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Philipp Henneke Profile Page
Philipp Henneke


Lab: Prof. Dr. Philipp Henneke
Department: Center for Chronic Immunodeficiency – CCI
Center of Pediatrics and Adolescent Medicine
Address: Breisacher Straße 117
79106 Freiburg
Phone: +49 761 270-77542
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: 1. Development of cellular innate immunity against commensals of the skin (staphylococci) and respiratory/ intestinal tract (streptococci) at the beginning of life in humans and mice.
2. Receptor-based recognition of bacterial effectors, in particular lipopetides and cytolysins, by macrophages and neutrophils. The particular focus lies on Toll-like receptor signaling and the inflammasome.
3. Cell-fate decisions in monocytes/ macrophages, and the impact of these processes on site specific immunity against bacteria (streptococci, staphylococci, mycobacteria).


Education & Training: 1987 – 1994 Medical School, FU Berlin and Imperial College, London
1994 – 1999 Physician, Center for Pediatrics, FU Berlin
1995 MD, Berlin
Employment & Experience: 2001 – 2002 Instructor/ Assistant Professor, Univ. of Massachusetts, Worcester (USA)
2001 – 2002 Lecturer, Harvard Medical School (Boston)
2003 – 2009 Assistant Professor (W1), Albert-Ludwigs-Universität Freiburg
2005 Habilitation, Pediatrics, Albert-Ludwigs-Universität Freiburg
2005 – 2012 Consultant, Center for Pediatrics and Adolescent Medicine, Freiburg
2008 – 2012 Consultant, Center for Chronic Immunodeficiency (CCI), Freiburg
2009 Call on „W3- Professorship of Infectious Diseases and Immunology“ University of Tübingen (declined)
since 2012 W3- Professor of Infection and Immunity, Albert-Ludwigs-Universität Freiburg Head of Pediatric Infectious Diseases and Rheumatology, Center for Pediatrics and Adolescent Medicine, Freiburg and Center for Chronic Immunodeficiency – CCI, Freiburg


Selected Publications:

Schwab, L., L. Goroncy, S. Palaniyandi, S. Gautam, A. Triantafyllopoulou, A. Mocsai, W. Reichardt, F. J. Karlsson, S. V. Radhakrishnan, K. Hanke, A. Schmitt-Graeff, M. Freudenberg, F. D. von Loewenich, P. Wolf, F. Leonhardt, N. Baxan, D. Pfeifer, O. Schmah, A. Schonle, S. F. Martin, R. Mertelsmann, J. Duyster, J. Finke, M. Prinz, P. Henneke, H. Hacker, G. C. Hildebrandt, G. Hacker, and R. Zeiser. 2014. Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage. Nat Med 20:648-654. Abstract

Landwehr-Kenzel, S., and P. Henneke. 2014. Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease. Front Immunol 5:519. Abstract

Gupta, R., S. Ghosh, B. Monks, R. B. DeOliveira, T. C. Tzeng, P. Kalantari, A. Nandy, B. Bhattacharjee, J. Chan, F. Ferreira, V. Rathinam, S. Sharma, E. Lien, N. Silverman, K. Fitzgerald, A. Firon, P. Trieu-Cuot, P. Henneke, and D. T. Golenbock. 2014. RNA and beta-hemolysin of group B Streptococcus induce interleukin-1beta (IL-1beta) by activating NLRP3 inflammasomes in mouse macrophages. J Biol Chem 289:13701-13705. Abstract

Pannicke, U.*, B. Baumann*, S. Fuchs*, P. Henneke*, A. Rensing-Ehl, M. Rizzi, A. Janda, K. Hese, M. Schlesier, K. Holzmann, S. Borte, C. Laux, E. M. Rump, A. Rosenberg, T. Zelinski, H. Schrezenmeier, T. Wirth, S. Ehl, M. L. Schroeder, and K. Schwarz. 2013. Deficiency of innate and acquired immunity caused by an IKBKB mutation. N Engl J Med 369:2504-2514. * Equal contribution Abstract

Fliegauf, M., A. F. Sonnen, B. Kremer, and P. Henneke. 2013. Mucociliary clearance defects in a murine in vitro model of pneumococcal airway infection. PLoS One 8:e59925. Abstract

Kenzel, S., M. Mergen, J. von Susskind-Schwendi, J. Wennekamp, S. D. Deshmukh, M. Haeffner, A. Triantafyllopoulou, S. Fuchs, S. Farmand, S. Santos-Sierra, J. Seufert, T. K. van den Berg, T. W. Kuijpers, and P. Henneke. 2012. Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase. J Immunol 189:4582-4591. Abstract

Deshmukh, S. D., S. Muller, K. Hese, K. S. Rauch, J. Wennekamp, O. Takeuchi, S. Akira, D. T. Golenbock, and P. Henneke. 2012. NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA. J Immunol 188:774-780. Abstract

Deshmukh, S. D., B. Kremer, M. Freudenberg, S. Bauer, D. T. Golenbock, and P. Henneke. 2011. Macrophages recognize streptococci through bacterial single-stranded RNA. EMBO Rep 12:71-76. Abstract

Santos-Sierra, S., S. D. Deshmukh, J. Kalnitski, P. Kuenzi, M. P. Wymann, D. T. Golenbock, and P. Henneke. 2009. Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J 28:2018-2027. Abstract

Kenzel, S., S. Santos-Sierra, S. D. Deshmukh, I. Moeller, B. Ergin, K. A. Fitzgerald, E. Lien, S. Akira, D. T. Golenbock, and P. Henneke. 2009. Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus. Infect Immun 77:2474-2481. Abstract

SGBM PhD students

SGBM PhD students:

Tiago Martins (since September 2022)

Florens Lohrmann (MD/PhD; since January 2016)

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