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Christian Schachtrup Profile Page
Christian Schachtrup


Lab: Prof. Dr. Christian Schachtrup
Department: Institute for Anatomy and Cell Biology
Dept. Molecular Embryology
Address: Albertstr. 17
79104 Freiburg
Phone: +49 761 203 5101
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
PhD positions available: YES
Research Area: Neurosciences
Research Interests: - Coagulation cascade and fibrinolytic system in CNS disease
- Molecular mechanisms of glial and fibrotic scar formation
- Neural stem cells in neuronal regeneration


Education & Training: 2000-2003: Dissertation in the lab of Prof. F. Spener, Institute of Biochemistry, Münster, Germany
1994-1999: Diploma in Biology, University of Münster, Germany
Employment & Experience: Since 2017: Heisenberg Professor for Anatomy with a focus on experimental neuroregeneration, University of Freiburg, Germany
2010-2017: Research Group Leader, Institute of Anatomy and Cell Biology, University of Freiburg, Germany
2008-2010: Postdoctoral Scientist, Gladstone Institute of Neurological Disease, San Francisco, USA
2005-2008: Postdoctoral Scientist, University of California, San Diego, USA
2004: Visiting Scientist, Tohoku University, Sendai, Japan


Selected Publications:

Pous L, Deshpande SS, Nath S, Mezey S, Malik SC, Schildge S, Bohrer C, Topp K, Pfeifer D, Fernández-Klett F, Doostkam S, Galanakis DK, Taylor V, Akassoglou K, Schachtrup C. Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling. Nat Commun. 2020 Jan 31;11(1):630.  Abstract

Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 6;96(5):1003-1012.e7.  Abstract

Pfurr S, Chu YH, Bohrer C, Greulich F, Beattie R, Mammadzada K, Hils M, Arnold SJ, Taylor V, Schachtrup K, Uhlenhaut NH, Schachtrup C. The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development. Development. 2017 Nov 1;144(21):3917-3931.  Abstract

Rauch KS, Hils M, Lupar E, Minguet S, Sigvardsson M, Rottenberg ME, Izcue A, Schachtrup C, Schachtrup K. Id3 Maintains Foxp3 Expression in Regulatory T Cells by Controlling a Transcriptional Network of E47, Spi-B, and SOCS3. Cell Rep. 2016 Dec 13;17(11):2827-2836.  Abstract

Bohrer C, Pfurr S, Mammadzada K, Schildge S, Plappert L, Hils M, Pous L, Rauch KS, Dumit VI, Pfeifer D, Dengjel J, Kirsch M, Schachtrup K, Schachtrup C. The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes. EMBO J. 2015 Nov 12;34(22):2804-19.  Abstract

Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions. Nat Neurosci. 2015 Aug;18(8):1077-80.  Abstract

Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A.  2012 Apr 10;109(15):5838-43.  Abstract

Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci. 2010 Apr 28;30(17):5843-54.  Abstract

Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 5;453(7196):807-11.  Abstract

Schachtrup C, Lu P, Jones LL, Lee JK, Lu J, Sachs BD, Zheng B, Akassoglou K. Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11814-9.  Abstract

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