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Contact
| Lab: | Prof. Dr. Georg Haecker |
| Department: | Institute for Medical Microbiology and Hygiene |
| Address: | Hermann-Herder-Str. 11 79104 Freiburg |
| Phone: | 203 6531 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | www.uniklinik-freiburg.de/mikrobiologie/live/forschung-1/haecker.html |
| PhD positions available: | YES |
| Research Area: | Immunology and Virology |
| Research Interests: | Molecular and Cellular Immunology |
CV
| Education & Training: | 1990 Medical Examination 1991 Dr. med. at University of Ulm 1992 Foreign Medical Graduates Examination in Medical Sciences 1998 Dr. med. habil. Habilitation in Medical Microbiology, Immunology |
| Employment & Experience: | 1992-1993 Resident Doctor / Scientist Inst. f. Med. Microbiology TUM 1993-1995 Visiting Scientist, Walter and Eliza Hall Inst. f. Med. Research, Melbourne, Australia (Scholarship from the German Research Coundil, DFG) 1995 Research Officer, Walter and Eliza Hall Inst. f. Med. Research, Melbourne, Australia 1996-1998 Resident Doctor / Scientist, Inst. f. Med. Microbiology, TUM 1997 Consultant (Medical Microbiology) for the University Hospital of the TUM 1998-2000 Privatdozent (Lecturer) Inst. f. Med. Microbiology of the TUM 2000-2009 Professor, Inst. f. Med. Microbiology, Immunology and Hygiene, TUM 07/2009 Full professor and Chair, Dep. of. Med. Microbiology and Hygiene, University Freiburg |
| Scientific Activities: | Ad hoc reviewer for scientific journals (J Exp Med, EMBO J, J Cell Biol, J Immunol and others). Ad hoc reviewer for funding organisations (DFG, NSF, Wellcome Trust, Human Frontier Science Program, Wilhelm Sander-Stiftung and others). Academic Editor, PLoSONE |
Honors
| Honors and Awards: | DFG overseas fellowship 1993 - 1995. |
Publications
| Selected Publications: | Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Häcker G. (2016) The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. EMBO Rep., 17(5):724-38. Abstract Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., Schmitt-Graeff, A., Freudenberg, M., von Loewenich, F. D., Wolf, P., Leonhardt, F., Baxan, N., Pfeifer, D., Schmah, O., Schönle, A:, Martin, S. F., Mertelsmann, R., Duyster, J., Finke, J., Prinz, M., Henneke, P, Häcker, H., Hildebrandt, G. C.*, Häcker, G.*, Zeiser, R.* (2014) Neutrophil granulocytes recruited upon translocation of intestinal commensal bacteria enhance graft-versus-host disease via tissue damage. Nat. Med., 20(6):648-54. *Equal contribution. Abstract Gentle, I.E., Moelter, I., Lechler, N., Bambach, S., Vucikuja, S., Häcker, G.* and Aichele, P.* (2014) Inhibitor of Apoptosis Proteins are required for effective T cell expansion/survival during anti-viral immunity in mice. Blood, 123(5):659-68. *Equal contribution. Abstract Eitz Ferrer, P., Potthoff, S., Kirschnek, S., Gasteiger, G., Kastenmüller, W., Ludwig, H., Paschen, S., Villunger, A., Sutter, G., Drexler, I. and Häcker, G. (2011) Induction of Noxa-mediated apoptosis by Modified Vaccinia Virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. PLoS Path., 7(6):e1002083. Abstract Feoktistova, S., Geserick, P., Kellert, B, Panayotova Dimitrova, D., Langlais, C., Hupe, M., Cain, K., MacFarlane, M., Häcker, G. and Leverkus, M. (2011) cIAPs block Ripoptosome formation, a RIP1/caspase 8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell, 43(3):449-63. Abstract Paschen, S., Christian, J. G., Vier, J., Schmidt, F., Walch, A., Ojcius, D. M. and Häcker. G. (2008) Cytopathicity of Chlamydia infection can be largely reproduced by expressing a single chlamydial gene, Chlamydial Protease-like Activity Factor. J Cell Biol, 182(1):117-27. Abstract Weber, A., Paschen, S. A., Heger, K., Wilfling, F., Frankenberg, T., Bauerschmitt, H., Seiffert, B. M., Kirschnek, S., Wagner, H. and Häcker, G. (2007) BimS Induced Apoptosis Requires Mitochondrial Localization but not Interaction with Anti-Apoptotic Bcl-2 Proteins. J Cell Biol. 177(4):625-36. Abstract Bauer, A., Villunger, A., Labi, V., Fischer, S.F., Erlacher, M., Strasser, A., Wagner, H., Schmid, R.M. and Häcker, G. (2006) The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci USA, 103:10979-84. Abstract Häcker. H., Redecke, V., Blagoev, B., Kratchmarova, I., Wang, G., Kamps, M.P., Saha, S.K., Oganesyan, G., Raz, E., Wagner, H., Häcker, G., Mann, M., Cheng, G. and Karin, M. (2006) Specificity in TLR Signaling: Activation of the Interferon Response Depends on TRAF3. Nature, 439:204-207. Abstract Fischer, S.F., Vier, J., Kirschnek, S., Klos, A., Hess, S., Ying, S. and Häcker, G. (2004) Chlamydia inhibit host cell apoptosis by degradation of pro-apoptotic BH3-only proteins. J Exp Med., 200:905-16. Abstract |
SGBM PhD students
| SGBM PhD students: |
Alumni Track 1: Daniel Frank (05/2011 - 06/2015) Sanjivan Gautam (11/2009 - 08/2013)
Track 2: Prafull Kumar Singh (09/2014 - 07/2017) |
