You are here: Home Our Members Principal Investigators
Edward Pearce Profile Page
Edward Pearce

Contact

Lab: Dr. Edward Pearce
Department: Max Planck Institute of Immunobiology and Epigenetics
Address: Stübeweg 51
79108 Freiburg
Phone: 0049 761 5108 476
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.ie-freiburg.mpg.de/pearceed
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: Metabolic reprogramming during immune cell activation; Type 2 immunity; immunity to parasitic infections; immunity to cancer.

CV

Education & Training: 1980-1983: Ph.D., Parasitology, Division of Parasitology, National Institute for Medical Research, Mill Hill, London, UK. Degree awarded by Brunel University
1977-1980: B.S., Zoology, University of Wales, Aberystwyth, Dyfed Wales, UK
Employment & Experience: 2015- : Senior Group Leader, Max Planck Institute of Immunobiology and Epigenetics, and Professor, Faculty of Biology, University of Freiburg, Freiburg, Germany.
2011-2015: Professor of Pathology & Immunology, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO
2010-2011: Chief Scientific Officer, Trudeau Institute, Saranac Lake, NY, USA
2009-2011: Member, Trudeau Institute, Saranac Lake, NY, USA
2004-2009: Professor (with tenure) Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
2001-2009: Director, Veterinary Center for Infectious Disease Research, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
2001-2003: Associate Professor (with tenure), Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
1999-2000: Acting Co-Chair, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
1998-2001: Co-Director, Biology of Parasitism, Marine Biological Laboratory, Woods Hole, MA, USA
1997-2001: Associate Professor (with tenure), Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
1991-1997: Assistant Professor, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
1990-1991: Visiting Scientist, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA
1987-1990: Visiting Associate, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA
1985-1987: Guest Researcher, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA
1983-1985: Visiting Fellow, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA

Honors

Honors and Awards:

2013: Fellow of the American Academy of Microbiology

2002: Recipient of American Society of Tropical Medicine and Hygiene’s Bailey K. Ashford Medal

2001: Scholar Award in Molecular Parasitology, Burroughs Wellcome Fund

1994: New Investigator Award, Burroughs Wellcome Fund

Publications

Selected Publications:

Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ. Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation. Immunity. 2016 Oct 18;45(4):817-830.  Abstract

Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metab. 2016 Jul 12;24(1):158-66.  Abstract

Wu D, Sanin DE, Everts B, Chen Q, Qiu J, Buck MD, Patterson A, Smith AM, Chang CH, Liu Z, Artyomov MN, Pearce EL, Cella M, Pearce EJ. Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function. Immunity. 2016 Jun 21;44(6):1325-36.  Abstract

Everts B, Tussiwand R, Dreesen L, Fairfax KC, Huang SC, Smith AM, O'Neill CM, Lam WY, Edelson BT, Urban JF Jr, Murphy KM, Pearce EJ. Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12. J Exp Med. 2016 Jan 11;213(1):35-51.  Abstract

Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJ, Tonc E, Schreiber RD, Pearce EJ, Pearce EL. Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression. Cell. 2015 Sep 10;162(6):1229-41.  Abstract

Tussiwand R, Everts B, Grajales-Reyes GE, Kretzer NM, Iwata A, Bagaitkar J, Wu X, Wong R, Anderson DA, Murphy TL, Pearce EJ, Murphy KM. Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity. 2015 May 19;42(5):916-28.  Abstract

Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity. 2015 Mar 17;42(3):419-30.  Abstract

Huang SC, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O'Neill CM, Yan C, Du H, Abumrad NA, Urban JF Jr, Artyomov MN, Pearce EL, Pearce EJ. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat Immunol. 2014 Sep;15(9):846-55.  Abstract

Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation. Nat Immunol. 2014 Apr;15(4):323-32.  Abstract

Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood. 2010 Jun 10;115(23):4742-9.  Abstract

Copyright © 2009-2020 University of Freiburg