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Franziska Schneider-Warme Profile Page
Franziska Schneider-Warme


Lab: Dr. Franziska Schneider-Warme
Department: Institute for Experimental Cardiovascular Medicine
Cardiac Optogenetics section
University of Freiburg
Address: Elsässer Str. 2Q
79110 Freiburg
Phone: +49 761 270 63954
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: • Design and implementation of new optogenetic tools for modulating the activity of excitable cells and tissues
• Development of optogenetic approaches for functionally dissecting electrical interactions between cardiac cell populations, with a current focus on cardiomyocytes, fibroblasts and resident immune cells
• Electrophysiological characterization of cardiac non-myocytes
• 3D reconstruction of cellular networks in healthy and diseased hearts


Education & Training: 2010-2014: Dr. rer. nat. in Biophysics, Humboldt-Universität zu Berlin, Germany
2004-2009: Diploma in Biophysics (equivalent to MSc), Humboldt-Universität zu Berlin, Germany
2006-2007: Molecular and Cellular Biochemistry course, Université de Bordeaux, France
Employment & Experience: Since 2019: Emmy-Noether research group leader, Institute for Experimental Cardiovascular Medicine, UHZ Freiburg · Bad Krozingen
Since 2016: Head of Cardiac Optogenetics Section, Institute for Experimental Cardiovascular Medicine, UHZ Freiburg · Bad Krozingen
2015: Postdoctoral research fellow, National Heart and Lung Institute, Imperial College London, UK
2014: Postdoctoral scientist, Humboldt-Universität zu Berlin, Germany


Honors and Awards:

Since 2021: Elected member of the nucleus of the working group “Cellular Electrophysiology” of the German Cardiac Society (DGK)
Since 2021: Associate investigator within the excellence cluster “Centre for Integrative Biological Signalling Studies” (CIBSS)
Since 2020: Elected member of the steering committee of DFG Collaborative Research Centre SFB 1425 “Heterocellular Nature of Cardiac Lesions”
2019-2021: Selected member of CORA mentoring programme, University of Freiburg
2018: Emmy-Noether grant and fellowship
Since 2016: Elected member of the steering committee of DFG Scientific Priority Programme SPP 1926 “Next Generation Optogenetics”
2014: Humboldt-prize for excellent dissertation
2010: Humboldt-prize for excellent diploma thesis
2006-2007: Erasmus stipend


Selected Publications:

Simon-Chica A, Fernández MC, Wülfers EM, Lother A, Hilgendorf I, Seemann G, Ravens U, Kohl P, Schneider-Warme F. Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels. Cardiovasc Res. 2021 Apr 6:cvab126.  Abstract

Fernández MC, Kopton RA, Simon-Chica A, Madl J, Hilgendorf I, Zgierski-Johnston CM, Schneider-Warme F. Channelrhodopsins for Cell-Type Specific Illumination of Cardiac Electrophysiology. Methods Mol Biol. 2021;2191:287-307.  Abstract

Kopton RA, Baillie JS, Rafferty SA, Moss R, Zgierski-Johnston CM, Prykhozhij SV, Stoyek MR, Smith FM, Kohl P, Quinn TA, Schneider-Warme F. Cardiac Electrophysiological Effects of Light-Activated Chloride Channels. Front Physiol. 2018 Dec 17;9:1806.  Abstract

Bernal Sierra YA, Rost BR, Pofahl M, Fernandes AM, Kopton RA, Moser S, Holtkamp D, Masala N, Beed P, Tukker JJ, Oldani S, Bönigk W, Kohl P, Baier H, Schneider-Warme F, Hegemann P, Beck H, Seifert R, Schmitz D. Potassium channel-based optogenetic silencing. Nat Commun. 2018 Nov 5;9(1):4611.  Abstract

Rost BR*, Schneider-Warme F*, Schmitz D, Hegemann P. Optogenetic Tools for Subcellular Applications in Neuroscience. Neuron. 2017 Nov 1;96(3):572-603. *Equal contribution.  Abstract

Rost BR, Schneider F, Grauel MK, Wozny C, Bentz C, Blessing A, Rosenmund T, Jentsch TJ, Schmitz D, Hegemann P, Rosenmund C. Optogenetic acidification of synaptic vesicles and lysosomes. Nat Neurosci. 2015 Dec;18(12):1845-1852.  Abstract

Schneider F, Grimm C, Hegemann P. Biophysics of Channelrhodopsin. Annu Rev Biophys. 2015;44:167-86.  Abstract

Wietek J, Wiegert JS, Adeishvili N, Schneider F, Watanabe H, Tsunoda SP, Vogt A, Elstner M, Oertner TG, Hegemann P. Conversion of channelrhodopsin into a light-gated chloride channel. Science. 2014 Apr 25;344(6182):409-12.  Abstract

Schneider F, Gradmann D, Hegemann P. Ion selectivity and competition in channelrhodopsins. Biophys J. 2013 Jul 2;105(1):91-100.  Abstract

Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 2011 Jul 27;477(7363):171-8.  Abstract

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