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Contact
Lab: | Prof. Dr. Sven Diederichs |
Department: | Medical Center - Department of Thoracic Surgery Division of Cancer Research |
Address: | Breisacher Str. 115 79106 Freiburg |
E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
Lab homepage: | www.uniklinik-freiburg.de/cancer-research/ |
PhD positions available: | YES |
Research Area: | Molecular Medicine |
Research Interests: | - Cancer Genetics & Non-canonical Mutations - Understanding molecular mechanisms of lung cancer and metastasis - Focus on RNA Biology and long non-coding RNAs - Approaches of Molecular Biology, Cell Biology & Bioinformatics |
CV
Education & Training: | 02/2002 - 07/2004: Graduate Student with Prof. Dr. Hubert Serve / PD Dr. Carsten Müller-Tidow, Dept. of Internal Medicine A, University of Münster & Prof. Dr. Kurt S. Zänker, Dept. of Immunology, University Witten / Herdecke: „The functional role of cell cycle regulators in the tumorigenic process“ Grade: „summa cum laude“ (Dr. rer. nat.; July 8th, 2004) 09/2001 - 01/2002: Diploma Student with Prof. Dr. Hubert Serve / PD Dr. Carsten Müller-Tidow, Dept. of Internal Medicine A (Hematology/Oncology), University of Münster 1999-2001: University Witten / Herdecke Biochemistry (Final Exam – Diplom); Grade: „excellent“ (1.0) 02/2001 - 04/2001: Research Internship: Prof. Dr. A. Ullrich, Max-Planck-Institute for Biochemistry 02/2000 - 04/2000: Research Internship: Prof. Dr. S.R. Pfeffer , Stanford University 1996-1999: Eberhard-Karls-University Tübingen Biochemistry (Intermediate exam – Vordiplom); Grade: „very good“ (1.2) 03/1999 - 04/1999 & 07/1998 - 10/1998: Research Internship: Prof. Dr. H. P. Koeffler, Cedars Sinai Research Center / UCLA School of Medicine, Los Angeles |
Employment & Experience: | since 01/2016: University Professor (W3) for Cancer Research in the Clinic for Thoracic Surgery, University Hospital Freiburg since 01/2015: Tenured Division Head for „RNA Biology & Cancer“ at the German Cancer Research Center, Heidelberg (2015: joint with Institute of Pathology, Univ. HD) 07/2008 - 12/2014: Leader of the independent Helmholtz-University-Junior Research Group „Molecular RNA Biology & Cancer“ at the German Cancer Research Center (DKFZ) and the Institute of Pathology, University Hospital Heidelberg 01/2005 - 05/2008: Postdoctoral Fellow with Prof. Dr. Daniel A. Haber, Harvard Medical School & Massachusetts General Hospital Cancer Center, Boston, U.S.A. 07/2004 - 12/2004: Postdoctoral Fellow in the Dept. of Internal Medicine A, University of Münster |
Scientific Activities: | since 2021: Speaker of the DKTK Program "Exploitation of Oncogenic Mechanisms (EOM) since 01/2016: Member of the German Cancer Consortium (DKTK), Freiburg 09/2014: Co-Organizer of the ESF - EMBO - Symposium on „Long Regulatory RNAs” in Pultusk, Poland 06/2014: Organizer of the International Meeting of RNA@DKFZ & CellNetworks EcTop5: „Non-coding RNA - From Basic Mechanisms to Cancer”, Heidelberg since 2012: Member of the Excellence Cluster CellNetworks 09/2011: Organizer of the 12th Young Scientist Meeting of the German Society of Cell Biology (DGZ), on „RNA & Disease“, Jena since 2011: Associate Editor (RNA & Disease) of the journal RNA Biology 2010-2015: Member of the Young Academy (Junge Akademie) at the Berlin-Brandenburg Academy of Sciences and the National Academy of Scientists Leopoldina since 2009: Member of the Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS) Memberships RNA Society, American Association for Cancer Research (AACR), Society for Molecular Biology & Biochemistry (GBM), German Society of Pathology (DGP), German Society of Cell Biology (DGZ), German Association of University Professors (DHV) since 2009: Reviewer for national and international funding agencies European Research Council (ERC-AdG, ERC-CoG, ERC-StG,); American Association for Cancer Research (AACR / KWF SU2C); Cancer Research UK (CRUK); Medical Research Council UK (MRC); British Council (BIRAX); German Research Foundation (DFG); German Cancer Aid (DKH); Association for International Cancer Research (AICR); Israel Science Foundation (ISF); German Insraeli Foundation (GIF); Institut National du Cancer (INCa, France); Swiss National Fund (SNF); Netherlands Organisation for Scientific Research (NWO); Fonds National de la Recherche Luxembourg (FRN); Pediatric Oncology Foundation Groningen (SKOG); Estonian Science Foundation (ESF); University of Düsseldorf; University of Halle / Wittenberg since 2007: Reviewer for scientific journals Nature; Nature Genetics; Nature Cell Biology; Nature Medicine; Nature Structural Molecular Biology; Nature Communications; Nature Chemical Biology; Science Signaling; Molecular Cell; Cell Reports; EMBO Molecular Medicine; PLoS Biology; PLoS Genetics; Genome Research; Genome Biology; Journal of Clinical Investigation; Cancer Discovery; Cancer Research; Oncogene; Nucleic Acids Research; RNA; RNA Biology; FEBS Journal; Cell Research; Hepatology; Journal of Hepatology; International Journal of Cancer; Molecular Cancer Research; Cancer Letters; Biochimie; Biochimica Biophysica Acta; Trends in Cell Biology; Trends in Biotechnology; Journal of Pathology; American Journal of Pathology; BMC Molecular Biology; BMC Clinical Pathology; Neuropathology & Applied Neurobiology; Frontiers in Neuromethods; PLoS ONE |
Honors
Honors and Awards: | 2016 Anniversary Prize of the Federation of European Biochemical Societies (FEBS) |
Publications
Selected Publications: | Dhamija S, Yang CM, Seiler J, Myacheva K, Caudron-Herger M, Wieland A, Abdelkarim M, Sharma Y, Riester M, Groß M, Maurer J, Diederichs S. A pan-cancer analysis reveals nonstop extension mutations causing SMAD4 tumour suppressor degradation. Nat Cell Biol. 2020 Jul 27. Abstract Sharma Y, Miladi M, Dukare S, Boulay K, Caudron-Herger M, Groß M, Backofen R, Diederichs S. A pan-cancer analysis of synonymous mutations. Nat Commun. 2019 Jun 12;10(1):2569. Abstract |