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Akos Kulik Profile Page
Akos Kulik


Lab: Prof. Akos Kulik
Department: Institute of Physiology
University of Freiburg
Address: Hermann-Herder-Str. 7
79104 Freiburg
Phone: +49 761 203 67305
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Research Area: Neurosciences
Research Interests: - Functional interaction of metabotropic glutamate and GABA receptors and their effector ion channels in regulation of neurotransmission.
- Studying the dynamics of surface expression and subunit composition of synapse-related proteins, as well as the activity-dependent structural changes of pre- and postsynaptic compartments in cortical principal cells and intereneurons.
- Quantitative analysis of subcellular organization of voltage-activated calcium channels in cortical and spinal cord neurons.


Education & Training: 2012: Habilitation (Dr. Habil.) in Anatomy, University of Freiburg, Germany
1997: Ph.D. degree in Physiology-Neurobiology, Debrecen University Medical School, Debrecen, Hungary
1993: State exam; M.Sc. in biology
1987-1993: Studies in biology, University of Debrecen, Faculty of Science, Debrecen, Hungary
Employment & Experience: Since 2018: Professor, University of Freiburg, Germany
Since 2012: Group Leader at the Institute of Physiology II, University of Freiburg, Germany
2008-2011: Principal Investigator at the Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Freiburg, Germany
2002-2007: Research Associate at the Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Freiburg, Germany
2000-2002: Alexander von Humboldt Fellow at the Institute of Anatomy and Cell Biology, Department of Neuroanatomy, University of Freiburg, Germany
1999-2000: Visiting Scientist at NIPS, Okazaki, Japan
1996-1999: JSPS Postdoctoral Research Scientist at the Department of Morphological Brain Science, Kyoto University, Kyoto, Japan
1995: Visiting student at the MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford, UK
1993-1999: Research Associate at the Department of Anatomy, Debrecen University Medical School, Debrecen, Hungary


Honors and Awards:

2004: Young Investigators’ Award (Japan)
2000-2002: Alexander von Humboldt Fellowship (Germany)
1994: Mezey Roza Award (Hungary)
1994: Abraham Ambrus Prize (Hungary)
1993: Faculty of Science Award (Hungary)


Selected Publications:

Kulik Á, Booker SA, Vida I. Differential distribution and function of GABA(B)Rs in somato-dendritic and axonal compartments of principal cells and interneurons in cortical circuits. Neuropharmacology. 2018 Jul 1;136(Pt A):80-91.  Abstract

Nieto-Rostro M, Ramgoolam K, Pratt WS, Kulik A, Dolphin AC. Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12043-E12052.  Abstract

Booker SA, Loreth D, Gee AL, Watanabe M, Kind PC, Wyllie DJA, Kulik Á, Vida I. Postsynaptic GABA(B)Rs Inhibit L-Type Calcium Channels and Abolish Long-Term Potentiation in Hippocampal Somatostatin Interneurons. Cell Rep. 2018 Jan 2;22(1):36-43.  Abstract

Booker SA, Althof D, Gross A, Loreth D, Müller J, Unger A, Fakler B, Varro A, Watanabe M, Gassmann M, Bettler B, Shigemoto R, Vida I, Kulik Á. KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB Receptor-Mediated Inhibition in Cholecystokinin-Containing Interneurons. Cereb Cortex. 2017 Mar 1;27(3):2318-2334.  Abstract

Althof D, Baehrens D, Watanabe M, Suzuki N, Fakler B, Kulik Á. Inhibitory and excitatory axon terminals share a common nano-architecture of their Cav2.1 (P/Q-type) Ca(2+) channels. Front Cell Neurosci. 2015 Aug 11;9:315.  Abstract

Hainmueller T, Krieglstein K, Kulik A, Bartos M. Joint CP-AMPA and group I mGlu receptor activation is required for synaptic plasticity in dentate gyrus fast-spiking interneurons. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13211-6.  Abstract

Booker SA, Gross A, Althof D, Shigemoto R, Bettler B, Frotscher M, Hearing M, Wickman K, Watanabe M, Kulik Á, Vida I. Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. J Neurosci. 2013 May 1;33(18):7961-74.  Abstract

Parajuli LK, Nakajima C, Kulik A, Matsui K, Schneider T, Shigemoto R, Fukazawa Y. Quantitative regional and ultrastructural localization of the Ca(v)2.3 subunit of R-type calcium channel in mouse brain. J Neurosci. 2012 Sep 26;32(39):13555-67.  Abstract

Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K, Seddik R, Tiao JY, Rajalu M, Trojanova J, Rohde V, Gassmann M, Schulte U, Fakler B, Bettler B. Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature. 2010 May 13;465(7295):231-5.  Abstract

Guetg N, Seddik R, Vigot R, Turecek R, Gassmann M, Vogt KE, Bräuner-Osborne H, Shigemoto R, Kretz O, Frotscher M, Kulik A, Bettler B. The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. J Neurosci. 2009 Feb 4;29(5):1414-23.  Abstract

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