Thorsten Friedrich

Thorsten Friedrich Profile Page

Contact

Lab:	Prof. Dr. Thorsten Friedrich
Department:	Institute of Biochemistry
Phone:	203 6060
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.biochem.uni-freiburg.de/index_en.htm
PhD positions available:	YES
Research Area:	Protein Structure and Function
Research Interests:	Mitochondria and bacteria respiratory complex I, the first complex of cell respiration

CV

Education & Training:	Education/Training 1981-1988: Study of Chemistry, University of Düsseldorf, Germany 1992: Dr. rer. nat., University of Düsseldorf, Germany
Employment & Experience:	1992 Visiting Research Fellow in Biophysics, Johnson Foundation, Philadelphia, USA 1993-94 Research Fellow in Biochemistry, Heinrich-Heine-University, Düsseldorf, Germany 1994 Research Fellow in Biophysics, Johnson Foundation, Philadelphia, USA 1994-2000 Research Fellow in Biochemistry, Heinrich-Heine-University, Düsseldorf, Germany 2000-2001 Assistant Professor in Biochemistry, Heinrich-Heine-University, Düsseldorf, Germany 2001-present Professor in Biochemistry, Albert-Ludwigs-University Freiburg, Germany
Scientific Activities:	1993-present Referee for the ‚US-Isreali Binational Science Foundation’ and the ‘German-Israeli Foundation for Scientific Research & Development’ 1993-present Member, German Association of Biochemistry and Molecular Biology 1993-present Reviewer for scientific journals (e.g. Science, EMBO J., J.Biol.Chem.) 2006-present Speaker of the Bioenergetics Section of the German Association of Biochemistry and Molecular Biology (GBM) 2007-present Associate Editor ‘Biological Chemistry’

Honors

Honors and Awards:

1995-2000 Principal investigator within a priority program (SFB) of the german
research foundation (DFG)
1998-2005 Member and chair of a priority program (SPP) of the german research foundation (DFG)
2001-2007 Member of the Research Training Group „Biochemie der Enzyme“ (‚Biochemistry of enzymes’), Albert-Ludwigs-Universität Freiburg
2006-present Coordinator and member of a Collaborative Research Project of the VW-Stiftung
2006-present Member of the ‚Spemann Graduate School of Biology and Medicine’ (former ‚Mobilmed’) of the Exzellenzinitiative des Bundes und der Länder, Albert-Ludwigs-Universität Freiburg (Chair: Prof. Ch. Borner)
2007-present Coordinator and member of the German-French PhD college ‘Membrane Proteins and Biological Membranes’ of the German-French University
2008-present Member of the Research Unit ‘Dynamics of bacterial membrane proteins of the german research foundation (DFG; Chair: Prof. Peter Graumann)
2008-present Coordinator and member of the Trinational Research Training Group ‘Membrane Proteins and Biological Membranes’ of the german research foundation (DFG)

Publications

Selected Publications:

Fraysse-Ailhas, C., Graff, A., Palivan, C.G., Grzelakowski, M., Friedrich, T., Vebert, C., Gescheidt, G. and Meier, W. (2010) Amphiphilic Copolymer membranes promote NADH:Ubiquinone Oxidoreductase activity: Towards an Electron-Transfer Noanodevice. Macromol. Chem. Phys., 211, 229-238. Abstract

Kung, J., Löffler, C., Dörner, K., Heintz, D., Gallien, S., Van Dorsselaer, A, Friedrich, T. and Boll, M. (2009) Identification and characterization of the tungsten-containing class of benzoyl-coenzyme A reductases. Proc. Natl. Acad. Sci USA, 106, 17687-17692. Abstract

Wittekind, C., Schwarz, M., Friedrich, T., and Koslowski, T. (2009) Aromatic Amino Acids as Stepping Stones in Charge Transfer in Respiratory Complex I: An Unusual Mechanism Deduced from Atomistic Theory and Bioinformatics. Am. Chem. Soc. 131, 8134-8140. Abstract

Kohlstädt, M., Dörner, K., Labatzke, R., Koç, C., Hielscher, R., Schiltz, E., Einsle, O., Hellwig, P., and Friedrich, T. (2008) Heterologous production, isolation, characterization and crystallization of a soluble fragment of the NADH:ubiquinone oxidoreductase (complex I) from Aquifex aeolicus. Biochemistry 47, 13036-13045. Abstract

Schneider, D., Pohl, T., Walter, J., Dörner, K., Kohlstädt, M., Berger, A., Spehr, V., and Friedrich, T. (2008) Assembly of the Escherichia coli complex I. Biochim. Biophys. Acta 1777, 735-739. Abstract

Pohl, T., Uhlmann, M., Kaufenstein, M., and Friedrich, T. (2007) Lambda Red-Mediated Mutagenesis and Efficient Large Scale Affinity Purification of the Escherichia coli NADH:Ubiquinone Oxidoreductase (complex I). Biochemistry 46, 10694-10702. Abstract

Flemming, D., Hellwig, P., Lepper, S., Kloer, D.P., and Friedrich, T. (2006) Catalytic Importance of Acidic Amino Acids on Subunit NuoB of the Escherichia coli NADH:Ubiquinone Oxidoreductase (Complex I). J. Biol. Chem. 281, 24781-24789. Abstract

Boxma, B., de Graaf, R.M., van der Staay, G.W.M., van Alen, T.A., Ricard, G., Gabaldon, T., van Hoek, A.H.A.M., Moon-van der Stay, S.Y., Koopman, W.J.H., van Hellemond, J.J., Tielens, A.G.M., Friedrich, T., Veenhuis, M., Huynen, M.A., and Hackstein, J.H.P. (2005) An anaerobic mitochondrion that produces hydrogen. Nature 434, 74-79. Abstract

Stolpe, S. and Friedrich, T. (2004) The Escherichia coli NADH:ubiquinone oxidoreductase (complex I) is a primary proton-pump but may be capable of secondary sodium antiport. Biol. Chem. 279, 18377-18383. Abstract

Friedrich, T. and Böttcher, B. (2004) The gross structure of the respiratory complex I: A Lego-System. Biochim. Biophys. Acta 1608, 1-9. Abstract

SGBM PhD students

SGBM PhD students:

Alumni

Track 1:

Doris Kreuzer-Dekovic (04/2012 - 11/2016)

Marta Vranas (04/2009 - 10/2013)