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Susana Minguet Profile Page
Susana Minguet


Lab: PD Dr. Susana Minguet
Department: Department of Immunology, Institute of Biology III
Address: Schänzlestr. 18
79104 Freiburg
Phone: +49 (0) 761 203-67514
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: - The molecular mechanisms of early T cell activation and how this knowledge can be used for treatments of human diseases
- The complex interplay between the biophysical properties of the extracellular matrix and T cell infiltration to improve tumor immunotherapy
- The nano-organization of the B cell antigen receptor and the mechanisms by which defective B cell activation leads to immunopathology


Education & Training: 2018: Habilitation in Immunology; University of Freiburg, Germany
2002: PhD degree in Sciences (Biochemistry and Molecular Biology), U.A.M. Madrid, Spain
1997: Bachelor Degree in Chemical Sciences (Biochemistry and Molecular Biology), U.A.M. Madrid, Spain
Employment & Experience: since 2018: Group Leader, Department of Immunology, University of Freiburg
2011-2017: Junior Group Leader, Department of Immunology, University of Freiburg
2008-2011: Research Fellow at CNIC, Madrid, Spain
2002-2007: Postdoctoral Fellow, MPI of Immunobiology, Freiburg


Honors and Awards:

2021: Novartis Prize for Therapy-Relevant Immunological Research by the German Society for Immunology and the Novartis Foundation.
2017: Prize to the best scientific publication from the Center of Chronic Immunodeficiency (CCI)
2016: Baden-Württemberg Stiftung Eliteprogramm
2012: VIII Prize of Health Sciences from Fundación Caja Rural de Granada to the best original investigation of 2012
2009: Award of a 5-year tenure track position, Ramón y Cajal International Program of the Spanish Ministry of Science and Innovation
2003: Prize to the best scientific publication of 2003 from Fundación Médica Mutua Madrileña
1997: PhD Fellowship from the Spanish Ministry of Science and Innovation


Selected Publications:

Hartl FA, Beck-Garcìa E, Woessner NM, Flachsmann LJ, Cárdenas RMV, Brandl SM, Taromi S, Fiala GJ, Morath A, Mishra P, Yousefi OS, Zimmermann J, Hoefflin N, Köhn M, Wöhrl BM, Zeiser R, Schweimer K, Günther S, Schamel WW, Minguet S. Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function. Nat Immunol. 2020 Aug;21(8):902-913.  Abstract

Minguet S, Kläsener K, Schaffer AM, Fiala GJ, Osteso-Ibánez T, Raute K, Navarro-Lérida I, Hartl FA, Seidl M, Reth M, Del Pozo MA. Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance. Nat Immunol. 2017 Oct;18(10):1150-1159.  Abstract

Schamel WW, Alarcon B, Höfer T, Minguet S. The Allostery Model of TCR Regulation. J Immunol. 2017 Jan 1;198(1):47-52.  Abstract

Swamy M, Beck-Garcia K, Beck-Garcia E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnár E, Schulze AK, Blanco R, Borroto A, Martín-Blanco N, Alarcon B, Höfer T, Minguet S, Schamel WW. A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation. Immunity. 2016 May 17;44(5):1091-101.  Abstract

Schönle A, Hartl FA, Mentzel J, Nöltner T, Rauch KS, Prestipino A, Wohlfeil SA, Apostolova P, Hechinger AK, Melchinger W, Fehrenbach K, Guadamillas MC, Follo M, Prinz G, Ruess AK, Pfeifer D, del Pozo MA, Schmitt-Graeff A, Duyster J, Hippen KI, Blazar BR, Schachtrup K, Minguet S, Zeiser R. Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells. Blood. 2016 Apr 14;127(15):1930-9.  Abstract

Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW. Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. J Exp Med. 2015 Sep 21;212(10):1693-708.  Abstract

Goetz JG, Minguet S, Navarro-Lérida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibáñez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, Garcia R, Keely PJ, Sánchez-Mateos P, Cukierman E, Del Pozo MA. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell. 2011 Jul 8;146(1):148-63.  Abstract

Minguet S, Dopfer EP, Pollmer C, Freudenberg MA, Galanos C, Reth M, Huber M, Schamel WW. Enhanced B-cell activation mediated by TLR4 and BCR crosstalk. Eur J Immunol. 2008 Sep;38(9):2475-87.  Abstract

Minguet S, Swamy M, Alarcón B, Luescher IF, Schamel WW. Full activation of the T cell receptor requires both clustering and conformational changes at CD3. Immunity. 2007 Jan;26(1):43-54.  Abstract

Minguet S, Cortegano I, Gonzalo P, Martínez-Marin JA, de Andrés B, Salas C, Melero D, Gaspar ML, Marcos MA. A population of c-Kit(low)(CD45/TER119)- hepatic cell progenitors of 11-day postcoitus mouse embryo liver reconstitutes cell-depleted liver organoids. J Clin Invest. 2003 Oct;112(8):1152-63.  Abstract

SGBM PhD students

SGBM PhD students:

Nadine Wössner (since July 2019)

Simon Brandl (since October 2020)



Katrin Raute (January 2016-May 2020)

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