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Marc Timmers Profile Page
Marc Timmers


Lab: Prof. Marc Timmers
Department: Centre for Clinical Research (ZKF)
University Medical Center Freiburg
Address: Breisacher Strasse 66
79106 Freiburg
Phone: +49 761 270 63120
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: - Control of transcription by chromatin modifications
- Epigenetic control of TGF-beta signalling in cancer
- Disturbed epigenetic pathways in kidney and bladder cancer


Education & Training: 1985-1990: PhD, University of Leiden, Leiden, NL
1982-1985: MSc degree in Chemistry, University of Leiden, NL
1979-1982: BSc degree in Chemistry, University of Amsterdam, NL

Employment & Experience: Since 2017: Full Professor of Medical Epigenetics, German Cancer Consortium (DKTK) partner site Freiburg, German Cancer Research Center (DKFZ) and Department of Urology,
University of Freiburg Medical Center, DE
2000-2017: Full Professor of Epigenetics and Gene Regulation, Molecular Cancer Research
and Regenerative Medicine Center, University Medical Center Utrecht, NL
1996-2000: Associate Professor, Laboratory for Physiological Chemistry, Utrecht University, NL
1992-1996: Assistant Professor, Laboratory for Physiological Chemistry, Utrecht University, NL
1990-1991: Postdoctoral research fellow at the Center for Cancer Research, Massachusetts
Institute of Technology, Boston, MA, USA
Scientific Activities: Since 2017: EMBO member
Since 2017: Academia Europaea member, section Biochemistry & Molecular Biology
Since 2016: Editorial board member, Molecular and Cellular Biology
2010-2016: Organizer of EMBL meeting on Transcription and Chromatin, Heidelberg, DE
2009-2015: Editorial board member, The Journal of Biological Chemistry
2001-2003: Instructor Gene Expression summer course, Cold Spring Harbor, NY, USA


Honors and Awards:

1998: Pionier grant Medical Sciences NWO, The Netherlands
1991-1996: Fellowship of the Royal Society for Arts and Sciences (KNAW), NL
1990-1991: NATO Fellowship


Selected Publications:

Capponi S, Stöffler N, Irimia M, Van Schaik FMA, Ondik MM, Biniossek ML, Lehmann L, Mitschke J, Vermunt MW, Creyghton MP, Graybiel AM, Reinheckel T, Schilling O, Blencowe BJ, Crittenden JR, Timmers HTM. Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100. RNA Biol. 2020 Jan;17(1):62-74.  Abstract

Bhuiyan T, Timmers HTM. Promoter Recognition: Putting TFIID on the Spot. Trends Cell Biol. 2019 Sep;29(9):752-763.  Abstract

Kamenova I, Mukherjee P, Conic S, Mueller F, El-Saafin F, Bardot P, Garnier JM, Dembele D, Capponi S, Timmers HTM, Vincent SD, Tora L. Co-translational assembly of mammalian nuclear multisubunit complexes. Nat Commun. 2019 Apr 15;10(1):1740.  Abstract

Antonova SV, Haffke M, Corradini E, Mikuciunas M, Low TY, Signor L, van Es RM, Gupta K, Scheer E, Vos HR, Tora L, Heck AJR, Timmers HTM, Berger I. Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly. Nat Struct Mol Biol. 2018 Dec;25(12):1119-1127.  Abstract

Timmers HTM, Tora L. Transcript Buffering: A Balancing Act between mRNA Synthesis and mRNA Degradation. Mol Cell. 2018 Oct 4;72(1):10-17.  Abstract

Koster MJ, Snel B, Timmers HT. Genesis of chromatin and transcription dynamics in the origin of species. Cell. 2015 May 7;161(4):724-36.  Abstract

Pijnappel WW, Esch D, Baltissen MP, Wu G, Mischerikow N, Bergsma AJ, van der Wal E, Han DW, Bruch Hv, Moritz S, Lijnzaad P, Altelaar AF, Sameith K, Zaehres H, Heck AJ, Holstege FC, Schöler HR, Timmers HT. A central role for TFIID in the pluripotent transcription circuitry. Nature. 2013 Mar 28;495(7442):516-9.  Abstract

van Werven FJ, van Teeffelen HA, Holstege FC, Timmers HT. Distinct promoter dynamics of the basal transcription factor TBP across the yeast genome. Nat Struct Mol Biol. 2009 Oct;16(10):1043-8.  Abstract

van Werven FJ, van Bakel H, van Teeffelen HA, Altelaar AF, Koerkamp MG, Heck AJ, Holstege FC, Timmers HT. Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome. Genes Dev. 2008 Sep 1;22(17):2359-69.  Abstract

Vermeulen M, Mulder KW, Denissov S, Pijnappel WW, van Schaik FM, Varier RA, Baltissen MP, Stunnenberg HG, Mann M, Timmers HT. Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell. 2007 Oct 5;131(1):58-69. Epub 2007 Sep 20.  Abstract

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