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Michael Reth Profile Page
Michael Reth


Lab: Prof. Dr. Michael Reth
Department: Department of Molecular Immunology
Max-Planck Institute of Immunobiology
Faculty of Biology
Phone: 5108 421
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster : Scientific Director of BIOSS
PhD positions available: NO
Research Area: Synthetic Biology and Signalling
Research Interests: Organisation and regulation of intracellular signalling pathways in normal and diseased lymphocytes:Rebuilding the signaling pathways from the B cell antigen receptor, Cre/loxP technique for the B cell specific induction or deletion of genes in the mouse


Education & Training: 1977: Diploma in Biology, University Cologne, Germany
1977-81 Doctoral studies, University of Cologne, Institute of Genetics
Employment & Experience: 1971-77 Biology diploma, University of Cologne
1982-85 Postdoctoral fellowship (DFG), Columbia University
1985-88 Group leader, Institute of Genetics, University of Cologne
1988 Habilitation in Genetics, University of Cologne
1989-96 Associate Professor, Max-Planck Institute for Immunobiology, Freiburg
1996-present Full Professor in Molecular Immunology, Albert-Ludwigs-University Freiburg, Germany
2007-present Scientific director of the Center for Biological Signalling Studies (BIOSS) funded by the excellence program of the German Government
Scientific Activities: 1990-present Transmitting Editor International Immunology
1992-2002 Editorial Board, European Journal of Immunology
2003-present Editorial Board, Annual Review of Immunology
2005-present Member of the advisory board for the immune disease institute (IDI), Harvard University
2008 Honorary member of the American Association of Immunologists (AAI)


Honors and Awards:

2014                           Paul Ehrlich and Ludwig Darmstaedter Prize
2012                           ERC Advanced Grant
2009                           EFIS-Schering-Plough European Immunology Prize
2006                           Elected member of the Leopoldina, German National Academy of Sciences
2005-present              Member of the Advisory Board of the of the IDI Institute, Harvard University, USA
1995                           Gottfried-Wilhelm-Leibniz Prize of the DFG
1995                           Elected member of EMBO
1988                           Heinz-Maier-Leibnitz Prize of the DFG


1990     Exon trapping: methods and vectors for selectively cloning of exons. P 40 21 458.3-41 filed on July 5, 1990



Selected Publications:

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman, CL, Melnick A, Mignon LL, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Clifford AL, Müschen M (2015). Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature doi10.1038/nature14231

Hobeika E, Levit-Zerdoun E, Anastasopoulou V, Pohlmeyer R, Altmeier S, Alsadeq A, Dobenecker MW, Pelanda R, Reth M. (2015). CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J. pii: e201489732. [Epub ahead of print] Abstract

Kläsener K, Maity PC, Hobeika E, Yang J, Reth M. (2014). B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk. Elife 3: e02069. Abstract

Alsadeq A, Hobeika E, Medgyesi D, Kläsener K, Reth M. (2014). The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling. J Immunol 193(1):268-276. Abstract

Medgyesi D, Hobeika E, Biesen R, Kollert F, Taddeo A, Voll R, Hiepe F and Reth M. (2014). The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 signaling and of B cell autoimmunity. J Exp Med 211(3): 427-440. Abstract

Reth M. Matching cellular dimensions with molecular sizes. Nat Immunol. 2013 Aug;14(8):765-7. doi: 10.1038/ni.2621. Abstract

Reth, M. Pillars of Immunology article. (2014). J Immunol 192(9):4015-4016. Reprint of “Antigen receptor tail clue”. Nature (1989).338:383-384. Abstract

Yang, J., and Reth, M. (2010). Oligomeric organization of the B-cell antigen receptor on resting cells. Nature 467(7314): 465-469. Abstract

Jumaa, H., Bossaller, L., Portugal, K., Storch, B., Lotz, M., Flemming, A., Schrappe, M., Postila, V., Riikonen, P., Pelkonen, J., Niemeyer, CM, Reth, M. (2003). Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. Nature 423, 452-456. Abstract

Hombach, J., Tsubata, T., Leclercq, L., Stappert, H, Reth, M. (1990). Molecular components of the B-cell antigen receptor complex of the IgM class. Nature 343: 760-762. Reprinted as Pillars of Immunology in J Immunol (2009) 183: 1505-1507. Abstract

SGBM PhD students

SGBM PhD students:

Track 2:
Melanie Sieder (since October 2017)


Track 1:

Ameera Alsadeq (06/2008 - 09/2012)

Elmar Dolezal (04/2009 - 10/2013)

Kathrin Brenker (1/2013 - 2/2018)

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