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Wolfgang Schamel Profile Page
Wolfgang Schamel


Lab: Prof. Dr. Wolfgang Schamel
Department: Faculty of Biology and Center of Chronic Immunodeficiency
Phone: 203 67511
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster : Associated member
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: define the protein complexes that change in time and space within the signaling cascades of the antigen TCR


Education & Training: 1994: Diploma in Biochemistry, Freie Universität Berlin, Germany
1999: Dr. rer. nat., Albert-Ludwigs-University Freiburg, Germany
Employment & Experience: 1993-1994: Diploma thesis in Cell Biology, Weizmann Institute of Science,
Rehovot, Israel
1995-1999: PhD thesis in Molecular Immunology, Max Planck Institute for
Immunobiology, Freiburg, Germany
2000-2002: Postdoc at the Centro de Biologia Molecular 'Severo Ochoa', CSIC,
Madrid, Spain
2002-2008: Junior group leader through the Emmy Noether Program, Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany
2008-2010 Group at the Max-Planck-Institute for Immunology and Epigenetics, Freiburg
2010-present: Professor in Immunology, Institute of Biology III, Faculty of Biology, Albert-Ludwig University Freiburg, Center of Chronic Immunodeficiency and Max-Planck Institute of Immunobiology and Epigenetics, Department of Molecular Immunology, Freiburg
Scientific Activities: Editorial board member of "Cell Communication and Signaling"
Guest editor of "Frontiers in Biosciences"
2005-present: Member, German Society for Immunology (DGfI)
2005-present: Member, German Signal Transduction Society (GST)
2005-2013: Member of the SFB620
2008-2013: Coordinator of the large integrative EU FP7 project SYBILLA (Systems biology of T-cell activation)


Honors and Awards:

2000: Hans Spemann-Prize of the Albert-Ludwigs-University Freiburg
2000-2002: Scholarship, Marie Curie Individual Fellowship of the EU
2002-2008: Scholarship, Emmy Noether Program of the DFG
2005: STS-Prize of the Signaltransduction Society



Alarcón B, Gil D, Schamel WWA, Sánchez-Madrid F und Montoya M. Nueva estrategia moduladora de la activación de los linfocitos T basada en la regulación de la interacción CD3ε-Nck. Spanish Patent No. 200200157, January 24, 2002.

Schamel WWA und Reth M. Generelle Proteindetektion mittels Biotinilierung im Gel und anschließendem Western Blotting. German Patent No. 19913940.7.The German Patent and Trademark Office, March 20, 1999.


Selected Publications:

Schamel WW, Alarcon B, Höfer T, Minguet S. (2017) The Allostery Model of TCR Regulation. J Immunol. 198: 47-52. Abstract

Wang F, Beck-García K, Zorzin C, Schamel WW, Davis MM. (2016) Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nat Immunol. 17: 844-50. Abstract

Swamy M, Beck-Garcia K, Beck-Garcia E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnár E, Schulze AK, Blanco R, Borroto A, Martín-Blanco N, Alarcon B, Höfer T, Minguet S, Schamel WW. (2016) A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation. Immunity. 44:1091-101. Abstract

Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW. (2015) Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. J Exp Med. 212:1693-708. Abstract

Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi S, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WW. (2014) The CD3 conformational change in the γδ T-cell receptor is not triggered by antigens, but can be enforced to enhance tumor killing. Cell Rep. 2014 Jun 12;7(5):1704-15. Abstract

Deswal S, Meyer A, Fiala GJ, Eisenhardt AE, Schmitt LC, Salek M, Brummer T, Acuto O, Schamel WW. (2013) Kidins220/ARMS Associates with B-Raf and the TCR, Promoting Sustained Erk Signaling in T Cells. J Immunol 190, 1927-1935. Abstract

Schamel WW, Alarcón B. (2013) Organization of the resting TCR in nanoscale oligomers. Immunol Rev 251, 13-20. Abstract

Fiala GJ, Kaschek D, Blumenthal B, Reth M, Timmer J, Schamel WW. (2013) Pre-clustering of the B cell antigen receptor demonstrated by mathematically extended electron microscopy. Front Immunol. 4:427 eCollection 2013 Abstract

Kumar R, Ferez M, Swamy M, Arechaga I, Rejas MT, Valpuesta JM, Schamel WW, Alarcon B, van Santen HM. (2011) Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes.
Immunity 35, 375-387. Abstract

Schamel WWA, Arechaga I, Risueno RM, van Santen H, Cabezas P, Risco C, Valpuesta JM and Alarcón B. (2005). Coexistence of multivalent and monovalent TCRs explains high sen-sitivity and wide range of response. J Exp Med 202, 493-503. Abstract

SGBM PhD students

SGBM PhD students:

Track 1:

Anna Morath (since January 2014)



Track 1:
Sumit Deswal (07/2007 - 02/2012)

Katharina Beck (04/2009 - 11/2013)

Sascha Yousefi (12/2012-10/2018)

Track 2:
Gina Fiala (06/2009 - 01/2015)

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