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Robert Grosse Profile Page
Robert Grosse


Lab: Prof. Dr. Robert Grosse
Department: Institute for Clinical and Experimental Pharmacology and Toxicology
Department I
Address: Albertstr. 25
79104 Freiburg
Phone: +49 761 203 5301
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
PhD positions available: YES
Research Area: Synthetic Biology and Signalling
Research Interests: -signal regulation of the actin cytoskeleton
-nuclear actin assembly and chromatin dynamics in signaling and mitosis
-invasive cancer cell migration
-optogenetic control of actin regulators
-high resolution live cell imaging


Education & Training: 2009: Habilitation, Pharmacology and Toxicology, Medical Faculty, University of Heidelberg
2006: Medical specialization (Facharzt) in Pharmacology and Toxicology, University of Heidelberg
1999: Full medical license (Approbation zum Arzt), Free University Berlin
1999: Dissertation (summa cum laude), Free University Berlin
1997: Graduation from Medical Faculty, Free University Berlin
1993–1997: Study of Medicine, Free University Berlin, Germany (Intern at St. Mary’s Hospital, Imperial College, London, UK)
1990–1992: Study of Medicine, University of Halle-Wittenberg, Germany
Employment & Experience: 2019-present: Full professor (W3) and director of Division I, Institute of Experimental and Clinical Pharmacology, Medical Faculty, University of Freiburg
2009-2018: Full professor (W3) and director of the Institute of Pharmacology, Medical Faculty, University of Marburg
2004-2009: Principal Investigator (Emmy Noether Program), Institute of Pharmacology, University of Heidelberg
2000-2003: Post-doc, Lincoln’s Inn Fields Laboratories, London Research Institute London, UK
1999-2000: Physician (AiP), Institute of Pharmacology, Free University Berlin
1992-1993: Research assistant, Georgetown University Medical Center, Washington DC


Honors and Awards:

2016: Human Frontiers Science Program grant (senior applicant and lead investigator)
2013: Offer for full professor and director of the Institute of Pharmacology and Toxicology, TU Dresden (declined)
2013: Binder-Innovation prize, German Society of Cell Biology
2008: Joachim Siebeneicher research prize of the Medical Faculty, University of Heidelberg
2008: C.H.S. Foundation group leader fellowship
2004: Emmy Noether Program investigator (1.1.2004-31.12.2008)
2001: EMBO long-term postdoctoral fellowship
2000: ICRF postdoctoral fellowship
1996: Marius-Tausk-Researchprize, German Society of Endocrinology


Selected Publications:

Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz EM, Tsopoulidis N, Fackler OT, Schwan C, Grosse R. GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics. Nat Commun. 2019 Nov 21;10(1):5271.  Abstract

Tsopoulidis N, Kaw S, Laketa V, Kutscheidt S, Baarlink C, Stolp B, Grosse R, Fackler OT. T cell receptor-triggered nuclear actin network formation drives CD4(+) T cell effector functions. Sci Immunol. 2019 Jan 4;4(31).  Abstract

Plessner M, Knerr J, Grosse R. Centrosomal Actin Assembly Is Required for Proper Mitotic Spindle Formation and Chromosome Congression. iScience. 2019 May 31;15:274-281.  Abstract

Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R. A transient pool of nuclear F-actin at mitotic exit controls chromatin organization. Nat Cell Biol. 2017 Dec;19(12):1389-1399.  Abstract

Hinojosa LS, Holst M, Baarlink C, Grosse R. MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion. J Cell Biol. 2017 Oct 2;216(10):3087-3095.  Abstract

Grikscheit K, Frank T, Wang Y, Grosse R. Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. J Cell Biol. 2015 May 11;209(3):367-76.  Abstract

Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R. Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα. Dev Cell. 2015 Aug 24;34(4):475-83.  Abstract

Purvanov V, Holst M, Khan J, Baarlink C, Grosse R. G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion. Elife. 2014 Jun 20;3.  Abstract

Baarlink C, Wang H, Grosse R. Nuclear actin network assembly by formins regulates the SRF coactivator MAL. Science. 2013 May 17;340(6134):864-7.  Abstract

Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol. 2009 May;11(5):557-68.  Abstract

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