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Florian Full


Lab: Dr. Florian Full
Department: Institute for Virology
Address: Hermann-Herder-Straße 11
79104 Freiburg
Phone: +49 761 270 83720
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: • Elucidating the role of the germline transcription factor DUX4 in herpesviral infections.
• Evaluate the transcription factor DUX4 as novel target for anti-herpesviral therapy.
• Characterize the epigenetics of the herpesviral genome.
• Identification and characterization of antiviral restriction factors for poxviruses.


Education & Training: 2010: PhD (Dr. rer. nat.) in Virology / Immunology, University Erlangen-Nürnberg, Germany
2005: Diploma in Biology, University Erlangen-Nürnberg, Germany
Employment & Experience: since 04/2021: Head of BMBF junior research group "Duxdrugs", Institute of Virology, University Freiburg Medical Center, Freiburg, Germany
01/2021-03/2021: Head of BMBF junior research group "Duxdrugs", Institute of Virology, University Hospital Erlangen, Germany
2019-2020: Research Scientist, Institute of Virology, University Hospital Erlangen, Germany
2017-2019: Marie Skłodowska Curie Fellowship of the EU, Institute of Virology, University Hospital Erlangen, Germany
2013-2016: Research Fellow (DFG-Scholarship), Harvard Medical School, Boston and The University of Chicago, USA (Laboratory of Prof. Michaela U. Gack)
2011-2012: Visiting scientist (3 months), Harvard Medical School, Southborough, MA, USA
(Laboratory of Prof. Ronald C. Desrosiers)
2010-2012: Postdoctoral Fellow, Institute of Virology, University Hospital Erlangen, Germany (Laboratory of Prof. Dr. Armin Ensser)


Selected Publications:

Walter S, Franke V, Drayman N, Wyler E, Tay S, Landthaler M, Akalin A, Ensser A and Full F. (2021) Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression.  BioRxivAbstract

Xiao H, Wyler E, Milek M, Grewe B, Kirchner P, Ekici A, Silva ABOV, Jungnickl D, Full F, Thomas M, Landthaler M, Ensser A, Überla K. CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs. mBio. 2021 Jan 19;12(1):e02525-20.  Abstract

Full F, van Gent M, Sparrer KMJ, Chiang C, Zurenski MA, Scherer M, Brockmeyer NH, Heinzerling L, Stürzl M, Korn K, Stamminger T, Ensser A, Gack MU. Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Nat Microbiol. 2019 Jan;4(1):164-176.  Abstract

Full F, Ensser A. Early Nuclear Events after Herpesviral Infection. J Clin Med. 2019 Sep 7;8(9):1408.  Abstract

de Jong SJ, Créquer A, Matos I, Hum D, Gunasekharan V, Lorenzo L, Jabot-Hanin F, Imahorn E, Arias AA, Vahidnezhad H, Youssefian L, Markle JG, Patin E, D'Amico A, Wang CQF, Full F, Ensser A, Leisner TM, Parise LV, Bouaziz M, Maya NP, Cadena XR, Saka B, Saeidian AH, Aghazadeh N, Zeinali S, Itin P, Krueger JG, Laimins L, Abel L, Fuchs E, Uitto J, Franco JL, Burger B, Orth G, Jouanguy E, Casanova JL. The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses. J Exp Med. 2018 Sep 3;215(9):2289-2310.  Abstract

Full F, Hahn AS, Großkopf AK, Ensser A. Gammaherpesviral Tegument Proteins, PML-Nuclear Bodies and the Ubiquitin-Proteasome System. Viruses. 2017 Oct 21;9(10):308.  Abstract

Sparrer KMJ, Gableske S, Zurenski MA, Parker ZM, Full F, Baumgart GJ, Kato J, Pacheco-Rodriguez G, Liang C, Pornillos O, Moss J, Vaughan M, Gack MU. TRIM23 mediates virus-induced autophagy via activation of TBK1. Nat Microbiol. 2017 Nov;2(11):1543-1557.  Abstract

Full F, Gack MU. Delicate coordination of TRIM21's dual activity in virus neutralization and signaling. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9797-8.  Abstract

Full F, Jungnickl D, Reuter N, Bogner E, Brulois K, Scholz B, Stürzl M, Myoung J, Jung JU, Stamminger T, Ensser A. Kaposi's sarcoma associated herpesvirus tegument protein ORF75 is essential for viral lytic replication and plays a critical role in the antagonization of ND10-instituted intrinsic immunity. PLoS Pathog. 2014 Jan;10(1):e1003863.  Abstract

Full F, Reuter N, Zielke K, Stamminger T, Ensser A. Herpesvirus saimiri antagonizes nuclear domain 10-instituted intrinsic immunity via an ORF3-mediated selective degradation of cellular protein Sp100. J Virol. 2012 Apr;86(7):3541-53.  Abstract

Full F
, Lehner M, Thonn V, Goetz G, Scholz B, Kaufmann KB, Mach M, Abken H, Holter W, Ensser A. T cells engineered with a cytomegalovirus-specific chimeric immunoreceptor. J Virol. 2010 Apr;84(8):4083-8.  Abstract

SGBM PhD students

SGBM PhD students:

Eva Neugebauer (since April 2021)

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