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Contact
| Lab: | Prof. Lutz Hein |
| Department: | Institute of Experimental and Clinical Pharmacology and Toxicology Department II |
| Address: | Albertstr. 25 79104 Freiburg |
| Phone: | +49 761 203 5313 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | portal.uni-freiburg.de/pharmakologie/ii |
| BIOSS Excellence Cluster: | Associated |
| PhD positions available: | NO |
| Research Area: | Molecular Medicine |
| Research Interests: | - GPCR signaling in the cardiovascular system - Cell-type specific signaling mechanisms in the heart - Epigenetic mechanisms of physiological and pathological gene expression - Cardiovascular pharmacology |
CV
| Education & Training: | 1982-1988: Medical studies, University of Kiel (Germany) and University of California, San Diego (USA) 1988: Medical degree (Dr. med.), University of Kiel, Germany 1999: Habilitation 1999: Specialist (Facharzt) in Pharmacology and Toxicology 2003: Specialist (Facharzt) in Clinical Pharmacology |
| Employment & Experience: | 1988-1991: Postdoc, Pharmacology, University of Kiel, Germany 1991-1995: Postdoc, Cardiovascular Medicine, Stanford University, USA 1995-1996: Clinical Assistant Professor, Cardiovascular Medicine, Stanford University, USA 1996-2002: Group leader, Pharmacology, University of Würzburg, Germany 2002-2004: Professor of Pharmacology, University of Würzburg, Germany since 2004: Professor and Chair of Pharmacology and Toxicology, University of Freiburg, Germany |
| Scientific Activities: | since 2012: Member of the Leopoldina, German National Academy of Sciences 2011-2016: President, German Pharmacological Society (DGP e.V.) since 2008: Scientific Advisory Board Member, "Deutsche Stiftung für Herzforschung" since 2007: Member of the "Arzneimittelkommision der deutschen Ärzteschaft (AKdÄ)" |
Honors
| Honors and Awards: | 2001: Schunk-Award for Medicine, University of Giessen |
Publications
| Selected Publications: | Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A. MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria. Cell. 2016 Oct 20;167(3):722-738.e23. Abstract Lother A, Hein L. Pharmacology of heart failure: From basic science to novel therapies. Pharmacol Ther. 2016 Oct;166:136-49. Abstract Kranzhöfer DK, Gilsbach R, Grüning BA, Backofen R, Nührenberg TG, Hein L. 5'-Hydroxymethylcytosine Precedes Loss of CpG Methylation in Enhancers and Genes Undergoing Activation in Cardiomyocyte Maturation. PLoS One. 2016 Nov 16;11(11):e0166575. Abstract Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, Deiss K, Denzinger S, Herrmann S, Wettwer E, Weidendorfer M, Becker D, Schäfer F, Wagner N, Ergün S, Schmitt JP, Katus HA, Weidemann F, Ravens U, Maack C, Hein L, Ertl G, Müller OJ, Maier LS, Lohse MJ, Lorenz K. Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nat Med. 2015 Nov;21(11):1298-306. Abstract Mayer SC, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Rühle F, Schrepper A, Schwarzer M, Heilmann C, Bönisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Krüger M, Thum T, Doenst T, Stoll M, Hein L. Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure. Circ Res. 2015 Sep 11;117(7):622-33. Abstract Preissl S, Schwaderer M, Raulf A, Hesse M, Grüning BA, Köbele C, Backofen R, Fleischmann BK, Hein L, Gilsbach R. Deciphering the Epigenetic Code of Cardiac Myocyte Transcription. Circ Res. 2015 Aug 14;117(5):413-23. Abstract Nührenberg TG, Hammann N, Schnick T, Preißl S, Witten A, Stoll M, Gilsbach R, Neumann FJ, Hein L. Cardiac Myocyte De Novo DNA Methyltransferases 3a/3b Are Dispensable for Cardiac Function and Remodeling after Chronic Pressure Overload in Mice. PLoS One. 2015 Jun 22;10(6):e0131019. Abstract Gilsbach R, Preissl S, Grüning BA, Schnick T, Burger L, Benes V, Würch A, Bönisch U, Günther S, Backofen R, Fleischmann BK, Schübeler D, Hein L. Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease. Nat Commun. 2014 Oct 22;5:5288. Abstract Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Lorkowski S, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, Kotchen TA, Kaldunski M, Nüsing R, Szabo B, Jacob HJ, Cowley AW Jr, Biel M, Stoll M, Lohse MJ, Broeckel U, Hein L. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest. 2009 Dec;119(12):3597-3612. Abstract Boettger T, Beetz N, Kostin S, Schneider J, Krüger M, Hein L, Braun T. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest. 2009 Sep;119(9):2634-47. Abstract |
SGBM PhD students
| SGBM PhD students: | Terrence Tigney (since May 2020) |
