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Maja Köhn Profile Page
Maja Köhn


Lab: Prof. Maja Köhn
Department: BIOSS Centre for Biological Signalling Studies
Institute of Biology III
Address: Schänzlestr. 18
79104 Freiburg
Phone: +49-761 203 67900
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
PhD positions available: YES
Research Area: Protein Structure and Function
Research Interests: -Elucidation of the functions and molecular mechanisms of the cancer-promoting phosphatase PRL-3 and the ubiquitous phosphatase PP1
-Development of inhibitors and activators for phosphatases


Education & Training: 2002–2005: Dr. rer. nat. in Organic Chemistry, Technical University Dortmund and MPI for Molecular Physiology (supervisor: Prof. H. Waldmann)
1996–2001: Diploma in Chemistry, Christian-Albrechts-University, Kiel, Germany
Employment & Experience: Since 2016: Full Professor (W3) for Integrative Signaling Studies, University of Freiburg
2007–2016: Group leader, European Molecular Biology Laboratory, Heidelberg
2005–2007: Postdoctoral researcher, Harvard University, Cambridge, USA (supervisor: Prof. G. L. Verdine)
Scientific Activities: 2008,10,12,14,16: EMBO conference series: Chemical Biology, Heidelberg, Organizer
Since 2016: Editorial Advisory Board of Bioorganic and Medicinal Chemistry
Since 2016: Editorial Advisory Board of ACS Chemical Biology
2015: Guest Editor: ‘Chemistry and biology of protein and inositol phosphorylation’, Bioorg. Med. Chem. 23, 12.
2013: External reviewer for the Peptide Synthesis Facility at the Cancer Research UK London Research Institute
2011: EMBO Practical Course: Methods in Chemical Biology, Heidelberg, Organizer


Honors and Awards:

2016: Miklos Bodanszky Award of the European Peptide Society
2015: Tetrahedron Young Investigator Award in Bioorg. and Med. Chemistry
Since 2014: Investigator of the ERC (starting grant)
2014: Friedmund Neumann Prize of the Schering Foundation
2010–2015: DFG “Emmy Noether Research Group” Leader
2008: Friedrich-Weygand-Price of the Max-Bergmann-Society
2007: AACR-GlaxoSmithKline Scholar-In-Training-Award
2005–2007: Postdoctoral fellowship, German Academic Exchange Service(DAAD)


Selected Publications:

Luján P, Varsano G, Rubio T, Hennrich ML, Sachsenheimer T, Gálvez-Santisteban M, Martín-Belmonte F, Gavin AC, Brügger B, Köhn M. PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position. J Cell Sci. 2016 Nov 1;129(21):4130-4142.  Abstract

Fontanillo M, Zemskov I, Häfner M, Uhrig U, Salvi F, Simon B, Wittmann V, Köhn M. Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1. Angew Chem Int Ed Engl. 2016 Nov 2;55(45):13985-13989.  Abstract

Fahs S, Lujan P, Köhn M. Approaches to Study Phosphatases. ACS Chem Biol. 2016 Nov 18;11(11):2944-2961.  Abstract

Duan G, Li X, Köhn M. The human DEPhOsphorylation database DEPOD: a 2015 update. Nucleic Acids Res. 2015 Jan;43(Database issue):D531-5.  Abstract

Hoeger B, Diether M, Ballester PJ, Köhn M. Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver. Eur J Med Chem. 2014 Dec 17;88:89-100.  Abstract

Pavic K, Rios P, Dzeyk K, Koehler C, Lemke EA, Köhn M. Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity. ACS Chem Biol. 2014 Jul 18;9(7):1451-9.  Abstract

Li X, Wilmanns M, Thornton J, Köhn M. Elucidating human phosphatase-substrate networks. Sci Signal. 2013 May 14;6(275):rs10.  Abstract

Reither G, Chatterjee J, Beullens M, Bollen M, Schultz C, Köhn M. Chemical activators of protein phosphatase-1 induce calcium release inside intact cells. Chem Biol. 2013 Sep 19;20(9):1179-86.  Abstract

Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M, Köhn M. Development of a peptide that selectively activates protein phosphatase-1 in living cells. Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10054-9.  Abstract

Bru M, Kotkar SP, Kar N, Köhn M. Development of a solid phase synthesis strategy for soluble phosphoinositide analogues. Chem Sci. 2012, 3, 1893-1902.  Abstract



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