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Ian Frew Profile Page
Ian Frew


Lab: Prof. Ian Frew
Department: Clinic of Internal Medicine I
University Medical Center Freiburg
Phone: +49 761 270 71831
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: - Understanding how combinations of genetic mutations affect tumour phenotypes and responses to therapies
- Development and use of novel genetic tools allowing high throughput genetics to model complex human tumours in mice
- Genetic and chemical library screening to identify novel mutation-specific therapeuties


Education & Training: 1998-2003: PhD at Peter MacCallum Cancer Centre, University of Melbourne, Australia
1994-1997: BSc(Hons) in Molecular Biology and Biochemistry, Australian National University, Canberra, Australia
Employment & Experience: 2010-2016: Assistant Professorship of the Swiss National Science Foundation and Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland
2003-2009: Postdoctoral research fellow (Prof. Wilhelm Krek), Institute of Cell Biology, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland
Scientific Activities: 2010-2016: Project leader in Swiss National Science Foundation National Competence Centre of Research Kidney. CH programme
2010-2016: Member of Zurich Center for Integrative Human Physiology (ZIHP), Cancer Network Zurich (CNZ) and Competence Center Personalized Medicine programmes.
2011-2016: Steering Committee Member of the Zurich Integrative Rodent Physiology (ZIRP) center
2011-2012: Established the ZIRP Rodent Imaging Platform at the University of Zurich.


Honors and Awards:

2010-2015: ERC Starting Grant
2003-2005: Serono Foundation for the Advancement of Medical Science Postdoctoral Fellowship in Cancer Biology
2003: Peter MacCallum Cancer Centre Postgraduate Research Medal
1998-2002: Sir Russell Grimwade PhD scholarship, University of Melbourne
1997: University Medal in Biochemistry and Molecular Biology, Australian National University


Selected Publications:

Schönenberger D, Rajski M, Harlander S, Frew IJ. Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis. Oncotarget. 2016 Sep 20;7(38):60971-60985.  Abstract

Guinot A, Lehmann H, Wild PJ, Frew IJ. Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions. J Pathol. 2016 Jul;239(3):365-73.  Abstract

Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ. Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α. Cancer Res. 2016 Apr 1;76(7):2025-36.  Abstract

Albers J, Danzer C, Rechsteiner M, Lehmann H, Brandt LP, Hejhal T, Catalano A, Busenhart P, Gonçalves AF, Brandt S, Bode PK, Bode-Lesniewska B, Wild PJ, Frew IJ. A versatile modular vector system for rapid combinatorial mammalian genetics. J Clin Invest. 2015 Apr;125(4):1603-19.  Abstract

Lehmann H, Vicari D, Wild PJ, Frew IJ. Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation. J Am Soc Nephrol. 2015 Nov;26(11):2778-88.  Abstract

Albers J, Rajski M, Schönenberger D, Harlander S, Schraml P, von Teichman A, Georgiev S, Wild PJ, Moch H, Krek W, Frew IJ. Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice. EMBO Mol Med. 2013 Jun;5(6):949-64.  Abstract

Wild PJ, Ikenberg K, Fuchs TJ, Rechsteiner M, Georgiev S, Fankhauser N, Noske A, Roessle M, Caduff R, Dellas A, Fink D, Moch H, Krek W, Frew IJ. p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans. EMBO Mol Med. 2012 Aug;4(8):808-24.  Abstract

Frew IJ, Thoma CR, Georgiev S, Minola A, Hitz M, Montani M, Moch H, Krek W. pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J. 2008 Jun 18;27(12):1747-57.  Abstract

Frew IJ, Minola A, Georgiev S, Hitz M, Moch H, Richard S, Vortmeyer AO, Krek W. Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Mol Cell Biol. 2008 Jul;28(14):4536-48.  Abstract

Thoma CR*, Frew IJ*, Hoerner CR, Montani M, Moch H, Krek W. pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nat Cell Biol. 2007 May;9(5):588-95. *equal contribution  Abstract

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