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Simone Hettmer Profile Page
Simone Hettmer


Lab: Dr. Simone Hettmer
Department: University Medical Center
Address: Center of Pediatrics and Adolescent Medicine
Mathildenstr. 1
D-79106 Freiburg
Phone: +49 761 27045140
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: Research in our lab aims at a better understanding of cellular and molecular drivers of sarcoma initiation and maintenance through:
- characterization of the sarcoma-initiating capacities of mesodermal precursor cell populations
- investigation of the genetic basis of sarcoma susceptibility
- development of sarcoma test platforms in vitro and in mice


Education & Training: 07/2007-06/2009: Postdoctoral fellow - Section on Developmental and Stem Cell Biology / Joslin Diabetes Center, Boston, MA
07/2006-06/2009: Fellow - Dana-Farber Cancer Institute / Children's Hospital Boston, Boston, MA
06/2003-06/2006: Intern/Resident - Massachusetts General Hospital, Boston, MA
01/2001-05/2003: Research fellow - Center for Cancer and Immunology Research, Children's Research Institute, Washington D.C.
06/1999-11/2000: Arztin im Praktikum - Zentrum für Kinderheilkunde der Rheinischen Friedrich-Wilhelms-Universität Bonn, Germany
1999: Medicine degree - Eberhard-Karls Universität, Tübingen, Germany
Employment & Experience: Since 11/2014: Attending, Group leader - University Medical Center Freiburg, Germany
02/2014-10/2014: Staff scientist, Hospitalist - Charite, University Hospital, Berlin, Germany
07/2009-01/2014: Attending - Brigham and Women's Hospital, Boston MA; Children 's Hospital Boston, Boston, MA; Dana-Farber Cancer Institute, Boston, MA


Honors and Awards:

2013: Career Development Award - Sarcoma Alliance for Research through Collaboration

2012: Travel Award - Pediatric Cancer Translational Genomics Conference, Phoenix, AZ (One of the 10 best posters at the conference)

2011: Poster Prize - Gordon Conference (Stem Cells & Cancer), Ventura, CA (One of the 3 best posters at the conference)

2010-2012: Career Development Award - Alex's Lemonade Stand Foundation (Target identification in rhabdomyosarcoma)

2010: Patient Safety Award - Dana-Farber Cancer Institute

2008-2010: Research Fellowship - Hope Street Kids Foundation

2008-2011: Research Fellowship - St. Baldrick s Foundation

2001-2002: Research Fellowship - Dr.-Mildred-Scheei-Stiftung/Deutsche Krebshilfe (German Cancer Foundation)


Selected Publications:

S Hettmer, AC Schinzel, D Tchessalova, M Schneider, CL Parker, R Bronson, NG Richards, W Hahn, AJ Wagers. Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. Epub Elife. 2015 Oct 24;4.  Abstract

S Hettmer, MM Lin, D Tchessalova, SJ Tortorici, A Castiglioni, T Desai, J Mao, AP McMahon, AJ Wagers. Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity. Exp Cell Res. Epub 2015 Oct 9.  Abstract

S Hettmer*, RT Bronson, AJ Wagers. Distinct malignant behaviors of mouse myogenic tumors induced by different oncogenetic lesions. Frontiers in Oncology. 2015 Feb 24; 5:50.  Abstract

AM Tremblay, E Missiaglia, GG Galli, S Hettmer, R Urcia, M Carrara, RN Judson, K Thway, G Nadal, JL Selfe, G Murray, RA Calogero, C De Bari, PS Zammit, M Delorenzi, AJ Wagers, J Shipley, H Wackerhage and FD Camargo. The Hippo Transducer YAP1 Transforms Activated Satellite Cells and is a Potent Effector of Embryonal Rhabdomyosarcoma Formation. Cancer Cell. 2014 Aug 11;26(2):273-87.  Abstract

K Kikuchi, S Hettmer, MI Aslam, JE Michalek, W Laub, BP Rubin, AJ Wagers, C Keller. Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma. PLOS Genetics. 2014;10(1):e1004107.  Abstract

A Castiglioni* and S Hettmer*, MD Lynes, TN Rao, D Tchessaolova, I Sinha, BT Lee, YH Tseng, AJ Wagers. Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence activated cell sorting from human fetal muscle. Stem Cell Reports. 2014;2(1):92-106 (* shared first authorship).  Abstract

S Hettmer*, LA Teot, P van Hummelen, L MacConaill, RT Bronson, C Dall’Osso, J Mao, AP McMahon, PJ Gruber, HE Grier, C Rodriguez-Galindo, CD Fletcher, AJ Wagers. Mutations in Hedgehog pathway genes in fetal rhabdomyoma. The Journal of Pathology. 2013;231(1):44-52.  Abstract

J Liu, S Hettmer, MD Milsom, I Hofmann, F Hua, C Miller, RT Bronson, AJ Wagers. Induction of Histiocytic Sarcoma in Mouse Skeletal Muscle. PLOS One. 2012;7(8):e44044.  Abstract

S Hettmer, J Liu, CM Miller, MC Lindsay, CA Sparks, DA Guertin, RT Bronson, DM Langenau, AJ Wagers. Sarcomas induced in discrete subsets of prospectively isolated mouse skeletal muscle cells. Proc. Natl Acad Sci., U.S.A.; 2011; 108(50): 20002-7.  Abstract

S. Hettmer, A.Wagers. Muscling in: Uncovering the origins of rhabdomyosarcoma. Nature Medicine. 2010:16(2):171-3.  Abstract

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