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Andreas Hecht Profile Page
Andreas Hecht

Contact

Lab: Prof. Dr. Andreas Hecht
Department: Institute of Molecular Medicine and Cell Research
Address: Stefan-Meier-Str. 17
D-79104 Freiburg
Phone: +49 761 203 9608
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.mol-med.uni-freiburg.de/mom/hecht
PhD positions available: NO
Research Area: Molecular Medicine
Research Interests: Transcriptional regulation and epigenetics
Signal transduction
Wnt/beta-catenin signaling
Colorectal cancer

CV

Education & Training: 1987-1990: Dr. rer. nat. in Molecular Biology, University of Heidelberg
1984-1987: Biology (Diplom) at University of Heidelberg
1982-1984: Biology (Vordiplom) at University of Regensburg
Employment & Experience: since 2002: Akademischer Oberrat, Institute of Molecular Medicine and Cell Research, University of Freiburg
1996 - 2002: Senior scientist/group leader in the department of Rolf Kemler, Max-Planck-Institute of Immunobiology, Freiburg
1992 - 1995: Postdoctoral fellow in the lab of Michael Grunstein, University of California, Los Angeles, USA
1990 - 1992: Postdoctoral fellow in the lab of Albrecht E. Sippel, University of Freiburg
Scientific Activities: Supervision of more than 30 graduated BSc, MSc, Diploma and PhD students (Biology and Molecular Medicine).
Referee duties for German Science Foundation (DFG), Swiss National Science Foundation, French National Research Agency (ANR), Alexander von Humboldt Foundation, Cancer Research UK, and for biological journals such as EMBO Molecular Medicine, EMBO Reports, The EMBO Journal, Oncogene, Nucleic Acids Resarch, Cell Death and Differentiation, Molecular and Cellular Biology and others.
Executive board member Spemann Graduate school of Biology and Medicine 2008-2012.
Associate member BIOSS Center for Biological Signalling Studies since 2011.

Honors

Honors and Awards:

2006:  Extracurricular professorship (apl. Prof.), Faculty of Biology, University of Freiburg
2001:  Habilitation, University of Freiburg, Department of Prof. Albrecht Sippel
1992-1994:  Long Term Postdoctoral Fellowship of the DFG
1992:  Award for young scientists from the "Gesellschaft zur Förderung der molekularbiologischen Forschung in Heidelberg e. V".

Publications

Selected Publications:

Schnappauf O, Beyes S, Dertmann A, Freihen V, Frey P, Jägle S, Rose K, Michoel T, Grosschedl R & Hecht A (2016), “Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing.” Biochim. Biophys. Acta 1859, 1353-1367.  Abstract

Rönsch K, Jägle S, Rose K, Seidl M, Baumgartner F, Freihen V, Yousaf A, Metzger E, Lassmann S, Schüle R, Zeiser R, Michoel T & Hecht A (2015), “SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. Mol. Oncol. 9, 335–354. Abstract

Jägle S, Rönsch K, Timme S, Andrlová H, Bertrand M, Jäger M, Proske A, Schrempp M, Yousaf A, Michoel T, Zeiser R, Werner M, Lassmann S & Hecht A (2014), “Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer.” Proc. Natl. Acad. Sci. U.S.A. 111, 4886–4891. Abstract

Wallmen B, Schrempp M & Hecht A (2012), “Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression.” Nucl. Acids Res. 40, 9455-9469. Abstract

Rönsch K, Jäger M, Schöpflin A, Danciu M, Laßmann S & Hecht A (2011), “Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer.” Epigenetics 6, 610-622. Abstract

Weise A, Bruser K, Elfert S, Wallmen B, Wittel Y, Wöhrle S & Hecht A (2010), "Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets." Nucl. Acids Res. 38, 1964-1981. Abstract

Wöhrle S, Wallmen B & Hecht A (2007), "Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-Cell factors." Mol. Cell. Biol. 27, 8164-8177. Abstract

Hecht A, Vleminckx K, Stemmler MP, van Roy F & Kemler R (2000), "The p300/CBP acetyltransferases function as transcriptional coactivators of β-catenin in vertebrates." EMBO J. 19, 1839-1850. Abstract

Hecht A, Strahl-Bolsinger S & Grunstein M (1996), "Spreading of transcriptional repressor SIR3 from telomeric heterochromatin." Nature 383, 92-96. Abstract

Hecht A, Laroche T, Strahl-Bolsinger S, Gasser, SM & Grunstein M (1995), "Histone H3 and H4 N termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast." Cell 80, 583-592. Abstract

SGBM PhD students

SGBM PhD students:

Fast Track:
Patrick Frey (since January 2017)

Track 1:
Marion Flum (since January 2017)

Alumni

Track 2:
Britta Wallmen (11/2007 - 06/2012)

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