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Susana Minguet Profile Page
Susana Minguet

Contact

Lab: Dr. Susana Minguet
Department: Molecular Immunology
Institute of Biology/BIOSS
Freiburg University
Address: Schänzlestr. 18
79104 Freiburg
Phone: +49 (0) 761 203-67514
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.bioss.uni-freiburg.de/de/dr-susana-minguet/
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: - The molecular mechanisms of early T cell activation and how this knowledge can be used for treatments of human diseases
- The complex interplay between the biophysical properties of the extracellular matrix and T cell infiltration to improve tumor immunotherapy
- The nano-organization of the B cell antigen receptor and the mechanisms by which defective B cell activation leads to immunopathology

CV

Education & Training: 2002 PhD degree in Sciences (Biochemistry and Molecular Biology), U.A.M. Madrid, Spain
1997 Bachelor Degree in Chemical Sciences (Biochemistry and Molecular Biology), U.A.M. Madrid, Spain
Employment & Experience: University of Freiburg, Faculty of Biology (Germany):
Since July 2011- Junior group Leader T-lymphocyte signalling laboratory
Molecular Immunology Department (Prof. W.W. Schamel)

Centro Nacional de Investigaciones Cardiovasculares Carlos III · CNIC (Madrid, Spain):
2008-2011 Senior Postdoctoral Researcher (Ramón & Cajal Program)
Dr. Miguel Ángel del Pozo group.
Project: Role of caveolin-1 in the Immune System. Homeostasis and hyperactivation.

Max Planck-Institute for Immunobiology and Epigenetics (Freiburg, Germany):
2003-2007 Postdoctoral researcher. Prof. Michael Reth Department. Prof. Wolfgang Schamel group.
Project: Optimal antigen structure for the activation of B and T cells. Activation of Multichain Immune
Recognition Receptors: BCR and TCR

Centro de Biología Molecular Severo Ochoa (Madrid, Spain):
Sep. 1997 – Dec. 2002 Dr. Miguel A. Rodríguez Marcos laboratory.
Pre-Doctoral Fellowship by the Ministerio de Educación y Ciencia.
PhD project: Characterization of a population of hepatic stem cells in the emerging mouse liver.

Amgen, Ontario Cancer Institute (Toronto, Canada):
August - December 1998 – Scientific collaboration. Dr. Tak Mak laboratory.
Project: Role of Notch signaling in the mouse embryo.

Instituto de Catálisis y Petroquímica del CSIC – Biocatalysis section (Madrid, Spain):
September 1996 - March 1997 - Student. Dr. Víctor M. Fernández laboratory.
Project: Kinetic of chemistry equilibrium of deshidrogenases enzymes by using infrared spectroscopy.
Assembled enzymes on gold monolayers to use in biosensors.

REPSOL QUÍMICA S.A. – I&D Center (Madrid, Spain):
July / August 1996 - Student at the Chromatography laboratory.
Project: Statistic studies for the calibration of equipment and analytic methods. GPC. HPLC.

Honors

Honors and Awards:

-VIII Prize of Health Sciences from the Fundación Caja Rural de Granada for the best original investigation and the publication Goetz JG*, Minguet S* et al, Cell 2011 (*Shared first authorship).
-Awarded 5-year tenure track position of the Ramón y Cajal International Program of the Spanish Ministry of Science and Innovation (2009).
-Prize to the best scientific publication 2003 from Fundación Médica Mutua Madrileña to the publication Minguet et al. Journal of Clinical Investigation 2003 (8): 1152

Publications

Selected Publications:

Paensuwan P, Hartl FA, Yousefi OS, Ngoenkam J, Wipa P, Beck-Garcia E, Dopfer EP, Khamsri B, Sanguansermsri D, Minguet S, Schamel WW, Pongcharoen S. “Nck binds to the T Cell Antigen Receptor using its SH3.1 and SH2 domains in a cooperative manner, promoting TCR functioning. J Immunol. 2015 Nov 20. Abstract

Fiala GJ, Janowska I, Prutek, F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S** and Schamel WWA**. “Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. J Exp Med. 2015 Sep 21;212(10):1693-708. ** Equally contributed. Abstract

Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WW. “The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing”. Cell Rep. 2014 (5):1704. Abstract

Ngoenkam J, Paensuwan P, Preechanukul K, Khamsri B, Yiemwattana I, Beck-García E, Minguet S, Schamel WW, Pongcharoen S. Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation. Cell Commun Signal. 2014 (1):21. Abstract

Goetz JG*, Minguet S*, Navarro I, Samaniego R, Tello M, Calvo E, Lazcano JJ, Osteso T, Pellinen T, Echarri A, Cerezo A, Garcia R, Keely PJ, Sánchez-Mateos P, Cukierman E, Del Pozo MA.  Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastais. Cell. 2011 (146):148-63. * Equally contributed. Abstract

Minguet S, Dopfer EP and Schamel WWA. Low valency, but not monovalent, antigens trigger the B cell antigen receptor (BCR). Int Immunol 2010 (22): 205-212. Abstract

Minguet S, Dopfer EP, Pollmer C, Freudenberg MA, Galanos C, Reth M, Huber M, Schamel WW. Enhanced B cell activation mediated by TLR4 and BCR crosstalk. Eur J Imm 2008 (38): 2475-2487. Abstract

Minguet S, Swamy M, Alarcon B, Luescher IF, Schamel WW. Full activation of the T cell receptor requires both clustering and conformational changes at CD3. Immunity. 2007 (1): 43-54. Abstract

Minguet S, Huber M, Rosenkranz L, Schamel WW, Reth M, Brummer T. Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors. Eur J Immunol. 2005 (1):31-41. Abstract

Minguet S, Gonzalo P, Martínez-M JA, de Andrés B, Salas C, Gaspar ML, Marcos MAR. A population of c-Kitlow(CD45/TER119)- hepatic cell progenitors of 11-dpc mouse embryo liver reconstitutes cell-depleted liver organoids. J. Clin. Invest. 2003 (8): 1152. Abstract

SGBM PhD students

SGBM PhD students:

Track 1:

Katrin Raute (since January 2016)

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