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Soeren Lienkamp Profile Page
Soeren Lienkamp

Contact

Lab: Dr. Soeren Lienkamp
Department: University Medical Center
Address: Center for Clinical Research (ZKF)
Breisacher Strasse 66
79106 Freiburg
Phone: +49 761 27033630
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.nephrolab.org/groups/soeren-lienkamp/
BIOSS Excellence Cluster : Associated member
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: - Molecular understanding of renal morphogenesis
- Identification and characterization of proteins associated with genetic forms of cystic kidney disease and renal developmental disorders
- Transcriptional control of tubule cell identity

CV

Education & Training: 09/2002 - 06/2007: MD thesis (summa cum laude), University Freiburg, advisor: Prof. Dr. Joachim Gloy
10/2003 - 09/2004: Research student, Nagoya University (名古屋大学), Japan (advisor: Prof. Kunihiro Matusmoto)
10/1999 - 06/2007: Medical School, University Freiburg
1998: Abitur, Carl-Humann-Gymnasium, Essen-Steele
Employment & Experience: 2006 – 2011 Postdoc and Clinical Resident, Department of Nephrology, University Hospital Freiburg, Director: Prof. Dr. Gerd Walz
2011 – 2014 Junior-group leader within the clinical research unit KFO 201 (Polycystic Disease – From Model Organisms to Novel Therapies)
since 2014 Emmy-Noether-group leader, Department of Nephrology, University Hospital Freiburg
Scientific Activities: since 2014 Project leader of the SFB 1140 (Kidney Disease – from Genes to Mechanisms)

Honors

Honors and Awards:

2015: Heinz Maier-Leibnitz Preis of the German Research Community (DFG)
2014: Emmy-Noether Group Leader (DFG funded)
2013: Theodor-Frerichs-Award of the German Society for Internal Medicine (DGIM)
2011: Member of the DFG funded Clinical Research Unit (KFO 201) - Polycystic Disease – From Model Organisms to Novel Therapies
2007: Young Researchers Award of Freiburg University (Pfizer Preis für Nachwuchswissenschaftler)
2003: AIEJ Scholarship, Ministry of Education, Japan

Publications

Selected Publications:

Kaminski, M.M., Tosic J., Kresbach, C., Engel, H., Klockenbusch, J., Müller, A.-L., Pichler, R., Grahammer, F., Kretz, O., Huber, T.B., Walz, G., Arnold, S.J.*, Lienkamp, S.S.* (2016). Direct Reprogramming of Fibroblasts into Renal Tubular Epithelial Cells by Defined Transcription Factors. Nat Cell Biol, Dec;18(12):1269-1280.  * corresponding authors  Abstract

Yasunaga T, Hoff S, Schell C, Helmstädter M, Kretz O, Kuechlin S, Yakulov TA, Engel C, Müller B, Bensch R, Ronneberger O, Huber TB, Lienkamp SS, Walz G. The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells. J Cell Biol. 2015 Dec 7;211(5):963-73. Abstract

Vivante A, Kleppa MJ, Schulz J, Kohl S, Sharma A, Chen J, Shril S, Hwang DY, Weiss AC, Kaminski MM, Shukrun R, Kemper MJ, Lehnhardt A, Beetz R, Sanna-Cherchi S, Verbitsky M, Gharavi AG, Stuart HM, Feather SA, Goodship JA, Goodship TH, Woolf AS, Westra SJ, Doody DP, Bauer SB, Lee RS, Adam RM, Lu W, Reutter HM, Kehinde EO, Mancini EJ, Lifton RP, Tasic V, Lienkamp SS, Jüppner H, Kispert A, Hildebrandt F. Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development. Am J Hum Genet. 2015 Aug 6;97(2):291-301.  Abstract

Funk MC, Bera AN, Menchen T, Kuales G, Thriene K, Lienkamp SS, Dengjel J, Omran H, Frank M, Arnold SJ. Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells. EMBO J. 2015 Apr 15;34(8):1078-89.  Abstract

Epting D, Slanchev K, Boehlke C, Hoff S, Loges NT, Yasunaga T, Indorf L, Nestel S, Lienkamp SS, Omran H, Kuehn EW, Ronneberger O, Walz G, Kramer-Zucker A. The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Development. 2015 Jan 1;142(1):174-84.  Abstract

Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp SS. ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nat Genet. 2013 Aug;45(8):951-6.  Abstract

Lienkamp SS, Liu K, Karner CM, Carroll TJ, Ronneberger O, Wallingford JB, Walz G. Vertebrate kidney tubules elongate using a planar cell polarity-dependent, rosette-based mechanism of convergent extension. Nat Genet. 2012 Dec;44(12):1382-7.  Abstract

Lienkamp S, Ganner A, Boehlke C, Schmidt T, Arnold SJ, Schäfer T, Romaker D, Schuler J, Hoff S, Powelske C, Eifler A, Krönig C, Bullerkotte A, Nitschke R, Kuehn EW, Kim E, Burkhardt H, Brox T, Ronneberger O, Gloy J, Walz G. Inversin relays Frizzled-8 signals to promote proximal pronephros development. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20388-93.  Abstract

Ganner A, Lienkamp S, Schäfer T, Romaker D, Wegierski T, Park TJ, Spreitzer S, Simons M, Gloy J, Kim E, Wallingford JB, Walz G. Regulation of ciliary polarity by the APC/C. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17799-804.  Abstract

Bergmann C, Fliegauf M, Brüchle NO, Frank V, Olbrich H, Kirschner J, Schermer B, Schmedding I, Kispert A, Kränzlin B, Nürnberg G, Becker C, Grimm T, Girschick G, Lynch SA, Kelehan P, Senderek J, Neuhaus TJ, Stallmach T, Zentgraf H, Nürnberg P, Gretz N, Lo C, Lienkamp S, Schäfer T, Walz G, Benzing T, Zerres K, Omran H. Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet. 2008 Apr;82(4):959-70.  Abstract

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