. Wolf, F. Leonhardt, N. Baxan, D. Pfeifer, O. Schmah, A. Schonle, S. F. Martin, R. Mertelsmann, J. Duyster, J. Finke, M. Prinz, P. Henneke, H. Hacker, G. C. Hildebrandt, G. Hacker, and R. Zeiser. 2014. Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage. Nat Med 20:648-654. Abstract Landwehr-Kenzel, S., and P. Henneke. 2014. Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease. Front Immunol 5:519. Abstract Gupta, R., S. Ghosh, B. Monks, R. B. DeOliveira, T. C. Tzeng, P. Kalantari, A. Nandy, B. Bhattacharjee, J. Chan, F. Ferreira, V. Rathinam, S. Sharma, E. Lien, N. Silverman, K. Fitzgerald, A. Firon, P. Trieu-Cuot, P. Henneke, and D. T. Golenbock. 2014. RNA and beta-hemolysin of group B Streptococcus induce interleukin-1beta (IL-1beta) by activating NLRP3 inflammasomes in mouse macrophages. J Biol Chem 289:13701-13705. Abstract Pannicke, U.*, B. Baumann*, S. Fuchs*, P. Henneke*, A. Rensing-Ehl, M. Rizzi, A. Janda, K. Hese, M. Schlesier, K. Holzmann, S. Borte, C. Laux, E. M. Rump, A. Rosenberg, T. Zelinski, H. Schrezenmeier, T. Wirth, S. Ehl, M. L. Schroeder, and K. Schwarz. 2013. Deficiency of innate and acquired immunity caused by an IKBKB mutation. N Engl J Med 369:2504-2514. * Equal contribution Abstract Fliegauf, M., A. F. Sonnen, B. Kremer, and P. Henneke. 2013. Mucociliary clearance defects in a murine in vitro model of pneumococcal airway infection. PLoS One 8:e59925. Abstract Kenzel, S., M. Mergen, J. von Susskind-Schwendi, J. Wennekamp, S. D. Deshmukh, M. Haeffner, A. Triantafyllopoulou, S. Fuchs, S. Farmand, S. Santos-Sierra, J. Seufert, T. K. van den Berg, T. W. Kuijpers, and P. Henneke. 2012. Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase. J Immunol 189:4582-4591. Abstract Deshmukh, S. D., S. Muller, K. Hese, K. S. Rauch, J. Wennekamp, O. Takeuchi, S. Akira, D. T. Golenbock, and P. Henneke. 2012. NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA. J Immunol 188:774-780. Abstract Deshmukh, S. D., B. Kremer, M. Freudenberg, S. Bauer, D. T. Golenbock, and P. Henneke. 2011. Macrophages recognize streptococci through bacterial single-stranded RNA. EMBO Rep 12:71-76. Abstract Santos-Sierra, S., S. D. Deshmukh, J. Kalnitski, P. Kuenzi, M. P. Wymann, D. T. Golenbock, and P. Henneke. 2009. Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J 28:2018-2027. Abstract Kenzel, S., S. Santos-Sierra, S. D. Deshmukh, I. Moeller, B. Ergin, K. A. Fitzgerald, E. Lien, S. Akira, D. T. Golenbock, and P. Henneke. 2009. Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus. Infect Immun 77:2474-2481. Abstract |
SGBM PhD students
| SGBM PhD students: | Tiago Martins (since September 2022)
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