Nils Wiedemann

Nils Wiedemann Profile Page

Contact

Lab:	Prof. Dr. Nils Wiedemann
Department:	Institute of Biochemistry and Molecular Biology
Phone:	203 5280
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.biochemie.uni-freiburg.de/ag/wiedemann/research
PhD positions available:	YES
Research Area:	Protein Structure and Function
Research Interests:	Mitochondrial biogenesis and sorting of mitochondrial membrane proteins.

CV

Education & Training:	2010: Habilitation, Faculty of Medicine, Albert-Ludwigs-University Freiburg, Germany 2002: Dr. rer. nat., Faculty of Biology, Albert-Ludwigs-University Freiburg, Germany 1996-1997: Master classes in Biochemistry, Cell Biology & Molecular Biology, University of Massachusetts Amherst, USA 1995-1999: Diploma in Chemistry, Albert-Ludwigs-University Freiburg, Germany 1993-1995: Prediploma in Chemistry, Johann Wolfgang Goethe-University Frankfurt, Germany
Employment & Experience:	2013: Academic director, Institute for Biochemistry and Molecular Biology, University of Freiburg 2010: Privatdozent (Habilitation), Faculty of Medicine, University of Freiburg 2006: Visiting Scientist, La Trobe University, Melbourne, Australia 2004-2010: Group leader, Institute for Biochemistry and Molecular Biology, University of Freiburg 2002-2004: Postdoctoral Fellow in Biochemistry, University of Freiburg 2001: Yeast Genetics Course, Cold Spring Harbor Laboratory, USA
Scientific Activities:	Since 2019: Project leader, Centre For Integrative Biological Signalling Studies (CIBSS), Excellence cluster Since 2019: Project leader, Collaborative Research Centre - SFB 1381, "Dynamic Organization of Cellular Protein Machineries: From Biogenesis and Modular Assembly to Function" 2015-2018: Project leader, Collaborative Research Centre - KIDGEM - SFB 1140, "Kidney Disease – From Genes to Mechanisms" 2012-2018: Project leader, Centre For Biological Signalling Studies (BIOSS), Excellence cluster 2000-present: Member of the German Society for Biochemistry and Molecular Biology (GBM), Frankfurt, Germany

Honors

Honors and Awards:

2015: ERC consolidator grant

2011: Eugen-Graetz-Price for Research, Faculty of Medicine, University of Freiburg

2007: Young Investigator Award, German Society for Biochemistry and Molecular Biology (GBM), Frankfurt

2003: Hans Grisebach Award for Dissertation, Faculty of Biology, University of Freiburg

2002: summa cum laude, University of Freiburg

2001: Fellowship of the scientific society Freiburg for participation in the yeast genetics course, Cold Spring Harbor Laboratory, USA

Publications

Selected Publications:

Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell Metab. 2021 Dec 7;33(12):2464-2483.e18. Abstract

Takeda H, Tsutsumi A, Nishizawa T, Lindau C, Busto JV, Wenz LS, Ellenrieder L, Imai K, Straub SP, Mossmann W, Qiu J, Yamamori Y, Tomii K, Suzuki J, Murata T, Ogasawara S, Nureki O, Becker T, Pfanner N, Wiedemann N, Kikkawa M, Endo T. Mitochondrial sorting and assembly machinery operates by β-barrel switching. Nature. 2021 Feb;590(7844):163-169. Abstract

Höhr AIC, Lindau C, Wirth C, Qiu J, Stroud DA, Kutik S, Guiard B, Hunte C, Becker T, Pfanner N, Wiedemann N. Membrane protein insertion through a mitochondrial β-barrel gate. Science. 2018 Jan 19;359(6373):eaah6834. Abstract

Weinhäupl K, Lindau C, Hessel A, Wang Y, Schütze C, Jores T, Melchionda L, Schönfisch B, Kalbacher H, Bersch B, Rapaport D, Brennich M, Lindorff-Larsen K, Wiedemann N, Schanda P. Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space. Cell. 2018 Nov 15;175(5):1365-1379.e25. Abstract

Morgenstern M, Stiller SB, Lübbert P, Peikert CD, Dannenmaier S, Drepper F, Weill U, Höß P, Feuerstein R, Gebert M, Bohnert M, van der Laan M, Schuldiner M, Schütze C, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Cell Rep. 2017 Jun 27;19(13):2836-2852. Abstract

Stiller SB, Höpker J, Oeljeklaus S, Schütze C, Schrempp SG, Vent-Schmidt J, Horvath SE, Frazier AE, Gebert N, van der Laan M, Bohnert M, Warscheid B, Pfanner N, Wiedemann N. Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins. Cell Metab. 2016 May 10;23(5):901-8. Abstract

Qiu J, Wenz LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T. Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell. 2013 Aug 1;154(3):596-608. Abstract

Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud DA, Kulawiak B, Wirth C, Zahedi RP, Dolezal P, Wiese S, Simon O, Schulze-Specking A, Truscott KN, Sickmann A, Rehling P, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N. Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane. Mol Cell. 2011 Dec 9;44(5):811-8. Abstract

Kutik S, Stojanovski D, Becker L, Becker T, Meinecke M, Krüger V, Prinz C, Meisinger C, Guiard B, Wagner R, Pfanner N, Wiedemann N. Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell. 2008 Mar 21;132(6):1011-24. Abstract

Wiedemann N, Kozjak V, Chacinska A, Schönfisch B, Rospert S, Ryan MT, Pfanner N, Meisinger C. Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature. 2003 Jul 31;424(6948):565-71. Abstract