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Contact
Lab: | Prof. Dr. Nikolaus Pfanner |
Department: | Institute of Biochemistry and Molecular Biology |
Phone: | 203 5223/5224 |
E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
Lab homepage: | www.biochemie.uni-freiburg.de/ag/pfanner |
BIOSS Excellence Cluster: | Member |
PhD positions available: | NO |
Research Area: | Protein Structure and Function |
Research Interests: | Targeting, translocation and folding of mitochondrial proteins |
CV
Education & Training: | 1978-1984: Study of Medicine, University of Munich, Germany 1985: Dr. med., University of Munich, Germany 1990: Habilitation, University of Munich, Germany |
Employment & Experience: | 1985-1986: Postdoctoral Fellow in Physiological Chemistry, University of Munich 1987-88 & 89-92: Junior Group Leader, University of Munich 1988-1989: Research Fellow in Molecular Biology, Princeton University, USA 1992-present: Full Professor and Chair of Biochemistry, University of Freiburg |
Scientific Activities: | 1995-2006 Coordinator of Collaborative Research Centre on “Cellular Functions of Dynamic Protein Interactions” Freiburg (SFB 388) 1996-2004 Elected DFG reviewer for Biochemistry 1996-2000 Chairman of DFG Study Section of Biological Chemistry & Biophysics 1999-2011 Member Advisory Board, Max Planck Research Unit in Halle 2001-2006 Member of DFG Senate Commission on Genetic Research 2002-2008 Chairman of Research Board of Medical Faculty Freiburg 2005-present Member Advisory Board, Max Planck Institute for Medical Research Heidelberg 2007-2009 Vice President of German Society for Biochemistry & Molec. Biology 2008-present Member of the Council of the University of Freiburg 2009-present Member Advisory Board, Max Planck Institute for Biophysics Frankfurt 2009-2011 President of German Society for Biochemistry & Molecular Biology Editorial Board Current Biology (1998-present), Journal of Biological Chemistry (1999- 2001), EMBO Journal (1999-present), EMBO Reports (2000-2010) |
Honors
Honors and Awards: | 1985: Summa cum laude, University of Munich |
Publications
Selected Publications: | Shiota, T., Imai, K., Qiu, J., Hewitt, V.L., Tan, K., Shen, H.H., Sakiyama, N., Fukasawa, Y., Hayat, S., Kamiya, M., Elofsson, A., Tomii, K., Horton, P., Wiedemann, N., Pfanner, N., Lithgow, T., and Endo, T. (2015). Molecular architecture of the active mitochondrial protein gate. Science 349, 1544-1548. Abstract Harbauer, A.B., Opalinska, M., Gerbeth, C., Herman, J.S., Rao, S., Schönfisch, B., Guiard, B., Schmidt, O., Pfanner, N.*, and Meisinger, C.* (2014). Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science 346, 1109-1113. Abstract Qiu, J., Wenz, L.S., Zerbes, R.M., Oeljeklaus, S., Bohnert, M., Stroud, D.A., Wirth, C., Ellenrieder, L., Thornton, N., Kutik, S., Wiese, S., Schulze-Specking, A., Zufall, N., Chacinska, A., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N.*, Wiedemann, N.*, and Becker, T. (2013). Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell 154, 596-608. Abstract Schmidt, O., Harbauer, A.B., Rao, S., Eyrich, B., Zahedi, R.P., Stojanovski, D., Schönfisch, B., Guiard, B., Sickmann, A., Pfanner, N.*, and Meisinger, C.* (2011). Regulation of mitochondrial protein import by cytosolic kinases. Cell 144, 227-239. Abstract Chacinska, A., Koehler, C.M., Milenkovic, D., Lithgow, T., and Pfanner, N.* (2009). Importing mitochondrial proteins: machineries and mechanisms. Cell 138, 628-644. Abstract Vögtle, F.-N., Wortelkamp, S., Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A.*, Pfanner, N.*, Meisinger, C. (2009). Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell 139, 428-439. Abstract Kutik, S., Stojanovski, D., Becker, L., Becker, T., Meinecke, M., Krüger, V., Prinz, C., Meisinger, C., Guiard, B., Wagner, R., Pfanner, N.*, Wiedemann, N. (2008) Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell 132, 1011-1024. Abstract Meinecke, M., Wagner, R.*, Kovermann, P., Guiard, B., Mick, D.U., Hutu, D.P., Voos, W., Truscott, K.N., Chacinska, A., Pfanner, N.*, Rehling, P. (2006) Tim50 maintains the permeability barrier of the mitochondrial inner membrane. Science 312, 1523-1526. Abstract Chacinska, A., Lind, M., Frazier, A.E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Truscott, K.N., Guiard, B., Pfanner, N.*, Rehling, P.* (2005) Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-829. Abstract Rehling, P., Model, K., Brandner, K., Kovermann, P., Sickmann, A., Meyer, H., Kühlbrandt, W., Wagner, R., Truscott, K.N., Pfanner, N.* (2003) Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science 299, 1747-1751. Abstract |
SGBM PhD students
SGBM PhD students: | Alumni Track 1: |