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Nora Vögtle

Contact

Lab: Dr. Nora Vögtle
Department: Institute of Biochemistry and Molecular Biology
Address: Stefan-Meier-Str. 17,
79104 Freiburg
Phone: +49 761 203 5270
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.voegtlelab.org
PhD positions available: YES
Research Area: Protein Structure and Function
Research Interests: Our group wants to understand the role of mitochondrial proteases in the maintenance of the mitochondrial proteome. We use yeast, mammalian and patient cells to investigate the pathophysiological consequences of dysfunctions in these proteases that result in severe neurodegenerative diseases and cardiomyopathies.

CV

Education & Training: 2007-2011: PhD thesis, University of Freiburg, Lab of Chris Meisinger
2002-2007: Diploma in Molecular Medicine, University of Freiburg
Employment & Experience: since 2016: Emmy-Noether group leader, University of Freiburg
2011-2016: Postdoc, University of Freiburg, Lab of Chris Meisinger
2010-2011: Research Internship, La Trobe University, Melbourne, Australia, Lab of Mike Ryan

Honors

Honors and Awards:

2016: AcademiaNet member (nominated by the DFG)
2016: Emmy-Noether grant of the DFG
2014: EMBO short-term fellowship
2014: Elite postdoc fellowship of the Baden-Württemberg Stiftung

Publications

Selected Publications:

Poveda-Huertes D, Matic S, Marada A, Habernig L, Licheva M, Myketin L, Gilsbach R, Tosal-Castano S, Papinski D, Mulica P, Kretz O, Kücükköse C, Taskin AA, Hein L, Kraft C, Büttner S, Meisinger C, Vögtle FN. An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates. Mol Cell. 2019 Oct 14.  Abstract

Vögtle FN, Brändl B, Larson A, Pendziwiat M, Friederich MW, White SM, Basinger A, Kücükköse C, Muhle H, Jähn JA, Keminer O, Helbig KL, Delto CF, Myketin L, Mossmann D, Burger N, Miyake N, Burnett A, van Baalen A, Lovell MA, Matsumoto N, Walsh M, Yu HC, Shinde DN, Stephani U, Van Hove JLK, Müller FJ, Helbig I. Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood. Am J Hum Genet. 2018 Apr 5;102(4):557-573.  Abstract

Vögtle FN, Burkhart JM, Gonczarowska-Jorge H, Kücükköse C, Taskin AA, Kopczynski D, Ahrends R, Mossmann D, Sickmann A, Zahedi RP, Meisinger C. Landscape of submitochondrial protein distribution. Nat Commun. 2017 Aug 18;8(1):290.  Abstract

Taskin AA, Kücükköse C, Burger N, Mossmann D, Meisinger C, Vögtle FN. The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing. Mol Biol Cell. 2017 Apr 15;28(8):997-1002.  Abstract

Eldomery MK, Akdemir ZC, Vögtle FN, Charng WL, Mulica P, Rosenfeld JA, Gambin T, Gu S, Burrage LC, Al Shamsi A, Penney S, Jhangiani SN, Zimmerman HH, Muzny DM, Wang X, Tang J, Medikonda R, Ramachandran PV, Wong LJ, Boerwinkle E, Gibbs RA, Eng CM, Lalani SR, Hertecant J, Rodenburg RJ, Abdul-Rahman OA, Yang Y, Xia F, Wang MC, Lupski JR, Meisinger C, Sutton VR. MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death. Genome Med. 2016 Nov 1;8(1):106.  Abstract

Vögtle FN, Keller M, Taskin AA, Horvath SE, Guan XL, Prinz C, Opalińska M, Zorzin C, van der Laan M, Wenk MR, Schubert R, Wiedemann N, Holzer M, Meisinger C. The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1. J Cell Biol. 2015 Sep 14;210(6):951-60.  Abstract

Burkhart JM, Taskin AA, Zahedi RP, Vögtle FN. Quantitative Profiling for Substrates of the Mitochondrial Presequence Processing Protease Reveals a Set of Nonsubstrate Proteins Increased upon Proteotoxic Stress. J Proteome Res. 2015 Nov 6;14(11):4550-63.  Abstract

Mossmann D, Vögtle FN, Taskin AA, Teixeira PF, Ring J, Burkhart JM, Burger N, Pinho CM, Tadic J, Loreth D, Graff C, Metzger F, Sickmann A, Kretz O, Wiedemann N, Zahedi RP, Madeo F, Glaser E, Meisinger C. Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab. 2014 Oct 7;20(4):662-9.  Abstract

Vögtle FN, Burkhart JM, Rao S, Gerbeth C, Hinrichs J, Martinou JC, Chacinska A, Sickmann A, Zahedi RP, Meisinger C. Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics. 2012 Dec;11(12):1840-52.  Abstract

Vögtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C. Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell. 2009 Oct 16;139(2):428-39.  Abstract

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