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Klaus Aktories Profile Page
Klaus Aktories


Lab: Prof. Dr. Klaus Aktories
Department: Institute of Experimental and
Clinical Pharmacology and Toxicology
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Lab homepage:
BIOSS Excellence Cluster: Member
PhD positions available: NO
Research Area: Synthetic Biology and Signalling
Research Interests: Pharmacology, toxicology and cell biology of bacterial toxins; Signal transduction of small GTPases ; Role of the Rho GTPases in neuronal differentiation; Structural and functional analysis of voltage-dependent calcium channels


Education & Training: 1969-1972: Study of Pharmacy, University Frankfurt, Germany
1971-1977: Study of Medicine, University Frankfurt, Germany
1977: Dr med. (M.D.), Faculty of Medicine, University Frankfurt, Germany
1981: Dr. rer. nat. (Ph.D.), Pharmacology, Faculty of Natural Science, University Heidelberg, Germany
1983: Habilitation, Pharmacology, Faculty of Theoretical Medicine, University Heidelberg, Germany
Employment & Experience: 1978-1984: Research Associate, Pharmacology, University of Heidelberg (Group of Prof. Dr. G. Schultz)
1985-1989: Associate Professor (C2), Pharmacology, University of Gießen
1989-1991: Associate Professor (C3), Pharmacology, University of Essen
1991-1994: Full Professor (C4), Pharmacology and Toxicology, University of the Saarland
1995-present: Full Professor (C4), Department 1 of the Institute of Experimental and Clinical Pharmacology and Toxicology, University Freiburg
Scientific Activities: Membership in Editorial Boards (past and present):
European Journal of Pharmacology, Naunyn-Schmiedeberg?s Archives of Pharmacology , Medical Microbiology and Immunology, Toxicon, Infection and Immunity, International Journal of Medical Microbiology


Honors and Awards:

Coordinator of DFG Priority Programm (Schwerpunktprogramm) SPP1150 Feldberg-Foundation Award 2005
Member of The German Academy of Natural Scientists Leopoldina (2003)


Selected Publications:
Lang,A.E., Schmidt,G., Schlosser,A., Hey,T.D., Larrinua,I.M., Sheets,J.J., Mannherz,H.-G., and Aktories,K. (2010). Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering. Science 327,1139-1142. Abstract

Schwan, C., Stecher, B., Tzivelekidis, T., van Ham, M., Rohde, M., Hardt, W.-D., Wehland, J., and Aktories, K. (2009). Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria. Plos Pathogens, doi:10.1371/journal.ppat.1000626 Abstract

Orth, J. H., Preuss, I, Fester, I, Schlosser, A, Wilson, B. A., and Aktories, K. (2009). Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation. Proc. Natl. Acad. Sci. USA 17,7179-7184 Abstract

Belyi, Y., Stahl, M., Sovkova, I., Kaden, P., Luy, B., Aktories, K. (2009) Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase LGT1-identification of LGT1 as a retaining glucosyltransferase. J. Biol. Chem., 284, 20167-20174. Abstract

Orth, J.H.C.; Fester, I.; Preuß, I.; Agnoletto, L.; Wilson, B.A.; Aktories, K. (2008): Activation of Gai and subsequent uncoupling of receptor-G ai signaling by Pasteurella multocida toxin. J. Biol. Chem. 283, 23288-23294 Abstract

Giesemann, T.; Guttenberg, G.; Aktories, K. (2008): Human alpha-defensins inhibit Clostridium difficile toxin B. Gastroenterology 134, 2049-2058 Abstract

Egerer, M.; Giesemann, T.; Jank, T.; Satchell, K.J.; Aktories, K. (2007): Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on a cysteine protease activity. J. Biol. Chem. 282, 25314-25321 Abstract

Belyi, Y., Niggeweg, R., Opitz, B., Vogelsgesang, M., Hippenstiel, S., Wilm, M., and Aktories, K. (2006) Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A. Proc. Natl. Acad. Sci. USA, 103,16953-16958. Abstract

Giesemann, T.; Jank, T.; Gerhard, R.; Maier, E.; Just, I.; Benz, R.; Aktories, K. (2006): Cholesterol-dependent pore formation of Clostridium difficile toxin A. J.Biol. Chem. 281, 10808-10815 Abstract

Pautsch, A., Vogelsgesang, M., Trankle, J., Herrmann, C., and Aktories, K. (2005) Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme. EMBO J 24, 3670-3680. Abstract


SGBM PhD students

SGBM PhD students:


Peter Njenga Ng'ang'a (October 2016-July 2020)

Julia Ebner (née Behr) (January 2015-March 2019)

Friederike Lehmann (January 2015-July 2018)

Björn Schorch (February 2012-March 2017)

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