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Leena Bruckner-Tuderman Profile Page
Leena Bruckner-Tuderman


Lab: Prof. Dr. Leena Bruckner-Tuderman
Department: Department of Dermatology
University Medical Center
Phone: 270 67160
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster : Member
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: Genetic and molecular basis of human skin diseases and the molecular mechanisms leading to clinical symptoms. The ultimate goal is to develop novel, biologically valid therapeutic strategies.


Education & Training: 1971-1976: Study of Medicine/Expt. Medicine(M.D.), University of Oulu, Finland
1974-1977: M.D.,PhD Program, University of Oulu, Finland
1987: Board Exam. Dermatology and Priv. Doc., University of Zürich, Switzerland
1995: Board Exam in the EU, University of Münster, Germany
Employment & Experience: 1980-1983 Postdoctoral Research Fellow in Structural Biology; Biocenter, University Basel, Switzerland
1984-1993 Resident & Senior staff member, Dermatology, University of Zürich
1993-2003 Professor / Senior staff member, Dermatology, University of Münster
2003-present Professor (C4) in Dermatology, University of Freiburg
2007 – present Fellow in Freiburg Institute for Advanced Studies (FRIAS), Director of School “LifeNet”
Scientific Activities: 1996-2002 Board member, Secretary-General & President, European Society for Dermatological Research
2000-2003 Board member, International Scociety for Matrix Biology
2002 Chair, Gordon Research Conference for Basement Membranes
2003-present Coordinator, National Competence Network “Epidermolysis bullosa”
2004-present Member of the Study Section IV in the “Collegium Medicine”, German Research Foundation DFG; Chair 2004-2008
2005-2009 Vice Chair of the Scientific Council for Medical Research of the Federal Ministry for Education and Research (BMBF)
2008-2011 Coordinator “International Kindler Syndrome Network – Kindlernet”
2009 Chair, Gordon Research Conference for Collagens
2010-present Member of the Board of the DFG Collaborative Research Center CRC850 “Control of cell motility in morphogenesis, cancer invasion and metastasis”, Freiburg
2011-present Chair, Medical and Scientific Advisory Panel, Debra International


Honors and Awards:

1990-1994: SCORE-Fellowship of Swiss National Science Foundation
1992: Cloetta-Prize of the Prof. Dr. Max Cloetta Foundation, Zürich
1993: Friedrich Götz Prize, University of Zürich
1994-1999: Heisenberg Fellowship, German Research Council (DFG)
1998: Visiting Professor, University of Hong Kong
2000-2001: Visiting Professor in Dermatology, Harvard Medical School
2001: Honorary Member of the Hungarian Dermatological Society
2002: US patent 60/309,158 Collagen XXII, a novel human collagen and
uses thereof
2003: Corresponding Member of the Swiss Society for Dermatology
2007: Member of the German Academy of Sciences Leopoldina
2008: Rudi Cormane Lecturer of the European Society for Dermatological Research
2009: Eva Luise Köhler Research Price 2009 for Rare Diseases
2010: Member of the Heidelberg Akademie der Wissenschaften


Selected Publications:

RhoA activation by CNFy restores cell-cell adhesion of kindlin 2-deficient keratinocytes skin equivalents. He Y, Sonnenwald T, Sprenger A, Hansen U, Fritsch A, Bruckner-Tuderman L, Schmidt G, Has C. J Pathol,  2014 Mar 10. doi: 10.1002/path.4350. Abstract

Collagen VII plays a dual role in wound healing. Nyström A, Velati D, Mittapalli VR, Kern JS, Fritsch A, Bruckner-Tuderman L (2013). J Clin Invest 123, 3498 – 3509.  Abstract

Global remodeling of cellular microenvironment due to loss of collagen VII. Küttner V, Mack C, Rigbolt KTG, Kern JS, Schilling O, Busch H, Bruckner-Tuderman L, Dengjel J (2013). Mol Syst Biol, Apr 16;9:657. doi: 10.1038/msb.2013.17. Abstract

Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization. Sprenger A, Weber S, Zarei M, Engelke R, Nascimento JM, Gretzmeier C, Hilpert M, Boerries M, Has C, Busch H, Bruckner-Tuderman L, Dengjel J (2013). Mol Cell Proteomics. 12: 2509-21. Abstract

Integrin a3 mutations with kidney, lung and skin disease. Has C*, Spartà G*, Kiritsi D*, Weibel L, Moeller A, Vega-Warner V, Waters A, He Y, Anikster Y, Esser P, Straub BK, Hausser I, Bockenhauer D, Dekel B, Hildebrandt F, Bruckner-Tuderman L§, Laube GF§ (2013). New Engl J Med 366, 1508-1514. Abstract
(*, §, equal contribution)

Revertant mosaicism in a human skin fragility disorder results from slippedmispairing and mitotic recombination. Kiritsi D, He Y, Pasmooij AMG, Onder M, Happle R, Jonkman M, Bruckner-Tuderman L, Has C (2012). J Clin Invest 122,1742-1746. Abstract

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. Franzke CW, Cobzaru C, Triantafyllopoulou A, Loeffek S,Horiuchi K, Threadgill DW, Kurz T, Bruckner-Tuderman L, Blobel CP (2012). J Ex Med 209,1105-19. Abstract

The epidermal basement membrane is a composite of separate laminin- and collagen IV-containing networks connected by aggregated perlecan, but not by nidogens. Behrens D, Villone D, Koch M, Brunner G, Sorokin L, Robenek H, Bruckner-Tuderman L, Bruckner P, Hansen U (2012). J Biol Chem, 287, 18700-9. Abstract

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons. Chiang LY, Poole K, Oliveira BE, Duarte N, Sierra YA, Bruckner-Tuderman L, Koch M, Hu J, Lewin GR (2011). Nat Neurosci 14, 993-1000. Abstract

A hypomorphic mouse model for dystrophic epidermolysis bullosa reveals disease mechanisms and responds to fibroblast therapy. Fritsch A, Loeckermann S, Kern JS, Braun A, Bösl MR, Bley T, Schumann H, von Elverfeldt D, Paul D, Erlacher M, Berens von Rautenfeld D, Hausser I, Fässler R, Bruckner-Tuderman L (2008). J Clin Invest 118, 1669-1679. Abstract

SGBM PhD students

SGBM PhD students:


Track 1
Johannes Kern (09/2007 - 02/2010)

Track 2
Chiara Pazzagli (08/2011 - 11/2014)

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