Eva Rog-Zielinska

Eva Rog-Zielinska Profile Page

Contact

Lab:	Dr. Eva Rog-Zielinska
Department:	Institute for Experimental Cardiovascular Medicine Faculty of Medicine, University of Freiburg
Address:	Elsässerstraβe 2Q, 79110 Freiburg
Phone:	+49 761 270 63954
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.uniklinik-freiburg.de/experimentelle-kardiovaskulaere-medizin/team/eva-rog-zielinska-phd.html
PhD positions available:	YES
Research Area:	Molecular Medicine
Research Interests:	- Nano-to-micro scale investigation of the impact of contractions on structure and function (ion homostasis, metabolism) of cardiac subcellular domains: T-tubules, mitochondria, sarcoplasmic reticulum, nucleus, cytoskeleton, plasma membrane; using methods such as 3D electron microscopy, live-cell advanced light microscopy, genetic vector design and manipulation, pharmacological testing. - Interactions between myocytes and non-myocytes (fibroblasts, macrophages) in the heart, role of tunneling nanotubes in inter-cellular communication; using methods such as 3D electron microscopy, live-cell super resolution light microscopy, genetic vector design and manipulation, advanced cell and tissue culture, environmental manipulation (hypoxia, matrix stiffness). - Artificial intelligence-assisted image analysis method development

CV

Education & Training:

2009-2013: PhD Cardiovascular Science, University of Edinburgh, UK
2008-2009: MSc Cardiovascular Science, University of Edinburgh, UK
2006: MSc Biomedical Sciences, Nicolaus Copernicus University, Toruń, Poland
2003-2006: BSc Biotechnology, Nicolaus Copernicus University, Toruń, Poland

Employment & Experience:

08/2018: Emmy Noether (DFG) Independent Junior Research Group Leader
09/2017: Section Head (4D Imaging), Institute for Experimental Cardiovascular Medicine, Freiburg
02/2015-09/2017: BHF Immediate Post-doctoral Fellow, Imperial College London, UK
09/2013-02/2015: Post-doctoral Research Associate, Imperial College London, UK
06/2013-09/2013: BHF Centre for Research Excellence Postdoctoral Research Fellow, University of Edinburgh, UK

Publications

Selected Publications:

Rog-Zielinska EA, Scardigli M, Peyronnet R, Zgierski-Johnston CM, Greiner J, Madl J, O'Toole ET, Morphew M, Hoenger A, Sacconi L, Kohl P. Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange. Circ Res. 2021 Jan 22;128(2):203-215. Abstract

Rog-Zielinska EA, Moss R, Kaltenbacher W, Greiner J, Verkade P, Seemann G, Kohl P, Cannell MB. Nano-scale morphology of cardiomyocyte t-tubule/sarcoplasmic reticulum junctions revealed by ultra-rapid high-pressure freezing and electron tomography. J Mol Cell Cardiol. 2021 Apr;153:86-92. Abstract

MacDonald EA, Madl J, Greiner J, Ramadan AF, Wells SM, Torrente AG, Kohl P, Rog-Zielinska EA, Quinn TA. Sinoatrial Node Structure, Mechanics, Electrophysiology and the Chronotropic Response to Stretch in Rabbit and Mouse. Front Physiol. 2020 Jul 22;11:809. Abstract

Rog-Zielinska EA, O'Toole ET, Hoenger A, Kohl P. Mitochondrial Deformation During the Cardiac Mechanical Cycle. Anat Rec (Hoboken). 2019 Jan;302(1):146-152. Abstract

Rog-Zielinska EA, Kong CHT, Zgierski-Johnston CM, Verkade P, Mantell J, Cannell MB, Kohl P. Species differences in the morphology of transverse tubule openings in cardiomyocytes. Europace. 2018 Nov 1;20(suppl_3):iii120-iii124. Abstract

Kong CHT*, Rog-Zielinska EA*, Kohl P, Orchard CH, Cannell MB. Solute movement in the t-tubule system of rabbit and mouse cardiomyocytes. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7073-E7080. *Equal contribution. Abstract

Scardigli M, Crocini C, Ferrantini C, Gabbrielli T, Silvestri L, Coppini R, Tesi C, Rog-Zielinska EA, Kohl P, Cerbai E, Poggesi C, Pavone FS, Sacconi L. Quantitative assessment of passive electrical properties of the cardiac T-tubular system by FRAP microscopy. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5737-5742. Abstract

Quinn TA*, Camelliti P*, Rog-Zielinska EA*, Siedlecka U, Poggioli T, O'Toole ET, Knöpfel T, Kohl P. Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14852-14857. *Equal contribution. Abstract

Brandenburg S, Kohl T, Williams GS, Gusev K, Wagner E, Rog-Zielinska EA, Hebisch E, Dura M, Didié M, Gotthardt M, Nikolaev VO, Hasenfuss G, Kohl P, Ward CW, Lederer WJ, Lehnart SE. Axial tubule junctions control rapid calcium signaling in atria. J Clin Invest. 2016 Oct 3;126(10):3999-4015. Abstract

Rog-Zielinska EA, Johnston CM, O'Toole ET, Morphew M, Hoenger A, Kohl P. Electron tomography of rabbit cardiomyocyte three-dimensional ultrastructure. Prog Biophys Mol Biol. 2016 Jul;121(2):77-84. Abstract

SGBM PhD students

SGBM PhD students:

Sofia Oros Rodrigo

Arash Felekary (since April 2021)

Stephanie Schmid (since November 2020)