 |
Contact
| Lab: | Prof. Dr. Andreas Hecht |
| Department: | Institute of Molecular Medicine and Cell Research |
| Address: | Stefan-Meier-Str. 17 D-79104 Freiburg |
| Phone: | +49 761 203 9608 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | www.mol-med.uni-freiburg.de/mom/hecht |
| PhD positions available: | NO |
| Research Area: | Molecular Medicine |
| Research Interests: | Transcriptional regulation and epigenetics Signal transduction Wnt/beta-catenin signaling Colorectal cancer |
CV
| Education & Training: | 1987-1990: Dr. rer. nat. in Molecular Biology, University of Heidelberg 1984-1987: Biology (Diplom) at University of Heidelberg 1982-1984: Biology (Vordiplom) at University of Regensburg |
| Employment & Experience: | since 2002: Akademischer Oberrat, Institute of Molecular Medicine and Cell Research, University of Freiburg 1996 - 2002: Senior scientist/group leader in the department of Rolf Kemler, Max-Planck-Institute of Immunobiology, Freiburg 1992 - 1995: Postdoctoral fellow in the lab of Michael Grunstein, University of California, Los Angeles, USA 1990 - 1992: Postdoctoral fellow in the lab of Albrecht E. Sippel, University of Freiburg |
| Scientific Activities: | Supervision of more than 30 graduated BSc, MSc, Diploma and PhD students (Biology and Molecular Medicine). Referee duties for German Science Foundation (DFG), Swiss National Science Foundation, French National Research Agency (ANR), Alexander von Humboldt Foundation, Cancer Research UK, and for biological journals such as EMBO Molecular Medicine, EMBO Reports, The EMBO Journal, Oncogene, Nucleic Acids Resarch, Cell Death and Differentiation, Molecular and Cellular Biology and others. Executive board member Spemann Graduate school of Biology and Medicine 2008-2012. Associate member BIOSS Center for Biological Signalling Studies since 2011. |
Honors
| Honors and Awards: | 2006: Extracurricular professorship (apl. Prof.), Faculty of Biology, University of Freiburg |
Publications
| Selected Publications: | Schnappauf O, Beyes S, Dertmann A, Freihen V, Frey P, Jägle S, Rose K, Michoel T, Grosschedl R & Hecht A (2016), “Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing.” Biochim. Biophys. Acta 1859, 1353-1367. Abstract Rönsch K, Jägle S, Rose K, Seidl M, Baumgartner F, Freihen V, Yousaf A, Metzger E, Lassmann S, Schüle R, Zeiser R, Michoel T & Hecht A (2015), “SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. Mol. Oncol. 9, 335–354. Abstract Jägle S, Rönsch K, Timme S, Andrlová H, Bertrand M, Jäger M, Proske A, Schrempp M, Yousaf A, Michoel T, Zeiser R, Werner M, Lassmann S & Hecht A (2014), “Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer.” Proc. Natl. Acad. Sci. U.S.A. 111, 4886–4891. Abstract Wallmen B, Schrempp M & Hecht A (2012), “Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression.” Nucl. Acids Res. 40, 9455-9469. Abstract Rönsch K, Jäger M, Schöpflin A, Danciu M, Laßmann S & Hecht A (2011), “Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer.” Epigenetics 6, 610-622. Abstract Weise A, Bruser K, Elfert S, Wallmen B, Wittel Y, Wöhrle S & Hecht A (2010), "Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/β-catenin targets." Nucl. Acids Res. 38, 1964-1981. Abstract Wöhrle S, Wallmen B & Hecht A (2007), "Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-Cell factors." Mol. Cell. Biol. 27, 8164-8177. Abstract Hecht A, Vleminckx K, Stemmler MP, van Roy F & Kemler R (2000), "The p300/CBP acetyltransferases function as transcriptional coactivators of β-catenin in vertebrates." EMBO J. 19, 1839-1850. Abstract Hecht A, Strahl-Bolsinger S & Grunstein M (1996), "Spreading of transcriptional repressor SIR3 from telomeric heterochromatin." Nature 383, 92-96. Abstract Hecht A, Laroche T, Strahl-Bolsinger S, Gasser, SM & Grunstein M (1995), "Histone H3 and H4 N termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast." Cell 80, 583-592. Abstract |
SGBM PhD students
| SGBM PhD students: | Fast Track: Alumni Track 2: |
