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Sven Diederichs


Lab: Prof. Dr. Sven Diederichs
Department: Medical Center - Department of Thoracic Surgery
Division of Cancer Research
Address: Breisacher Str. 115
79106 Freiburg
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: - Cancer Genetics & Non-canonical Mutations
- Understanding molecular mechanisms of lung cancer and metastasis
- Focus on RNA Biology and long non-coding RNAs
- Approaches of Molecular Biology, Cell Biology & Bioinformatics


Education & Training: 02/2002 - 07/2004: Graduate Student with Prof. Dr. Hubert Serve / PD Dr. Carsten Müller-Tidow, Dept. of Internal Medicine A, University of Münster & Prof. Dr. Kurt S. Zänker, Dept. of Immunology, University Witten / Herdecke: „The functional role of cell cycle regulators in the tumorigenic process“
Grade: „summa cum laude“ (Dr. rer. nat.; July 8th, 2004)
09/2001 - 01/2002: Diploma Student with Prof. Dr. Hubert Serve / PD Dr. Carsten Müller-Tidow, Dept. of Internal Medicine A (Hematology/Oncology), University of Münster
1999-2001: University Witten / Herdecke
Biochemistry (Final Exam – Diplom); Grade: „excellent“ (1.0)
02/2001 - 04/2001: Research Internship: Prof. Dr. A. Ullrich, Max-Planck-Institute for Biochemistry
02/2000 - 04/2000: Research Internship: Prof. Dr. S.R. Pfeffer , Stanford University
1996-1999: Eberhard-Karls-University Tübingen
Biochemistry (Intermediate exam – Vordiplom); Grade: „very good“ (1.2)
03/1999 - 04/1999 & 07/1998 - 10/1998: Research Internship: Prof. Dr. H. P. Koeffler, Cedars Sinai Research Center / UCLA School of Medicine, Los Angeles
Employment & Experience: since 01/2016: University Professor (W3) for Cancer Research in the Clinic for Thoracic Surgery, University Hospital Freiburg
since 01/2015: Tenured Division Head for „RNA Biology & Cancer“ at the German Cancer Research Center, Heidelberg (2015: joint with Institute of Pathology, Univ. HD)
07/2008 - 12/2014: Leader of the independent Helmholtz-University-Junior Research Group „Molecular RNA Biology & Cancer“ at the German Cancer Research Center (DKFZ) and the Institute of Pathology, University Hospital Heidelberg
01/2005 - 05/2008: Postdoctoral Fellow with Prof. Dr. Daniel A. Haber, Harvard Medical School & Massachusetts General Hospital Cancer Center, Boston, U.S.A.
07/2004 - 12/2004: Postdoctoral Fellow in the Dept. of Internal Medicine A, University of Münster
Scientific Activities: since 2021: Speaker of the DKTK Program "Exploitation of Oncogenic Mechanisms (EOM)
since 01/2016: Member of the German Cancer Consortium (DKTK), Freiburg
09/2014: Co-Organizer of the ESF - EMBO - Symposium on „Long Regulatory RNAs” in Pultusk, Poland
06/2014: Organizer of the International Meeting of RNA@DKFZ & CellNetworks EcTop5: „Non-coding RNA - From Basic Mechanisms to Cancer”, Heidelberg
since 2012: Member of the Excellence Cluster CellNetworks
09/2011: Organizer of the 12th Young Scientist Meeting of the German Society of Cell Biology (DGZ), on „RNA & Disease“, Jena
since 2011: Associate Editor (RNA & Disease) of the journal RNA Biology
2010-2015: Member of the Young Academy (Junge Akademie) at the Berlin-Brandenburg Academy of Sciences and the National Academy of Scientists Leopoldina

since 2009: Member of the Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS)
Memberships RNA Society, American Association for Cancer Research (AACR), Society for Molecular Biology & Biochemistry (GBM), German Society of Pathology (DGP), German Society of Cell Biology (DGZ), German Association of University Professors (DHV)

since 2009: Reviewer for national and international funding agencies
European Research Council (ERC-AdG, ERC-CoG, ERC-StG,); American Association for Cancer Research (AACR / KWF SU2C); Cancer Research UK (CRUK); Medical Research Council UK (MRC); British Council (BIRAX); German Research Foundation (DFG); German Cancer Aid (DKH); Association for International Cancer Research (AICR); Israel Science Foundation (ISF); German Insraeli Foundation (GIF); Institut National du Cancer (INCa, France); Swiss National Fund (SNF); Netherlands Organisation for Scientific Research (NWO); Fonds National de la Recherche Luxembourg (FRN); Pediatric Oncology Foundation Groningen (SKOG); Estonian Science Foundation (ESF); University of Düsseldorf; University of Halle / Wittenberg

since 2007: Reviewer for scientific journals
Nature; Nature Genetics; Nature Cell Biology; Nature Medicine; Nature Structural Molecular Biology; Nature Communications; Nature Chemical Biology; Science Signaling; Molecular Cell; Cell Reports; EMBO Molecular Medicine; PLoS Biology; PLoS Genetics; Genome Research; Genome Biology; Journal of Clinical Investigation; Cancer Discovery; Cancer Research; Oncogene; Nucleic Acids Research; RNA; RNA Biology; FEBS Journal; Cell Research; Hepatology; Journal of Hepatology; International Journal of Cancer; Molecular Cancer Research; Cancer Letters; Biochimie; Biochimica Biophysica Acta; Trends in Cell Biology; Trends in Biotechnology; Journal of Pathology; American Journal of Pathology; BMC Molecular Biology; BMC Clinical Pathology; Neuropathology & Applied Neurobiology; Frontiers in Neuromethods; PLoS ONE


Honors and Awards:

2016 Anniversary Prize of the Federation of European Biochemical Societies (FEBS)
09/2014 Junior Research Award Liver Cancer 2014 of the German Society for Gastrointestinal Diseases (DGVS) & Bayer HealthCare
2013 Dr. Hella Bühler-Award for Cancer Research endowed with 100.000 Euro
03/2012 Binder Innovation Award 2012 of the German Society of Cell Biology (DGZ)
06/2010 Karl-Freudenberg-Prize 2010 of the Heidelberg Academy of Sciences
06/2010 Elected into the Young Academy of Scientists (Junge Akademie) at the Berlin- Brandenburg Academy of Sciences and the German National Academy of Scientists Leopoldina
02/2008 Presentation Award Miami Winter Symposium „Regulatory RNA in Biology and human Health“
10/2007 Scholar-in-Training Award of the American Association for Cancer Research (AACR): „Non-Coding RNAs in Cancer“
10/2005 Leopoldina-Prize for young scientists of the German National Academy of Scientists Leopoldina
10/2005 PhD Award of the German Society of Hematology and Oncology (DGHO)
04/2003 Scholar-in-Training Award of the American Association for Cancer Research (AACR) and the Pezcoller Foundation
02/1997 - 12/2001 Scholarship of the German Academic Merit Foundation (Studienstiftung des deutschen Volkes)


Selected Publications:

Dhamija S, Yang CM, Seiler J, Myacheva K, Caudron-Herger M, Wieland A, Abdelkarim M, Sharma Y, Riester M, Groß M, Maurer J, Diederichs S. A pan-cancer analysis reveals nonstop extension mutations causing SMAD4 tumour suppressor degradation. Nat Cell Biol. 2020 Jul 27.  Abstract

Gandhi M, Groß M, Holler JM, Coggins SA, Patil N, Leupold JH, Munschauer M, Schenone M, Hartigan CR, Allgayer H, Kim B, Diederichs S. The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer. Nat Commun. 2020 Jun 25;11(1):3214.  Abstract

Caudron-Herger M, Wassmer E, Nasa I, Schultz AS, Seiler J, Kettenbach AN, Diederichs S. Identification, quantification and bioinformatic analysis of RNA-dependent proteins by RNase treatment and density gradient ultracentrifugation using R-DeeP. Nat Protoc. 2020 Apr;15(4):1338-1370.  Abstract

Sharma Y, Miladi M, Dukare S, Boulay K, Caudron-Herger M, Groß M, Backofen R, Diederichs S. A pan-cancer analysis of synonymous mutations. Nat Commun. 2019 Jun 12;10(1):2569.  Abstract

Caudron-Herger M, Rusin SF, Adamo ME, Seiler J, Schmid VK, Barreau E, Kettenbach AN, Diederichs S. R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation. Mol Cell. 2019 Jul 11;75(1):184-199.e10.  Abstract

Goyal A, Myacheva K, Groß M, Klingenberg M, Duran Arqué B, Diederichs S. Challenges of CRISPR/Cas9 applications for long non-coding RNA genes. Nucleic Acids Res. 2017 Feb 17;45(3):e12.  Abstract

Diederichs S, Bartsch L, Berkmann JC, Fröse K, Heitmann J, Hoppe C, Iggena D, Jazmati D, Karschnia P, Linsenmeier M, Maulhardt T, Möhrmann L, Morstein J, Paffenholz SV, Röpenack P, Rückert T, Sandig L, Schell M, Steinmann A, Voss G, Wasmuth J, Weinberger ME, Wullenkord R. The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations. EMBO Mol Med. 2016 May 2;8(5):442-57.  Abstract

Hämmerle M, Gutschner T, Uckelmann H, Ozgur S, Fiskin E, Gross M, Skawran B, Geffers R, Longerich T, Breuhahn K, Schirmacher P, Stoecklin G, Diederichs S. Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1). Hepatology. 2013 Nov;58(5):1703-12.  Abstract

Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 2013 Feb 1;73(3):1180-9.  Abstract

Diederichs S, Haber DA. Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell. 2007 Dec 14;131(6):1097-108.  Abstract

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