![]() |
Contact
Lab: | Prof. Dr. Wolfgang Schamel |
Department: | Faculty of Biology and Center of Chronic Immunodeficiency |
Phone: | 203 67511 |
E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
Lab homepage: | www.bioss.uni-freiburg.de/schamel-group/home/ |
BIOSS Excellence Cluster: | Associated member |
PhD positions available: | YES |
Research Area: | Immunology and Virology |
Research Interests: | define the protein complexes that change in time and space within the signaling cascades of the antigen TCR |
CV
Education & Training: | 1994: Diploma in Biochemistry, Freie Universität Berlin, Germany 1999: Dr. rer. nat., Albert-Ludwigs-University Freiburg, Germany |
Employment & Experience: | 1993-1994: Diploma thesis in Cell Biology, Weizmann Institute of Science, Rehovot, Israel 1995-1999: PhD thesis in Molecular Immunology, Max Planck Institute for Immunobiology, Freiburg, Germany 2000-2002: Postdoc at the Centro de Biologia Molecular 'Severo Ochoa', CSIC, Madrid, Spain 2002-2008: Junior group leader through the Emmy Noether Program, Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany 2008-2010 Group at the Max-Planck-Institute for Immunology and Epigenetics, Freiburg 2010-present: Professor in Immunology, Institute of Biology III, Faculty of Biology, Albert-Ludwig University Freiburg, Center of Chronic Immunodeficiency and Max-Planck Institute of Immunobiology and Epigenetics, Department of Molecular Immunology, Freiburg |
Scientific Activities: | Editorial board member of "Cell Communication and Signaling" Guest editor of "Frontiers in Biosciences" 2005-present: Member, German Society for Immunology (DGfI) 2005-present: Member, German Signal Transduction Society (GST) 2005-2013: Member of the SFB620 2008-2013: Coordinator of the large integrative EU FP7 project SYBILLA (Systems biology of T-cell activation) |
Honors
Honors and Awards: | 2000: Hans Spemann-Prize of the Albert-Ludwigs-University Freiburg
Patents: Alarcón B, Gil D, Schamel WWA, Sánchez-Madrid F und Montoya M. Nueva estrategia moduladora de la activación de los linfocitos T basada en la regulación de la interacción CD3ε-Nck. Spanish Patent No. 200200157, January 24, 2002. |
Publications
Selected Publications: | Schamel WW, Alarcon B, Höfer T, Minguet S. (2017) The Allostery Model of TCR Regulation. J Immunol. 198: 47-52. Abstract Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi S, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WW. (2014) The CD3 conformational change in the γδ T-cell receptor is not triggered by antigens, but can be enforced to enhance tumor killing. Cell Rep. 2014 Jun 12;7(5):1704-15. Abstract Schamel WWA, Arechaga I, Risueno RM, van Santen H, Cabezas P, Risco C, Valpuesta JM and Alarcón B. (2005). Coexistence of multivalent and monovalent TCRs explains high sen-sitivity and wide range of response. J Exp Med 202, 493-503. Abstract |
SGBM PhD students
SGBM PhD students: | Trang Nguyen (since January 2022) Vincent Idstein (since April 2020) Claudia Juraske (since January 2020)
Alumni Track 1: Katharina Beck (04/2009 - 11/2013) Sascha Yousefi (12/2012-10/2018) Anna Morath (1/2014-2/2019)
Track 2: |