Andreas Hecht

Andreas Hecht Profile Page

Contact

Lab:	Prof. Dr. Andreas Hecht
Department:	Institute of Molecular Medicine and Cell Research
Address:	Stefan-Meier-Str. 17 D-79104 Freiburg
Phone:	+49 761 203 9608
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.mol-med.uni-freiburg.de/mom/hecht
PhD positions available:	NO
Research Area:	Molecular Medicine
Research Interests:	Transcriptional regulation and epigenetics Signal transduction Wnt/beta-catenin signaling Colorectal cancer

CV

Education & Training:	1987-1990: Dr. rer. nat. in Molecular Biology, University of Heidelberg 1984-1987: Biology (Diplom) at University of Heidelberg 1982-1984: Biology (Vordiplom) at University of Regensburg
Employment & Experience:	since 2002: Akademischer Oberrat, Institute of Molecular Medicine and Cell Research, University of Freiburg 1996 - 2002: Senior scientist/group leader in the department of Rolf Kemler, Max-Planck-Institute of Immunobiology, Freiburg 1992 - 1995: Postdoctoral fellow in the lab of Michael Grunstein, University of California, Los Angeles, USA 1990 - 1992: Postdoctoral fellow in the lab of Albrecht E. Sippel, University of Freiburg
Scientific Activities:	Supervision of more than 30 graduated BSc, MSc, Diploma and PhD students (Biology and Molecular Medicine). Referee duties for German Science Foundation (DFG), Swiss National Science Foundation, French National Research Agency (ANR), Alexander von Humboldt Foundation, Cancer Research UK, and for biological journals such as EMBO Molecular Medicine, EMBO Reports, The EMBO Journal, Oncogene, Nucleic Acids Resarch, Cell Death and Differentiation, Molecular and Cellular Biology and others. Executive board member Spemann Graduate school of Biology and Medicine 2008-2012. Associate member BIOSS Center for Biological Signalling Studies since 2011.

Honors

Honors and Awards:

2006: Extracurricular professorship (apl. Prof.), Faculty of Biology, University of Freiburg
2001: Habilitation, University of Freiburg, Department of Prof. Albrecht Sippel
1992-1994: Long Term Postdoctoral Fellowship of the DFG
1992: Award for young scientists from the "Gesellschaft zur Förderung der molekularbiologischen Forschung in Heidelberg e. V".

Publications

Selected Publications:

Flum M, Dicks S, Teng YH, Schrempp M, Nyström A, Boerries M, Hecht A. Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT. Oncogene. 2022 Jan 24. Abstract

Frey P, Devisme A, Schrempp M, Andrieux G, Boerries M, Hecht A. Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1. Cancers (Basel). 2020 Apr 21;12(4):1019. Abstract

Wenzel J, Rose K, Haghighi EB, Lamprecht C, Rauen G, Freihen V, Kesselring R, Boerries M, Hecht A. Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells. Oncogene. 2020 May;39(19):3893-3909. Abstract

Beyes S, Andrieux G, Schrempp M, Aicher D, Wenzel J, Antón-García P, Boerries M, Hecht A. Genome-wide mapping of DNA-binding sites identifies stemness-related genes as directly repressed targets of SNAIL1 in colorectal cancer cells. Oncogene. 2019 Oct;38(40):6647-6661. Abstract

Jägle S, Busch H, Freihen V, Beyes S, Schrempp M, Boerries M, Hecht A. SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells. PLoS Genet. 2017 Nov 20;13(11):e1007109. Abstract

Rönsch K, Jägle S, Rose K, Seidl M, Baumgartner F, Freihen V, Yousaf A, Metzger E, Lassmann S, Schüle R, Zeiser R, Michoel T, Hecht A. SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. Mol Oncol. 2015 Feb;9(2):335-54. Abstract

Jägle S, Rönsch K, Timme S, Andrlová H, Bertrand M, Jäger M, Proske A, Schrempp M, Yousaf A, Michoel T, Zeiser R, Werner M, Lassmann S, Hecht A. Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4886-91. Abstract

Weise A, Bruser K, Elfert S, Wallmen B, Wittel Y, Wöhrle S, Hecht A. Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res. 2010 Apr;38(6):1964-81. Abstract

Hecht A, Strahl-Bolsinger S, Grunstein M. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin. Nature. 1996 Sep 5;383(6595):92-6. Abstract

Hecht A, Laroche T, Strahl-Bolsinger S, Gasser SM, Grunstein M. Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell. 1995 Feb 24;80(4):583-92. Abstract

SGBM PhD students

SGBM PhD students:

Alumni

Marion Flum (01/2017 - 03/2021)

Patrick Frey (01/2017 - 02/2021)

Britta Wallmen (11/2007 - 06/2012)