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Máté Döbrössy


Lab: PD Dr. Mate Daniel Döbrössy
Department: Dept. of Stereotactic and Functional Neurosurgery
University Medical Center
Address: Breisacher Str. 64
79106 Freiburg
Phone: +49 761 270 50630
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Neurosciences
Research Interests: • Preclinical rodent models of Psychiatric Disorders, with special focus on Depression
• Wide spectrum behavioral testing of rodents, specializing on tests sensitive to “depressive-like” phenotypes
• Investigating the biological mechanisms of established and novel neurostimulation modalities (DBS, optogenetics, focused ultrasound) in experimental models of Depression
• Investigating the neurocircuitry associated with Depression using non-invasive imaging (MRI, PET) and viral based neural tracking methods
• Cross-species anatomical and histological comparison of the midbrain dopaminergic system


Selected Publications:

Holz A, Mülsch F, Schwarz MK, Hollmann M, Döbrössy MD, Coenen VA, Bartos M, Normann C, Biber K, van Calker D, Serchov T. Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation. Neuron. 2019 Oct 23;104(2):338-352.e7.  Abstract

Serchov T, Schwarz I, Theiss A, Sun L, Holz A, Döbrössy MD, Schwarz MK, Normann C, Biber K, van Calker D. Enhanced adenosine A1 receptor and Homer1a expression in hippocampus modulates the resilience to stress-induced depression-like behavior. Neuropharmacology. 2020 Jan 1;162:107834.  Abstract

Thiele S, Sörensen A, Weis J, Braun F, Meyer PT, Coenen VA, Döbrössy MD. Deep Brain Stimulation of the Medial Forebrain Bundle in a Rodent Model of Depression: Exploring Dopaminergic Mechanisms with Raclopride and Micro-PET. Stereotact Funct Neurosurg. 2020;98(1):8-20.  Abstract

Ashouri Vajari D, Ramanathan C, Tong Y, Stieglitz T, Coenen VA, Döbrössy MD. Medial forebrain bundle DBS differentially modulates dopamine release in the nucleus accumbens in a rodent model of depression. Exp Neurol. 2020 May;327:113224.  Abstract

Coenen VA, Schlaepfer TE, Sajonz B, Döbrössy M, Kaller CP, Urbach H, Reisert M. Tractographic description of major subcortical projection pathways passing the anterior limb of the internal capsule. Corticopetal organization of networks relevant for psychiatric disorders. Neuroimage Clin. 2020;25:102165.  Abstract

Döbrössy MD, Ramanathan C, Ashouri Vajari D, Tong Y, Schlaepfer T, Coenen VA. Neuromodulation in Psychiatric disorders: Experimental and Clinical evidence for reward and motivation network Deep Brain Stimulation: Focus on the medial forebrain bundle. Eur J Neurosci. 2021 Jan;53(1):89-113.  Abstract

Coenen VA, Döbrössy MD, Teo SJ, Wessolleck J, Sajonz BEA, Reinacher PC, Thierauf-Emberger A, Spittau B, Leupold J, von Elverfeldt D, Schlaepfer TE, Reisert M. Diverging prefrontal cortex fiber connection routes to the subthalamic nucleus and the mesencephalic ventral tegmentum investigated with long range (normative) and short range (ex-vivo high resolution) 7T DTI. Brain Struct Funct. 2022 Jan;227(1):23-47.  Abstract

Tong Y, Pfeiffer L, Serchov T, Coenen VA, Döbrössy MD. Optogenetic stimulation of ventral tegmental area dopaminergic neurons in a female rodent model of depression: The effect of different stimulation patterns. J Neurosci Res. 2022 Mar;100(3):897-911.  Abstract

Coenen VA, Schlaepfer TE, Sajonz BEA, Reinacher PC, Döbrössy MD, Reisert M. "The Heart Asks Pleasure First"-Conceptualizing Psychiatric Diseases as MAINTENANCE Network Dysfunctions through Insights from slMFB DBS in Depression and Obsessive-Compulsive Disorder. Brain Sci. 2022 Mar 25;12(4):438.  Abstract

Bühning F, Miguel Telega L, Tong Y, Pereira J, Coenen VA, Döbrössy MD. Electrophysiological and molecular effects of bilateral deep brain stimulation of the medial forebrain bundle in a rodent model of depression. Exp Neurol. 2022 Sep;355:114122.  Abstract

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