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Andreas Diefenbach


Lab: Prof.Dr. Andreas Diefenbach
Department: Institute of Medical Microbiology & Hygiene
Phone: 203 6522
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: NO
Research Interests: Innate immune recognition, Stimulatory NK cell receptors, Mechanisms of NK cell self tolerance


Education & Training: 1986-1989: Study of Philosophy (M.A., M.D.), Friedrich-Alexander-University Erlangen, Germany
1990-1996: Study of Medicine/Immunology (M.D.), Friedrich-Alexander-University Erlangen, Germany
1997: PhD, Friedrich-Alexander-University Erlangen, Germany
Employment & Experience: 1998-2002: Postdoctoral Fellow, Immunology, University of California, Berkeley
2003-2006: Assistant Professor (tenure track), Immunology, Skirball Institute of Biomolecular Medicine, New York University, New York
2006-present: Professor (with tenure), Microbiology & Molecular Immunology, Albert-Ludwigs-University, Freiburg
Scientific Activities: 2003-2006 Member, Cancer Immunology, Faculty Search Committee, New York University
2003-present Member, New York University Cancer Institute
2003-present Member, Helen and Martin Kimmel Stem Cell Center (NYU)
2004-present Member, Immunology Integrated Review Group (IMM IRG), Center for Scientific Review, National Institutes of Health
2004-present Member, Stem Cell Transplantation Review Group, National Cancer Institute, National Institutes of Health
2005-present Reviewer (Fachgutachter), Deutsche Forschungsgemeinschaft
2007-present Principal Investigator, Spemann Graduate School of Biology and Medicine (SGBM)
2007-present Principal Investigator, DFG-GRK1104: From cells to organs: Molecular mechanisms of organogenesis
2007-present Associate Editor, Journal of Immunology


Honors and Awards:

1993-1994: Clinical Training Award, Dr. Carl Duisberg Stiftung
1997: summa cum laude, University of Erlangen
1999-2000: Postdoctoral Research Fellowship, Deutsche Forschungsgemeinschaft
2000-2002: Postdoctoral Research Fellowship for Physicians, Howard Hughes Medical Institute
2003-2006: Irene Diamond Professorship for Immunology
2004-2005: Whitehead Fellowship for Junior Faculty in Biomedical Sciences
2009: Kavli Fellow, National Academy of Sciences USA & Alexander-von-Humboldt-Stiftung
2010: Hauptpreis, Deutsche Gesellschaft für Mikrobiologie und Hygiene
2012: ERC Starting Grant


Selected Publications:

Klose, C.S.N., E.A.Kiss, V.Schwierzeck, K.Ebert, T.Hoyler, Y.d’Hargues, N.Göppert, A.L.Croxford, A.Waisman, Y.Tanriver, and A.Diefenbach. 2013. A T-bet gradient controls the fate and function of CCR6- RORγt+ innate lymphoid cells. Nature, 494:261-265. Abstract

Hoyler, T., C.S.N.Klose, A.Souabni, A.Turqueti-Neves, D.Pfeifer, E.L.Rawlins, D.Voehringer, M.Busslinger, and A.Diefenbach. 2012. The transcription factor Gata3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity. 37:634-648. Abstract

Ganal, S.C., S.L.Sanos, C.Kallfass, K.Oberle, C.Johner, C.Kirschning, S.Lienenklaus, S.Weiss, P.Staeheli, P.Aichele, and A.Diefenbach. 2012. Priming of natural killer cells by non-mucosal mononuclear phagocytes requires instructive signals from the commensal microbiota. Immunity. 37:171-186. Abstract

Diefenbach, A. 2012. Preview: Interleukin 22, the guardian of the intestinal stem cell niche? Immunity. 34:196-198. Abstract

Klose, C.S.N., T.Hoyler, E.A.Kiss, Y.Tanriver, and A.Diefenbach. 2012. Transcriptional control of innate lymphocyte fate decisions. Curr. Opin. Immunol. 24:290-296. Published online 10.1016/j.coi.2012.04.004. Abstract

Kiss, E.A., C.Vonarbourg, S.Kopfmann, E.Hobeika, D.Finke, C.Esser, and A.Diefenbach. 2011. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science. 334:1561-1565. [Science Signaling: Signaling Breakthrough of the Year 2011] Abstract

Vonarbourg, C., A.Mortha, V.L.Bui, P.Hernandez, E.A.Kiss, T.Hoyler, M.Flach, B.Bengsch, R.Thimme, C.Hölscher, M.Hönig, U.Pannicke, K.Schwarz, C.F.Ware, D.Finke, and A.Diefenbach. 2010. Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt+ innate lymphocytes. Immunity. 33:736-751. [Featured Article of the Month] Abstract

Accompanied by: Preview: Strober, W. 2010. The LTi cell, an immunologic chameleon. Immunity. 33:650-652.

Sanos, S.L., V.L.Bui, A.Mortha, K.Oberle, C.Heners, C.Johner, and A.Diefenbach. 2009. RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nature Immunology. 10:83-91. Abstract
Accompanied by: News & Views: Malmberg, K.J. and Ljunggren, H.G. 2009. Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes. Nature Immunology. 10:11-12.

Lucas, M., W.Schachterle, K.Oberle, P.Aichele, and A.Diefenbach. 2007. Dendritic Cells Prime Natural Killer Cells by trans-Presenting Interleukin 15. Immunity. 26:503-517.  Abstract


SGBM PhD students

SGBM PhD students:


Track 1
Christoph Klose (06/2007 - 11/2011)
Elina Kiss (04/2009 - 11/2012)

Track 2
Arthur Mortha (06/2007 - 05/2011)
Stephanie Ganal (06/2009 - 07/2013)

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