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Dennis Wolf

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Lab: PD Dr. Dennis Wolf
Department: Cardiology and Angiology I
'Vascular Immunology' Lab
University Heart Center Freiburg-Bad Krozingen
Address: Hugstetterstrasse 55
79106 Freiburg
Phone: +49 761 270 70380
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.herzzentrum.de/kliniken-fachbereiche/klinik-fuer-kardiologie-und-angiologie-i/grundlagenforschung/vascular-immunology/
PhD positions available: YES
Research Area: Molecular Medicine

CV

Education & Training: 2007: Medical School, University of Freiburg, Germany / University of Queensland, Brisbane, Australia / National University of Singapore, Singapore / Lachen Hospital, University of Zurich, Switzerland
2012: MD-degree Albert-Ludwigs-Universität Freiburg
2019: Habilitation
Employment & Experience: Since 01/19: Head of the Clinical Study Section, Cardiology and Angiology I, University Heart Centre / Medical Centre, University of Freiburg, Germany
Since 12/18: Attending Physician (‘Oberarzt’), Cardiology and Angiology I, University Heart Centre / Medical Centre, University of Freiburg, Germany
Since 07/17: Principle Investigator “Vascular Immunology” laboratory, Cardiology and Angiology I, University Heart Centre / Medical Centre, University of Freiburg, Germany
Since 07/17: Visiting Scientist, La Jolla Institute for Allergy and Immunology, Division of Inflammation Biology, La Jolla, CA, USA
07/17–11/18: Clinical Fellow in Cardiology, Cardiology and Angiology I, University Heart Centre / Medical Center, University of Freiburg, Germany
10/14–06/17: Postdoctoral Fellowship, La Jolla Institute for Allergy and Immunology, Division of Inflammation Biology (PI: Prof. Klaus Ley), La Jolla, CA, USA
02/09–09/14: Clinical Resident, Internal Medicine, University Heart Centre / Medical Center, University of Freiburg, Germany
11/07–01/09: Research Fellowship, Centre for Thrombosis and Myocardial Infarction (PI: Prof. Karlheinz Peter), BakerIDI Heart and Diabetes Institute, Melbourne, Australia
Scientific Activities: - Advisory Board Member, German Atherosclerosis Research Society (DGAF)
- Principle Investigator, International Biomedical Sciences Master Program (IMBS), University of Freiburg/University of Buenos Aires, Argentina
- Member of the scientific program-committee „ATVB/Vascular Discovery 2019 and 2020, American Heart Association (AHA).
- Principal Investigator, MOTI-VATE doctoral study course, University of Freiburg, Germany
- Professional Memberships: German Atherosclerosis Society (DGAF), German Cardiac Society, German Chapter of Young Cardiologists (ESC), American Heart Association (AHA), Member of the ATVB council, German Cardiac Society (DGK), European Society of Cardiology (ESC)
- Reviewer for: Circulation Research, Journal of Pathology, UK Medical Research Council, Dutch Heart Foundation; British Journal of Pharmacology, European Heart Journal, Cardiovascular Research, Scientific Reports, Journal of Medicinal Chemistry, FASEB, Arteriosclerosis, Thrombosis, Vascular Biology (ATVB); Atherosclerosis, Basic Research in Cardiology, Thrombosis and Thrombolysis, PLOSone, European Society of Cardiology (ESC)/Acute Cardiac Care Association, Thrombosis and Haemostasis

Honors

Honors and Awards:

2020–2024: Starting grant, European Research Council (ERC),
2019–2021: Else-Kröner-Fresenius Foundation, project grant
2019–2020: Berta-Ottenstein Advanced Clinician Scientist Program
10/2019: Hans-Jürgen-Bretschneider Poster Price, Basic Science Meeting, German Cardiac Society (DGK)
05/2019: Werner-Hauss Award, German Atherosclerosis Research Society (DGAF)
05/2019: Paul Dudley White International Scholar, Vascular Discovery Meeting 2019, ATVB Council, American Heart Association (AHA)
11/2018: Best Manuscript Award 2018, Circulation Research
04/2018: Research Prize, Heart and Diabetes Working Group, German Society of Cardiology (DGK)
05/2017: Finalist (1 of 4), Irvine Page Young Investigator Award, American Heart Association (AHA)
11/2016: Finalist (1 of 4), Early Career Award, ATVB Council, American Heart Association (AHA)
06/2016: Best Abstract Prize, European Atherosclerosis Society (EAS)
06/2016: Environmental Research Prize, Immanuel Kant Foundation, Freiburg, Germany
12/2015: Acute Cardiac Care Research Prize, European Society of Cardiology (ESC)
06/2015: Travel Grant, Gordon Research Conference for Atherosclerosis
2014–2017: Research Fellowship, German Research Foundation (DFG)
04/2013: Young Investigator Award, German Atherosclerosis Research Society (DGAF)
2013: Inge-Edler Fellowship, German Society of Cardiology (DGK)
2013: Wilhelm-Stoffel Fellowship for Atherosclerosis Research, Merck, Sharpe & Dome (MSD)
02/2012: Poster Prize, German Society for Thrombosis and Haemostasis (GTH)
08/2011: Young Investigator Award in Basic Science, European Society of Cardiology (ESC)
02/2011: Best Abstract Price, German Society for Thrombosis and Haemostasis (GTH)
11/2010: Travel Grant, American Heart Association, ATVB Council
08/2008: Poster Prize, Cardiac Society of Australia and New Zealand (CSANZ)
08/2006: Travel Grant, German Academic Exchange Services (DAAD)

Publications

Selected Publications:

Wolf D, Ley K. Immunity and Inflammation in Atherosclerosis. Circ Res. 2019 Jan 18;124(2):315-327.  Abstract

Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K. Regulatory CD4(+) T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B. Circulation. 2018 Sep 11;138(11):1130-1143.  Abstract

Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D. Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry. Circ Res. 2018 Jun 8;122(12):1675-1688.  Abstract

Anto Michel N, Colberg C, Buscher K, Sommer B, Pramod AB, Ehinger E, Dufner B, Hoppe N, Pfeiffer K, Marchini T, Willecke F, Stachon P, Hilgendorf I, Heidt T, von Zur Muhlen C, von Elverfeldt D, Pfeifer D, Schüle R, Kintscher U, Brachs S, Ley K, Bode C, Zirlik A, Wolf D. Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity. Circ Res. 2018 Mar 2;122(5):693-700.  Abstract

Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc DM, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von Zur Muhlen C, Reinöhl J, Gerhardt T, Plow EF, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A. A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense. Nat Commun. 2018 Feb 6;9(1):525.  Abstract

Wolf D, Bukosza N, Engel D, Poggi M, Jehle F, Anto Michel N, Chen YC, Colberg C, Hoppe N, Dufner B, Boon L, Blankenbach H, Hilgendorf I, von Zur Muhlen C, Reinöhl J, Sommer B, Marchini T, Febbraio MA, Weber C, Bode C, Peter K, Lutgens E, Zirlik A. Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO). Thromb Haemost. 2017 Jan 26;117(2):325-338.  Abstract

Marchini T, Wolf D, Michel NA, Mauler M, Dufner B, Hoppe N, Beckert J, Jäckel M, Magnani N, Duerschmied D, Tasat D, Alvarez S, Reinöhl J, von Zur Muhlen C, Idzko M, Bode C, Hilgendorf I, Evelson P, Zirlik A. Acute exposure to air pollution particulate matter aggravates experimental myocardial infarction in mice by potentiating cytokine secretion from lung macrophages. Basic Res Cardiol. 2016 Jul;111(4):44.  Abstract

Wolf D, Jehle F, Michel NA, Bukosza EN, Rivera J, Chen YC, Hoppe N, Dufner B, Rodriguez AO, Colberg C, Nieto L, Rupprecht B, Wiedemann A, Schulte L, Peikert A, Bassler N, Lozhkin A, Hergeth SP, Stachon P, Hilgendorf I, Willecke F, von Zur Mühlen C, von Elverfeldt D, Binder CJ, Aichele P, Varo N, Febbraio MA, Libby P, Bode C, Peter K, Zirlik A. Coinhibitory suppression of T cell activation by CD40 protects against obesity and adipose tissue inflammation in mice. Circulation. 2014 Jun 10;129(23):2414-25.  Abstract

Wolf D, Jehle F, Ortiz Rodriguez A, Dufner B, Hoppe N, Colberg C, Lozhkin A, Bassler N, Rupprecht B, Wiedemann A, Hilgendorf I, Stachon P, Willecke F, Febbraio M, von zur Muhlen C, Binder CJ, Bode C, Zirlik A, Peter K. CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies. PLoS One. 2012;7(3):e33026.  Abstract

Wolf D, Hohmann JD, Wiedemann A, Bledzka K, Blankenbach H, Marchini T, Gutte K, Zeschky K, Bassler N, Hoppe N, Rodriguez AO, Herr N, Hilgendorf I, Stachon P, Willecke F, Duerschmied D, von zur Muhlen C, Soloviev DA, Zhang L, Bode C, Plow EF, Libby P, Peter K, Zirlik A. Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice. Circ Res. 2011 Nov 11;109(11):1269-79.  Abstract

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