Georgios Pyrowolakis

Georgios Pyrowolakis Profile Page

Contact

Lab:	Dr. Giorgos Pyrowolakis
Department:	Developmental Biology Unit, Biology I and CIBSS
Address:	Hilde-Mangold Haus Habsburgerstr. 49 79104 Freiburg
Phone:	+49 761 203 8459
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.bioss.uni-freiburg.de/dr-giorgos-pyrowolakis/
PhD positions available:	YES
Research Area:	Developmental Biology
Research Interests:	- Signaling - Integration of Signaling - BMP/TGFß-Signaling - Stem Cells - Tissue and organ Development Development - Morphogen Gradients

CV

Education & Training:

1989 Lyceum Diploma, 3rd Lyceum Iraklio, Crete, Greece
1990 - 1992 Studies of Biology, University of Mainz
1992 - 1995 Studies of Biology, University of Heidelberg
1995 - 1996 Diploma thesis in the lab of Prof. Dr. R. Herrmann, Center of Molecular Biology Heidelberg (ZMBH), University of Heidelberg
1996 - 1998 Ph.D. student in the group of Prof. Dr. S. Jentsch, Center of Molecular Biology Heidelberg (ZMBH), University of Heidelberg
1998 - 2000 Continuation of the Ph.D. thesis in the same group at the Max-Planck-Institute of Biochemistry, Martinsried, Munich
August 2000 Ph.D. from the University of Heidelberg

Employment & Experience:

2002 - 2006 Postdoctoral fellow in the group of Prof. Dr. M. Affolter, Biozentrum, University of Basel, Switzerland
Since Sept. 2006 Junior Group leader at the Institute for Biology I, University of Freiburg

Honors

Honors and Awards:

2000 Ph.D. thesis awarded with "summa cum laude"

2002 Roche Research Foundation Fellow

2003 EMBO Long-term fellow Since

2006 Junior group leader SFB592

Publications

Selected Publications:

Vigano MA, Ell CM, Kustermann MMM, Aguilar G, Matsuda S, Zhao N, Stasevich TJ, Affolter M, Pyrowolakis G. Protein manipulation using single copies of short peptide tags in cultured cells and in Drosophila melanogaster. Development. 2021 Mar 16;148(6):dev191700. Abstract

Chayengia M, Veikkolainen V, Jevtic M, Pyrowolakis G. Sequence environment of BMP-dependent activating elements controls transcriptional responses to Dpp signaling in Drosophila. Development. 2019 Jun 12;146(11):dev176107. Abstract

Tracy Cai X, Li H, Safyan A, Gawlik J, Pyrowolakis G, Jasper H. AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis. Nat Commun. 2019 Jul 5;10(1):2988. Abstract

Norman M, Vuilleumier R, Springhorn A, Gawlik J, Pyrowolakis G. Pentagone internalises glypicans to fine-tune multiple signalling pathways. Elife. 2016 Jun 8;5:e13301. Abstract

Beira JV, Springhorn A, Gunther S, Hufnagel L, Pyrowolakis G, Vincent JP. The Dpp/TGFβ-dependent corepressor Schnurri protects epithelial cells from JNK-induced apoptosis in drosophila embryos. Dev Cell. 2014 Oct 27;31(2):240-7. Abstract

Ben-Zvi D, Pyrowolakis G, Barkai N, Shilo BZ. Expansion-repression mechanism for scaling the Dpp activation gradient in Drosophila wing imaginal discs. Curr Biol. 2011 Aug 23;21(16):1391-6. Abstract

Vuilleumier R, Springhorn A, Patterson L, Koidl S, Hammerschmidt M, Affolter M, Pyrowolakis G. Control of Dpp morphogen signalling by a secreted feedback regulator. Nat Cell Biol. 2010 Jun;12(6):611-7. Abstract

Weiss A, Charbonnier E, Ellertsdóttir E, Tsirigos A, Wolf C, Schuh R, Pyrowolakis G, Affolter M. A conserved activation element in BMP signaling during Drosophila development. Nat Struct Mol Biol. 2010 Jan;17(1):69-76. Abstract

Pyrowolakis G, Hartmann B, Müller B, Basler K, Affolter M. A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev Cell. 2004 Aug;7(2):229-40. Abstract

Müller B, Hartmann B, Pyrowolakis G, Affolter M, Basler K. Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell. 2003 Apr 18;113(2):221-33. Abstract

SGBM PhD students

SGBM PhD students:

Clara-Maria Ell (since November 2018)

Alumni

Jennifer Gawlik (03/2014-06/2021)

Milica Jevtic (04/2010 - 04/2014)

Alexander Springhorn (09/2008 - 11/2013)