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Lutz Hein Profile Page
Lutz Hein


Lab: Prof. Lutz Hein
Department: Institute of Experimental and Clinical Pharmacology and Toxicology
Department II
Address: Albertstr. 25
79104 Freiburg
Phone: +49 761 203 5313
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster: Associated
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: - GPCR signaling in the cardiovascular system
- Cell-type specific signaling mechanisms in the heart
- Epigenetic mechanisms of physiological and pathological gene expression
- Cardiovascular pharmacology


Education & Training: 1982-1988: Medical studies, University of Kiel (Germany) and University of California, San Diego (USA)
1988: Medical degree (Dr. med.), University of Kiel, Germany
1999: Habilitation
1999: Specialist (Facharzt) in Pharmacology and Toxicology
2003: Specialist (Facharzt) in Clinical Pharmacology
Employment & Experience: 1988-1991: Postdoc, Pharmacology, University of Kiel, Germany
1991-1995: Postdoc, Cardiovascular Medicine, Stanford University, USA
1995-1996: Clinical Assistant Professor, Cardiovascular Medicine, Stanford University, USA
1996-2002: Group leader, Pharmacology, University of Würzburg, Germany
2002-2004: Professor of Pharmacology, University of Würzburg, Germany
since 2004: Professor and Chair of Pharmacology and Toxicology, University of Freiburg, Germany
Scientific Activities: since 2012: Member of the Leopoldina, German National Academy of Sciences
2011-2016: President, German Pharmacological Society (DGP e.V.)
since 2008: Scientific Advisory Board Member, "Deutsche Stiftung für Herzforschung"
since 2007: Member of the "Arzneimittelkommision der deutschen Ärzteschaft (AKdÄ)"


Honors and Awards:

2001:    Schunk-Award for Medicine, University of Giessen
1999:    New Investigator Award, American Heart Association
1995:    Cardiovascular Medicine Award, Stanford University
1994:    Investigator Award, American Federation for Clinical Research
1991-1993:  Fellow of the American Heart Association
1982-1988:  Fellow of the "Studienstiftung des deutschen Volkes"
1980:    Award in Biology "Jugend forscht"
1981:    European Philips Contest Award, Brüssel, Belgium
1979:    European Philips Contest Award, Oslo, Norway


Selected Publications:

Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A. MOF Acetyl Transferase Regulates Transcription  and Respiration in Mitochondria. Cell. 2016 Oct 20;167(3):722-738.e23.  Abstract

Lother A, Hein L. Pharmacology of heart failure: From basic science to novel therapies. Pharmacol Ther. 2016 Oct;166:136-49.  Abstract

Kranzhöfer DK, Gilsbach R, Grüning BA, Backofen R, Nührenberg TG, Hein L. 5'-Hydroxymethylcytosine Precedes Loss of CpG Methylation in Enhancers and Genes Undergoing Activation in Cardiomyocyte Maturation. PLoS One. 2016 Nov 16;11(11):e0166575.  Abstract

Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K. Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nat Med. 2015 Nov;21(11):1298-306.  Abstract

Mayer SC, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Krüger M, Thum T, Doenst T, Stoll M, Hein L. Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure. Circ Res. 2015 Sep 11;117(7):622-33.  Abstract

Preissl S, Schwaderer M, Raulf A, Hesse M, Grüning BA, Köbele C, Backofen R, Fleischmann BK, Hein L, Gilsbach R. Deciphering the Epigenetic Code of Cardiac Myocyte Transcription. Circ Res. 2015 Aug 14;117(5):413-23.  Abstract

Nührenberg TG, Hammann N, Schnick T, Preißl S, Witten A, Stoll M, Gilsbach R, Neumann FJ, Hein L. Cardiac Myocyte De Novo DNA Methyltransferases 3a/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice. PLoS One. 2015 Jun 22;10(6):e0131019.  Abstract

Gilsbach R, Preissl S, Grüning BA, Schnick T, Burger L, Benes V, Würch A, Bönisch U, Günther S, Backofen R, Fleischmann BK, Schübeler D, Hein L. Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease. Nat Commun. 2014 Oct 22;5:5288.  Abstract

Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Lorkowski S, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, Kotchen TA, Kaldunski M, Nüsing R, Szabo B, Jacob HJ, Cowley AW Jr, Biel M, Stoll M, Lohse MJ, Broeckel U, Hein L. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest. 2009 Dec;119(12):3597-3612.  Abstract

Boettger T, Beetz N, Kostin S, Schneider J, Krüger M, Hein L, Braun T. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest. 2009 Sep;119(9):2634-47.  Abstract

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