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Nadine Wössner

Contact

PhD Lab:

Susana Minguet

Department: Molecular Immunology, Institute of Biology III
CIBSS (Centre for Integrative Biological Signalling Studies)
Address: Signalhaus
Schänzlestraße 18
79108 Freiburg
Phone: +49 761 203 67525
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.bioss.uni-freiburg.de/groups/minguet-group/home/
Track: CIBSS Track
Research Area: Immunology and Virology

Curriculum Vitae

Country: Germany
Education/Training: BSc in Biology, University of Freiburg (graduated 2016)
MSc in Biology, University of Freiburg (graduated 2019)
Start of PhD Thesis: July 2019
Subject of Thesis: Aligning dynamic TCR assembly with optimal anti-tumour Responses
Research Interests: Clinical and molecular Immunology
Research Techniques: Cell Culture, Flow Cytometry, Western Blotting, PCR, Pull-down and Immunoprecipitation Assays, Proximity Ligation Assay, Molecular Cloning, Transfections and lentiviral Transductions, Mouse Models

Publications

Publications:

Schultz A, Schnurra M, El-Bizri A, Woessner NM, Hartmann S, Roland Hartig R, Minguet S, Schraven B and Simeoni L. A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling. Cells (2022) LINK

Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K, Woessner NM, Lalioti M, Velasco-Hernandez T, Sikora K, Wäsch R, Lehnertz B, Sauvageau G, Manke T, Menendez P, Walter SG, Minguet S, Laurenti E, Günther S, Grün D & Cabezas-Wallscheid N. Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells. Nat Cell Biol (2022) Jun 20. doi: 10.1038/s41556-022-00931-x. Abstract

Kästle M, Merten C, Hartig R, Kaehne T, Liaunardy-Jopeace A, Woessner NM, Schamel WW, James J, Minguet S, Simeoni L, Schraven B. Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions. Cell Commun Signal. (2020) 18(1):183. LINK

Hartl FA, Beck-Garcìa E, Woessner NM, Flachsmann LJ, Velasco Cardenas RMH, Brandl SM, Taromi S, Fiala GJ, Morath A, Mishra P, Yousefi OS, Zimmermann J, Hoefflin N, Köhn M, Wöhrl BM, Zeiser R, Schweimer K, Günther S, Schamel WW & Minguet S. Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function. Nat Immunol (2020). https://doi.org/10.1038/s41590-020-0732-3. LINK

Thesis Committee

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