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Ralf Baumeister Profile Page
Ralf Baumeister


Lab: Prof. Dr. Ralf Baumeister
Department: Bioinformatics and Molecular Biology (Bio3, Faculty of Biology)
Center for Biochemistry and Molecular Cell Research (ZBMZ, Faculty of Medicine)

Address: Schänzlestr. 1
D-79104 Freiburg
Phone: +49 (761) 203 8350
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster: Member
PhD positions available: YES
Research Area: Developmental Biology
Research Interests: Molecular genetics and biochemistry of aging and age-related diseases


Education & Training: 1982-1987 Diploma in Biology, University of Erlangen/Nürnberg
1987-1992 PhD in Microbiology, University of Erlangen-Nürnberg
2001 Habilitation in Biochemistry, LMU Munich, (Prof. Dr. E. Winnacker)

Employment & Experience: since 2006 W3 Professor (Ordinarius), Faculties of Biology and Medicine
2003-2006 C4 Professor (Ordinarius), Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg
2000-2003 C3 Professor (Metabolic Chemistry), Adolf-Butenandt-Inst., Faculty of Medicine, LMU Munich
1995-2000 Group Leader Neurogenetics, Genzentrum LMU Munich
1992-1995 Postdoctorate, Harvard Med. School, Mass. General Hospital, Boston, USA
Scientific Activities: 2010-2012 Internal Senior Fellow FRIAS LIFENET
2007-2010 Director of LIFENET at FRIAS – Freiburg Institute of Advanced Studies
2007-2008 Director of Institute of Biology 3, Faculty of Biology
2005-2010 Director of ZBSA (Zentrum für Biosystemanalyse) Freiburg
1998 Founder of the Biotech Company ELEGENE Inc.


Honors and Awards:
1988-1990: Stipend, Begabtenförderung des Freistaats Bayern
1988: Eva-Schleip Stipend, Erlangen
1989: EMBO Fellowship, Research Visit at Karolinska Institute, Stockholm
1993: PhD Prize, VAAM e.V (Vereinigung f. Allg. und Angew. Mikrobiologie)
1993-1995: EMBO and DFG (German Research Council) Research fellowships
1995: American Cancer Society Mass. Div., Research fellowship
2001: Philip-Morris Research Prize
2002: Familie-Hansen Research Prize of Bayer AG
2003: Recipient of Qualitätsoffensive Program by the State of Baden-W.
2009: Alzheimer Research Prize 2008 of the Hans and Ilse Breuer Foundation


Selected Publications:

Wolf, T., Q, W., Schindler, V., Runkel, E.D., and Baumeister, R. (2014) Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutants. Exp Gerontol. 2014 Apr 15. pii: S0531-5565(14)00123-5. doi: 10.1016/j.exger.2014.04.002. [Epub ahead of print]. Abstract

Runkel, ED., Baumeister, R., and Schulze, E (2014) Mitochondrial stress: Balancing friend and foe. Exp Gerontol. 2014 Mar 3. pii: S0531-5565(14)00070-9. doi: 10.1016/j.exger.2014.02.013. [Epub ahead of print] Review. Abstract

Cabello, J., Sämann, J., Gómez-Orte, E., Erazo, T., Coppa, A., Pujol, A., Büssing, I, Schulze, B, Lizcano, J.M., Ferrer*, I., Baumeister*, R., Dalfo, E. (2014) pdr-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in C. elegans. Cell Death Dis. Mar 13;5:e1120. doi: 10.1038/cddis.2014.57. Abstract

* co-corresponding authors

Thedieck, K., Holzwarth, B., Prentzell, M.T., Boehlke, C., Kläsener, K., Ruf, S., Sonntag, A.G., Maerz, L, Grellscheid, S., Kremmer, E., Nitschke, R., Kuehn, E.W., Reth, M, Hall, M.N., and Baumeister, R. (2013) Inhibition of mTORC1 by Astrin and  stress granules prevents apoptosis  in cancer cells. Cell, 154, 859-874. Abstract

Runkel ED, Liu S, Baumeister R*, Schulze E (2013) Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response. PLoS Genet 9(3): e1003346. doi:10.1371/journal.pgen.1003346 Abstract

*corresponding author

Qi, W., Huang, X., Neumann-Haefelin, E., Schulze, E., and Baumeister, R. (2012) Cell-nonautonomous Signaling of FOXO/DAF-16 to the Stem Cells of C. elegans, PLoS Genetics, 8, e1002836. Abstract

Fatouros, C., Pir, G.P., Biernat, J., Koushika, S.P., Mandelkow, E., Mandelkow, E., Schmidt, E., Baumeister, R. (2012) Inhibition of Tau aggregation in a novel C. elegans model of Tauopathy mitigates proteotoxicity, Human Mol. Genet. 21, 3587-3603. Abstract

Dalle Pezze P, Sonntag AG, Thien A, Prentzell MT, Gödel M, Fischer S,
Neumann-Haefelin E, Huber TB, Baumeister R, Shanley DP, Thedieck K. (2012)  A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation. Science Signal. 2012 5, ra25. Abstract

Liu, S., Schulze, E., and Baumeister, R. (2012). Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans. PLoS One. 2012;7(3):e32360. Epub 2012 Mar 20. PMID:22448218. Abstract

Rizzini L, Favory JJ, Cloix C, Faggionato D, O'Hara A, Kaiserli E, Baumeister R, Schäfer E, Nagy F, Jenkins GI, Ulm R. (2011) Perception of UV-B by the Arabidopsis UVR8 protein. SCIENCE. 2011 Apr 1;332(6025):103-6. Abstract

Recent Patent application
Thedieck, K., Holzwarth, B., Baumeister, R. Modulators of the interaction of astrin and raptor, and uses thereof in cancer therapy
11.01.2013 - EP Anmeldung Nr. 13 151 022.4
13.01.2014 - PCT Anmeldung Nr. PCT/EP2014/050460

SGBM PhD students

SGBM PhD students:



Track 1:
Eva Runkel (06/2008 - 07/2013)

Tamara Prentzell (04/2012 - 05/2018)

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