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Contact
| Lab: | Prof. Maja Köhn |
| Department: | BIOSS Centre for Biological Signalling Studies Institute of Biology III |
| Address: | Schänzlestr. 18 79104 Freiburg |
| Phone: | +49-761 203 67900 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| PhD positions available: | YES |
| Research Area: | Protein Structure and Function |
| Research Interests: | -Elucidation of the functions and molecular mechanisms of the cancer-promoting phosphatase PRL-3 and the ubiquitous phosphatase PP1 -Development of inhibitors and activators for phosphatases |
CV
| Education & Training: | 2002–2005: Dr. rer. nat. in Organic Chemistry, Technical University Dortmund and MPI for Molecular Physiology (supervisor: Prof. H. Waldmann) 1996–2001: Diploma in Chemistry, Christian-Albrechts-University, Kiel, Germany |
| Employment & Experience: | Since 2016: Full Professor (W3) for Integrative Signaling Studies, University of Freiburg 2007–2016: Group leader, European Molecular Biology Laboratory, Heidelberg 2005–2007: Postdoctoral researcher, Harvard University, Cambridge, USA (supervisor: Prof. G. L. Verdine) |
| Scientific Activities: | 2008,10,12,14,16: EMBO conference series: Chemical Biology, Heidelberg, Organizer Since 2016: Editorial Advisory Board of Bioorganic and Medicinal Chemistry Since 2016: Editorial Advisory Board of ACS Chemical Biology 2015: Guest Editor: ‘Chemistry and biology of protein and inositol phosphorylation’, Bioorg. Med. Chem. 23, 12. 2013: External reviewer for the Peptide Synthesis Facility at the Cancer Research UK London Research Institute 2011: EMBO Practical Course: Methods in Chemical Biology, Heidelberg, Organizer |
Honors
| Honors and Awards: | 2016: Miklos Bodanszky Award of the European Peptide Society |
Publications
| Selected Publications: | Luján P, Varsano G, Rubio T, Hennrich ML, Sachsenheimer T, Gálvez-Santisteban M, Martín-Belmonte F, Gavin AC, Brügger B, Köhn M. PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position. J Cell Sci. 2016 Nov 1;129(21):4130-4142. Abstract Fontanillo M, Zemskov I, Häfner M, Uhrig U, Salvi F, Simon B, Wittmann V, Köhn M. Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1. Angew Chem Int Ed Engl. 2016 Nov 2;55(45):13985-13989. Abstract Fahs S, Lujan P, Köhn M. Approaches to Study Phosphatases. ACS Chem Biol. 2016 Nov 18;11(11):2944-2961. Abstract Duan G, Li X, Köhn M. The human DEPhOsphorylation database DEPOD: a 2015 update. Nucleic Acids Res. 2015 Jan;43(Database issue):D531-5. Abstract Hoeger B, Diether M, Ballester PJ, Köhn M. Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver. Eur J Med Chem. 2014 Dec 17;88:89-100. Abstract Pavic K, Rios P, Dzeyk K, Koehler C, Lemke EA, Köhn M. Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity. ACS Chem Biol. 2014 Jul 18;9(7):1451-9. Abstract Li X, Wilmanns M, Thornton J, Köhn M. Elucidating human phosphatase-substrate networks. Sci Signal. 2013 May 14;6(275):rs10. Abstract Reither G, Chatterjee J, Beullens M, Bollen M, Schultz C, Köhn M. Chemical activators of protein phosphatase-1 induce calcium release inside intact cells. Chem Biol. 2013 Sep 19;20(9):1179-86. Abstract Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M, Köhn M. Development of a peptide that selectively activates protein phosphatase-1 in living cells. Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10054-9. Abstract Bru M, Kotkar SP, Kar N, Köhn M. Development of a solid phase synthesis strategy for soluble phosphoinositide analogues. Chem Sci. 2012, 3, 1893-1902. Abstract
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