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Contact
| Lab: | Prof. Dr. Thomas Reinheckel |
| Department: | Institute for Molecular Medicine and Cell Research University Medical Center |
| Address: | Stefan-Meier-Str. 17 79104 Freiburg |
| Phone: | 49 761 203 9606 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | www.mol-med.uni-freiburg.de/mom-en/reinheckel |
| BIOSS Excellence Cluster: | Associated member |
| PhD positions available: | YES |
| Research Area: | Molecular Medicine |
| Research Interests: | In vivo functions of proteases |
CV
| Education & Training: | 2007: Habilitation in Molecular Medicine, University of Freiburg 1997: Dissertation, Pathological Biochemistry, University of Magdeburg 1996: Medical state examination 1996: Studies of Medicine, Albert Einstein College of Medicine, NYC 1993 – 1994: Academic Year, Dept. Biochemistry and Molecular Biology; Albany N.Y 1989 – 1996: Study of Medicine, University Magdeburg |
| Employment & Experience: | 2014-present President of the International Proteolysis Society 2013-present Professor (W3) of Molecular Medicine / Cellular Pathomechanisms, Institute of Molecular Medicine and Cell Research Freiburg 2010-present Board Member of SFB 850 - Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis, Freiburg 2007-present Associate Member Centre for Biological Signalling Studies – BIOSS - (Cluster of Excellence), Freiburg 2007-present Principal Investigator Comprehensive Cancer Center Freiburg Research Program 2006-present Principal Investigator Spemann Graduate School for Biology and Medicine (SGBM), Freiburg 2013-2014 Council Member and Vice President of the International Proteolysis Society 2002-2012 Group leader; Institute of Molecular Medicine and Cell Research Freiburg 1999-2002 Postdoc; Institute of Molecular Medicine and Cell Research Freiburg 1997-1999 Internship / Residency, Dept. of General Surgery, University Hospital Magdeburg |
| Scientific Activities: | 1994-present: German Society for Biochemistry and Molecular Biology 2004-present: International Proteolysis Society (IPS) |
Honors
| Honors and Awards: | 2007 Habilitation award by the Fonds of Chemical Industry 1993/1994 Fellowship Biomedical Sciences Exchange Program between North America and Europe 1991-1996 Fellowship der Hans-Böckler-Foundation |
Publications
| Selected Publications: | Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T. (2014) Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nat Commun. 5:4931. Abstract Bengsch F, Buck A, Günther SC, Seiz JR, Tacke M, Pfeifer D, von Elverfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T. (2014) Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene 33(36):4474-84. Abstract Müller S, Faulhaber A, Sieber C, Pfeifer D, Hochberg T, Gansz M, Deshmukh SD, Dauth S, Brix K, Saftig P, Peters C, Henneke P, Reinheckel T. (2014) The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction. FASEB J. 28(1):162-75. Abstract Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA. Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes Dev. 2014 Oct 1;28(19):2134-50. Abstract Dennemärker J, Lohmüller T, Mayerle J, Tacke M, Lerch MM, Coussens LM, Peters C, Reinheckel T. (2010) Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis. Oncogene. 18;29(11):1611-21. Abstract Reiser J, Adair B, and Reinheckel T. (2010) Specialized roles for cysteine cathepsins in health and disease. J Clin Invest 120(10):3421-31. Abstract Sevenich, L., Schurigt, U., Sachse, K., Gajda, M., Werner, F., Müller, S., Vasiljeva, O., Schwinde, A., Klemm, N., Deussing, J., Peters, C., and Reinheckel, T. (2010) Synergistic anti-tumor effects of combined cathepsin B and cathepsin X/Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 107(6):2497-502. Abstract Halle, A., Hornung, V., Petzold, G.C., Stewart, C.R., Monks, B.G., Reinheckel, T., Fitzgerald, K.A., Latz, E., Moore, K.J., Golenbock, D.T. (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol. 9(8), 857-65. Abstract Vasiljeva, O., Papazoglou, A., Krüger, A., Brodoefel, H., Korovin, M., Deussing, J., Augustin, N., Nielsen, B.S., Almholt, K., Bogyo, M., Peters, C., Reinheckel, T.: (2006) Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res. 66, 5242-5250. Abstract Stypmann, J., Glaser, K., Roth, W., Tobin, D.J., Petermann, I., Matthias, R., Mönnig, G., Haverkamp, W., Breithardt, G., Schmahl, W., Peters, C., Reinheckel, T. (2002) Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc. Natl. Acad. Sci. U S A. 99, 6234-6239. Abstract |
SGBM PhD students
| SGBM PhD students: | Alumni Track 1: Alejandro Gomez Auli (04/2012 - 11/2016) Ursula Kern (07/2009 - 01/2014) Fee Bengsch (04/2009 - 06/2013) |
