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Gabriele Niedermann Profile Page
Gabriele Niedermann


Lab: Prof. Dr. Gabriele Niedermann
Department: Center for Diagnostic and Therapeutic Radiology
Department of Radiation Oncology
University Medical Center
Address: Robert-Koch-Str. 3
D-79106 Freiburg
Phone: +49 761 270 95140
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: Tumor Immunology, Tumor Immunotherapy, Radiobiology, Molecular Imaging


Education & Training: 2000: Habilitation in Experimental Medicine, University of Freiburg
1991: Dissertation in Medicine, University of Halle/Wittenberg
1982–1988: Medical studies in Halle/Saale
Employment & Experience: since 2005: Apl. Professor, Head of the Section of Molecular Radiation Oncology, Department of Radiation Oncology, University Medical Center – Freiburg
1996–2004: Principal Investigator, Max-Planck Institute of Immunobiology, Freiburg
1992–1995: Postdoctorate, Max-Planck Institute of Immunobiology, Freiburg
1988–1991: Scientist, Department of Medical Biochemistry, Halle/Saale


Honors and Awards:

2016: “Best of ASTRO” in the category Radiobiology at the Annual Meeting of the American Society for Radiation Oncology (ASTRO) and the “Best of ASTRO” Meeting
2015: “Highest Scoring Abstract” in the category Radiobiology at the Annual Meeting of the European Society for Radiation Oncology (ESTRO)
2014: Scientific Highlight at the Annual Retreat of the German Consortium for Translational Cancer Research (DKTK)
2005: Hector Research Award by the H.W. & J. Hector Foundation
2003: Langen Research Prize by the Paul-Ehrlich Institute and the City of Langen
1997: James-Heineman Research Award by the Minna-James-Heineman Foundation


Selected Publications:

Hettich M, Braun F, Bartholomä MD, Schirmbeck R, Niedermann G. High-Resolution PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers. Theranostics. 2016 Jun 18;6(10):1629-40.  Abstract

Hettich M, Lahoti J, Prasad S, Niedermann G. Checkpoint Antibodies but not T Cell-Recruiting Diabodies Effectively Synergize with TIL-Inducing γ-Irradiation. Cancer Res. 2016 Aug 15;76(16):4673-83.  Abstract

Firat E, Niedermann G. FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition. Oncotarget. 2016 Aug 23;7(34):54883-54896.  Abstract

Jing H, Weidensteiner C, Reichardt W, Gaedicke S, Zhu X, Grosu AL, Kobayashi H, Niedermann G. Imaging and Selective Elimination of Glioblastoma Stem Cells with Theranostic Near-Infrared-Labeled CD133-Specific Antibodies. Theranostics. 2016 Apr 12;6(6):862-74.  Abstract

Zhu X, Prasad S, Gaedicke S, Hettich M, Firat E, Niedermann G. Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57. Oncotarget. 2015 Jan 1;6(1):171-84.  Abstract

Prasad S, Gaedicke S, Machein M, Mittler G, Braun F, Hettich M, Firat E, Klingner K, Schüler J, Wider D, Wäsch RM, Herold-Mende C, Elsässer-Beile U, Niedermann G. Effective Eradication of Glioblastoma Stem Cells by Local Application of an AC133/CD133-Specific T-cell-Engaging Antibody and CD8 T Cells.  Cancer Res. 2015 Jun 1;75(11):2166-76.  Abstract

Gaedicke S, Braun F, Prasad S, Machein M, Firat E, Hettich M, Gudihal R, Zhu X, Klingner K, Schüler J, Herold-Mende CC, Grosu AL, Behe M, Weber W, Mäcke H, Niedermann G. Noninvasive positron emission tomography and fluorescence imaging of CD133+ tumor stem cells. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E692-701.  Abstract

Saveanu L, Carroll O, Weimershaus M, Guermonprez P, Firat E, Lindo V, Greer F, Davoust J, Kratzer R, Keller SR, Niedermann G, van Endert P. IRAP identifies an endosomal compartment required for MHC class I cross-presentation. Science. 2009 Jul 10;325(5937):213-7.  Abstract

Huai J, Firat E, Nil A, Million D, Gaedicke S, Kanzler B, Freudenberg M, van Endert P, Kohler G, Pahl HL, Aichele P, Eichmann K, Niedermann G. Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5177-82.  Abstract

Saveanu L, Carroll O, Lindo V, Del Val M, Lopez D, Lepelletier Y, Greer F, Schomburg L, Fruci D, Niedermann G, van Endert PM. Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat Immunol. 2005 Jul;6(7):689-97.  Abstract

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