Christoph Schell

Christoph Schell Profile Page

Contact

Lab:	PD Dr. Dr. Christoph Schell
Department:	Institute of Surgical Pathology, Faculty of Medicine, University of Freiburg
Address:	Breisacher Strasse 115a D-79106 Freiburg Germany
Phone:	+49 761 270 80060
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
PhD positions available:	YES
Research Area:	Molecular Medicine
Research Interests:	-Cell-matrix interactions in specialized renal epithelial cells (incldg. podocytes, proximal renal epithelial cells) -Characterization of key events modulating chronic interstitial fibrosis -Characterization and functional elucidation of the tumor matrisome in clear cell renal cell carcinoma (ccRCC) -Functional analysis of molecular subtypes of urothelial cell carcinoma

CV

Education & Training:

2011–2014: PhD, Spemann Graduate School of Biology and Medicine (SGBM), Faculty of Biology, University of Freiburg, Germany
2011: MD (Dr. med) – Institute of Anatomy & Cell Biology, LMU Munich, Germany
2002–2008: Medical School, University of Munich (LMU & TU), Germany

Employment & Experience:

2020: Venia legendi – University Freiburg
2017–2020: Clinician Scientist Fellow – Berta-Ottenstein Program, Faculty of Medicine, University Freiburg
Since 2016: Research group leader (Experimental Nephro- &Uropathology)
Since 2016: Resident in Pathology, Institute of Surgical Pathology, University of Freiburg
2011–2015: Research Fellow and Clinician Scientist in Nephrology, University Hospital Freiburg
2010–2011: Residency in Medicine, University Hospital Freiburg
2009–2010: Residency in Medicine, University Hospital Regensburg

Honors

Honors and Awards:

2013–2014: Clinician Scientist Fellowship – EKFS (NAKSYS)
2014: Research Stipend – German Society of Nephrology (DGFN)

Publications

Selected Publications:

Rogg M, Maier JI, Dotzauer R, Artelt N, Kretz O, Helmstädter M, Abed A, Sammarco A, Sigle A, Sellung D, Dinse P, Reiche K, Yasuda-Yamahara M, Biniossek ML, Walz G, Werner M, Endlich N, Schilling O, Huber TB, Schell C. SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance. J Am Soc Nephrol. 2021 Mar;32(3):563-579. Abstract

Brinkkoetter PT, Bork T, Salou S, Liang W, Mizi A, Özel C, Koehler S, Hagmann HH, Ising C, Kuczkowski A, Schnyder S, Abed A, Schermer B, Benzing T, Kretz O, Puelles VG, Lagies S, Schlimpert M, Kammerer B, Handschin C, Schell C, Huber TB. Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Rep. 2019 Apr 30;27(5):1551-1566.e5. Abstract

Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda-Yamahara M, Sigle A, Maier JI, Grahammer F, Siegerist F, Artelt N, Endlich N, Kerjaschki D, Arnold HH, Dengjel J, Rogg M, Huber TB. ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier. Dev Cell. 2018 Dec 17;47(6):741-757.e8. Abstract

Yasuda-Yamahara M, Rogg M, Frimmel J, Trachte P, Helmstaedter M, Schroder P, Schiffer M, Schell C, Huber TB. FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology. Matrix Biol. 2018 Aug;68-69:263-279. Abstract

Rogg M, Yasuda-Yamahara M, Abed A, Dinse P, Helmstädter M, Conzelmann AC, Frimmel J, Sellung D, Biniossek ML, Kretz O, Grahammer F, Schilling O, Huber TB, Schell C. The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton. Sci Rep. 2017 Nov 21;7(1):15910. Abstract

Schell C, Rogg M, Suhm M, Helmstädter M, Sellung D, Yasuda-Yamahara M, Kretz O, Küttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB. The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4621-E4630. Abstract

Schell C, Kretz O, Liang W, Kiefer B, Schneider S, Sellung D, Bork T, Leiber C, Rüegg MA, Mallidis C, Schlatt S, Mayerhofer A, Huber TB, Grahammer F. The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility. Am J Pathol. 2016 Feb;186(2):324-36. Abstract

Albert GI, Schell C, Kirschner KM, Schäfer S, Naumann R, Müller A, Kretz O, Kuropka B, Girbig M, Hübner N, Krause E, Scholz H, Huber TB, Knobeloch KP, Freund C. The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function. J Mol Cell Biol. 2015 Oct;7(5):402-14. Abstract

Schell C, Kretz O, Bregenzer A, Rogg M, Helmstädter M, Lisewski U, Gotthardt M, Tharaux PL, Huber TB, Grahammer F. Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response. PLoS One. 2015 Jun 15;10(6):e0129424. Abstract

Schell C, Baumhakl L, Salou S, Conzelmann AC, Meyer C, Helmstädter M, Wrede C, Grahammer F, Eimer S, Kerjaschki D, Walz G, Snapper S, Huber TB. N-wasp is required for stabilization of podocyte foot processes. J Am Soc Nephrol. 2013 Apr;24(5):713-21. Abstract

SGBM PhD students

SGBM PhD students:

Maximilian Wess (since February 2021)