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Contact
Lab: | PD Dr. Susana Minguet |
Department: | Department of Immunology, Institute of Biology III BIOSS |
Address: | Schänzlestr. 18 79104 Freiburg |
Phone: | +49 (0) 761 203-67514 |
E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
Lab homepage: | www.bioss.uni-freiburg.de/de/pd-dr-susana-minguet/ |
PhD positions available: | YES |
Research Area: | Immunology and Virology |
Research Interests: | - The molecular mechanisms of early T cell activation and how this knowledge can be used for treatments of human diseases - The complex interplay between the biophysical properties of the extracellular matrix and T cell infiltration to improve tumor immunotherapy - The nano-organization of the B cell antigen receptor and the mechanisms by which defective B cell activation leads to immunopathology |
CV
Education & Training: | 2018: Habilitation in Immunology; University of Freiburg, Germany 2002: PhD degree in Sciences (Biochemistry and Molecular Biology), U.A.M. Madrid, Spain 1997: Bachelor Degree in Chemical Sciences (Biochemistry and Molecular Biology), U.A.M. Madrid, Spain |
Employment & Experience: | since 2018: Group Leader, Department of Immunology, University of Freiburg 2011-2017: Junior Group Leader, Department of Immunology, University of Freiburg 2008-2011: Research Fellow at CNIC, Madrid, Spain 2002-2007: Postdoctoral Fellow, MPI of Immunobiology, Freiburg |
Honors
Honors and Awards: | 2021: Novartis Prize for Therapy-Relevant Immunological Research by the German Society for Immunology and the Novartis Foundation. |
Publications
Selected Publications: | Hartl FA, Beck-Garcìa E, Woessner NM, Flachsmann LJ, Cárdenas RMV, Brandl SM, Taromi S, Fiala GJ, Morath A, Mishra P, Yousefi OS, Zimmermann J, Hoefflin N, Köhn M, Wöhrl BM, Zeiser R, Schweimer K, Günther S, Schamel WW, Minguet S. Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function. Nat Immunol. 2020 Aug;21(8):902-913. Abstract Goetz JG, Minguet S, Navarro-Lérida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibáñez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJ, Garcia R, Keely PJ, Sánchez-Mateos P, Cukierman E, Del Pozo MA. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell. 2011 Jul 8;146(1):148-63. Abstract |
SGBM PhD students
SGBM PhD students: | Nadine Wössner (since July 2019) Simon Brandl (since October 2020)
Alumni: Katrin Raute (January 2016-May 2020) |