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Eva Rog-Zielinska

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Lab: Dr. Eva Rog-Zielinska
Department: Institute for Experimental Cardiovascular Medicine
Faculty of Medicine, University of Freiburg
Address: Elsässerstraβe 2Q,
79110 Freiburg
Phone: +49 761 270 63954
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Research Area: Molecular Medicine
Research Interests: - Structural and functional properties of atrial and ventricular T-tubules
- Nano-to-micro scale investigation of the impact of mechanical activity on cardiac T-tubular system and other subcellular domains (mitochondria, sarcoplasmic reticulum, nucleus, cytoskeleton, plasma membrane)
- Interactions between myocytes and non-myocytes in the heart (structural and functional)
- Structural remodelling during heart disease (e.g. hypertrophy, fibrosis, inflammatory processes) and reverse remodelling

CV

Education & Training: 2009-2013: PhD Cardiovascular Science, University of Edinburgh, UK
2008-2009: MSc Cardiovascular Science, University of Edinburgh, UK
2006: MSc Biomedical Sciences, Nicolaus Copernicus University, Toruń, Poland
2003-2006: BSc Biotechnology, Nicolaus Copernicus University, Toruń, Poland
Employment & Experience: 08/2018: Emmy Noether (DFG) Independent Junior Research Group Leader
09/2017: Section Head (4D Imaging), Institute for Experimental Cardiovascular Medicine, Freiburg
02/2015-09/2017: BHF Immediate Post-doctoral Fellow, Imperial College London, UK
09/2013-02/2015: Post-doctoral Research Associate, Imperial College London, UK
06/2013-09/2013: BHF Centre for Research Excellence Postdoctoral Research Fellow, University of Edinburgh, UK

Publications

Selected Publications:

Rog-Zielinska EA, O'Toole ET, Hoenger A, Kohl P. Mitochondrial Deformation During the Cardiac Mechanical Cycle. Anat Rec (Hoboken). 2019 Jan;302(1):146-152.  Abstract

Rog-Zielinska EA, Kong CHT, Zgierski-Johnston CM, Verkade P, Mantell J, Cannell MB, Kohl P. Species differences in the morphology of transverse tubule openings in cardiomyocytes. Europace. 2018 Nov 1;20(suppl_3):iii120-iii124.  Abstract

Kong CHT*, Rog-Zielinska EA*, Kohl P, Orchard CH, Cannell MB. Solute movement in the t-tubule system of rabbit and mouse cardiomyocytes. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7073-E7080. *Equal contribution.  Abstract

Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. Circ Res. 2018 Jan 5;122(1):58-73.  Abstract

Burton RAB*, Rog-Zielinska EA*, Corbett AD, Peyronnet R, Bodi I, Fink M, Sheldon J, Hoenger A, Calaghan SC, Bub G, Kohl P. Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation. Biophys J. 2017 Sep 5;113(5):1047-1059. *Equal contribution.   Abstract

Scardigli M, Crocini C, Ferrantini C, Gabbrielli T, Silvestri L, Coppini R, Tesi C, Rog-Zielinska EA, Kohl P, Cerbai E, Poggesi C, Pavone FS, Sacconi L. Quantitative assessment of passive electrical properties of the cardiac T-tubular system by FRAP microscopy. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5737-5742.  Abstract

Aston D, Capel RA, Ford KL, Christian HC, Mirams GR, Rog-Zielinska EA, Kohl P, Galione A, Burton RA, Terrar DA. High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart. Sci Rep. 2017 Jan 17;7:40620.  Abstract

Quinn TA*, Camelliti P*, Rog-Zielinska EA*, Siedlecka U, Poggioli T, O'Toole ET, Knöpfel T, Kohl P. Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14852-14857. *Equal contribution.  Abstract

Brandenburg S, Kohl T, Williams GS, Gusev K, Wagner E, Rog-Zielinska EA, Hebisch E, Dura M, Didié M, Gotthardt M, Nikolaev VO, Hasenfuss G, Kohl P, Ward CW, Lederer WJ, Lehnart SE. Axial tubule junctions control rapid calcium signaling in atria. J Clin Invest. 2016 Oct 3;126(10):3999-4015.  Abstract

Rog-Zielinska EA, Johnston CM, O'Toole ET, Morphew M, Hoenger A, Kohl P. Electron tomography of rabbit cardiomyocyte three-dimensional ultrastructure. Prog Biophys Mol Biol. 2016 Jul;121(2):77-84.  Abstract

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