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Peter Staeheli Profile Page
Peter Staeheli


Lab: Prof. Dr. Peter Stäheli
Department: Institute of Virology
Department for Medical Microbiology and Hygiene
Phone: 203 6579
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: NO
Research Area: Immunology and Virology
Research Interests: Mechanisms of Borna disease virus-induced immunopathogenesis in the CNS, genetic manipulation of Bornaviruses


Education & Training: 1973-1977: Diploma in Microbiology, ETH Zürich, Switzerland
1977-1981: Dr. sc. nat., Microbiology, ETH Zürich, Switzerland
1990: PD, Virology, University of Zürich, Switzerland
Employment & Experience: 1981-1985: Postdoctoral Fellow, Dept. Virology, University of Zürich
1985-1987: Postdoctoral Fellow, Scripps Research Foundation, La Jolla, CA
1987-1990: Research Group Leader, Dept. Virology, University of Zürich
1990-present: C3-Professor in Virology, Albert-Ludwigs-University Freiburg, Germany
Scientific Activities: MEMBERSHIPS
Gesellschaft für Virologie
American Society for Virology
American Society for Microbiology
Society of General Microbiology
International Society for Interferon and Cytokine Research

2001-2007 Journal of Interferon and Cytokine Research
2007-2011 Journal of General Virology

2004-2007 Elected member of the DFG-Fachkolleg „Microbiology, Virology & Immunology“
2007-2011 Re-elected member of the DFG-Fachkolleg „Microbiology, Virology & Immunology“


Honors and Awards:

1992     European Award for Interferon Research, Gesellschaft der Freunde der
Medizinischen Hochschule Hannover, Germany
1992     Award and Gold Medal from the Stiftung für Wissenschaftliche
Forschung, University of Zürich, Switzerland
2009     Milstein Award from the International Society for Interferon and Cytokine Research (ISICR)


Selected Publications:

Mahlakõiv, T., Hernandez, P., Gronke, K., Diefenbach, A., & P. Staeheli. Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infections. PLoS Pathogens. Abstract

Hernández, P., Mahlakõiv, T., Nguyen, N., Guendel, F., Ryffel, B., Hoelscher, C., Dumoutier, L., Renauld, J.-C., Staeheli, P., & A. Diefenbach. Interleukin-22 produced by group 3 innate lymphoid cells restricts viral replication in intestinal epithelial cells. Nature Immunol. (accepted March 30, 2015)

Crotta, S., Davidson, S., Mahlakõiv, T., Desmet, C.J., Buckwalter, M.R., Albert, M.L., Staeheli, P., & A. Wack. Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia. PLoS Pathogens 9/11: e1003773 (2013). Abstract

Ganal, S.C., Sanos, S.L., Kallfass, C., Oberle, K., Johner, C., Kirschnig, C., Lienenklaus, S., Weiss, S., Staeheli, P., Aichele, P., & A. Diefenbach. Priming of natural killer cells by non-mucosal mononuclear phagocytes requires instructive signals from commensal microbiota. Immunity 37: 171-186 (2012). Abstract

Pott, J., Mahlakoiv, T., Mordstein, M., Duerr, C.U., Michiels, T., Stockinger, S., Staeheli, P., & M.W. Hornef. Interferon-lambda determines the intestinal epithelial antiviral host defense. Proc. Natl. Acad. Sci. USA 108: 7944-7949 (2011). Abstract

Lienenklaus, S., Cornitescu, M., Zietara, N., Gekara, N., Jablonska, J., Edenhofer, F., Bruder, K., Hafner, M., Staeheli, P. & S. Weiss. Novel reporter mouse reveals constitutive and inflammatory expression of IFN-β in vivo. J. Immunol. 183: 3229-3236 (2009). Abstract

Mordstein, M., Kochs, G., Dumoutier, L., Renauld, J., Paludan, S.R., Klucher, K. & P. Staeheli. Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. PLoS Pathogens 4/9: e1000151 (2008). Abstract

Sommereyns, C., Paul, S., Staeheli, P. & T. Michiels. IFN-lambda is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathogens 4/3: e1000017 (2008). Abstract

Grimm, D., Staeheli, P., Hufbauer, M., Koerner, I., Martínez-Sobrido, L., Solórzano, A., García-Sastre, A., Haller, O. & G. Kochs. Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene. Proc. Natl. Acad. Sci. USA 104: 6806-6811 (2007). Abstract

Tumpey, T., Szretter, K. J., van Hoeven, N., Katz, J.M., Kochs, G., Haller, O., García-Sastre, A. & P. Staeheli. The Mx1 gene protects mice against pandemic 1918 and highly lethal human H5N1 influenza viruses. J. Virol. 81: 10818-10821 (2007). Abstract

SGBM PhD students

SGBM PhD students:

Track 2:

Daniel Schnepf (since June 2016)



Track 1:
Tanel Mahlakoiv (04/2010 - 01/2014)


Track 2:
Markus Mordstein (08/2007 - 12/2010)

Cindy Nürnberger (07/2011 - 04/2016)

Ebrahim Hassan (01/2015 - 07/2018)

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