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Contact
| Lab: | Prof. Dr. Robert Thimme |
| Department: | Department of Medicine University Medical Center |
| Phone: | 270 32800 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | www.uniklinik-freiburg.de/gastro/live/forschung/thimme_en.html |
| PhD positions available: | YES |
| Research Area: | Immunology and Virology |
| Research Interests: | Identification and characterization of virus-specific CD4+ and CD8+ T cell responses during HBV and HCV infection ( intrahepatic T cell responses and mechanisms of viral persistence) |
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| Education & Training: | 1989-1996: MD, Medicine, Free University of Berlin and Albert-Ludwigs-University Freiburg, Germany |
| Employment & Experience: | 1993-1995: Doctoral thesis in the Department of Virology (Head: Prof. Otto Haller), University of Freiburg, honor: summa cum laude 1995: Clinical Observer at the Memorial Sloan Kettering Cancer Center (Head: Prof. John Mendelsohn), New York (USA) 1996-1998: MD in the Department of Medicine II (Head: Prof. Hubert E. Blum), University of Freiburg 1998-2001: Research Associate at the Scripps Research Institute (Head: Prof. Francis V. Chisari) 2002-present: Junior Group leader in the Emmy Noether Programme of the Deutsche Forschungsgemeinschaft (DFG), Department of Medicine II (Head: Prof. Hubert E. Blum), University of Freiburg 2004-present: Junior Professor for hepatitisvirusinfections in the Department of Medicine II (Head: Prof. Hubert E. Blum), University of Freiburg 2009-present W2/W3-Heisenberg-Professor for Hepatology |
| Scientific Activities: | 2005-present Editorial Board, Journal of Clinical Investigation, Gastroenterology, Journal of Infectious Diseases, World Journal of Gastroenterology, Journal of Hepatology, Langenbeck´s Archives of Surgery, Frontiers in Virology 1999-present Member, American Association for the Study of Liver Disease, European Society of Clinical Virology, German Association for Internal Medicine, German Association for the Study of Liver Diseases, The European Association for the Study of the Liver, German Association for Gastroenterology 2000-present regular reviewer of Nature Medicine, Journal of Clinical Investigation, Journal of Virology, Journal of Immunology, Gastroenterology, Hepatology, European Journal of Immunology, Journal of Infectious Diseases, Journal of Clinical Microbiology, The Lancet, Blood, Liver Transplantation, Journal of General Virology, Journal of Interferon and Cytokine Research, Vaccine, Liver International, International Journal of Virology, Deutsche Medizinische Wochenschrift, Zeitschrift für Gastroenterologie 2000-present regular reviewer for Grant agencies DFG, Swiss National Science Foundation, Welcome Trust, INSERM, French National Cancer Institute, DAAD, Medical Research Council, Dutch Digestive Foundation 2006-2007 programme committee German Association for the study of liver diseases (GASL) 2009-present Scientific Secretary of the German Association for the Study of Liver diseases (GASL) |
Honors
| Honors and Awards: | 1994 Ludwig Heilmeyer Price of the University of Freiburg for best experimental doctoral thesis |
Publications
| Selected Publications: | Billerbeck E, Kang YH, Walker L, Lockstone H, Grafmueller S, Fleming V, Flint J, Willberg CB, Bengsch B, Seigel B, Ramamurthy N, Zitzmann N, Barnes EJ, Thevanayagam J, Bhagwanani A, Leslie A, Oo YH, Kollnberger S, Bowness P, Drognitz O, Adams DH, Blum HE, Thimme R, Klenerman P. (2010) Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc Natl Acad Sci U S A., 107(7):3006-11. Abstract Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum HE, Pircher H, Thimme R. (2010) Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog. 10;6(6):e1000947 Abstract Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. (2010) Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope. Hepatology, 51(1):54-62. Abstract Neumann-Haefelin C, Timm J, Spangenberg HC, Wischnowski N, Nazarova N, Kersting N, Roggendorf M, Allen TM, Blum HE, Thimme R. (2008) Virological and immunological determinants of intrahepatic virus-specific CD8+ T cell failure in chronic hepatitis C virus infection. Hepatology, 47 (6): 1824-36.Abstract Billerbeck E, Blum HE, Thimme R. (2007) Parallel expansion of human virus-specific FoxP3- effector memory and de novo-generated FoxP3+ regulatory CD8+ T cells upon antigen recognition in vitro. J Immunol 179, 1039-48. Abstract
Bengsch B, Spangenberg HC, Kersting N, Neumann-Haefelin C, Panther E, von Weizsäcker F, Blum HE, Pircher H, Thimme R. (2007) Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol 81, 945-53. Abstract |
SGBM PhD students
| SGBM PhD students: | Track 2: Alumni: Track 2: |



