Georg Haecker

Georg Haecker Profile Page

Contact

Lab:	Prof. Dr. Georg Haecker
Department:	Institute for Medical Microbiology and Hygiene
Address:	Hermann-Herder-Str. 11 79104 Freiburg
Phone:	203 6531
E-mail:	This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:	www.uniklinik-freiburg.de/mikrobiologie-en/scientificresearch/ag-prof-haecker.html
PhD positions available:	YES
Research Area:	Immunology and Virology
Research Interests:	Molecular and Cellular Immunology

CV

Education & Training:	1990 Medical Examination 1991 Dr. med. at University of Ulm 1992 Foreign Medical Graduates Examination in Medical Sciences 1998 Dr. med. habil. Habilitation in Medical Microbiology, Immunology
Employment & Experience:	1992-1993 Resident Doctor / Scientist Inst. f. Med. Microbiology TUM 1993-1995 Visiting Scientist, Walter and Eliza Hall Inst. f. Med. Research, Melbourne, Australia (Scholarship from the German Research Coundil, DFG) 1995 Research Officer, Walter and Eliza Hall Inst. f. Med. Research, Melbourne, Australia 1996-1998 Resident Doctor / Scientist, Inst. f. Med. Microbiology, TUM 1997 Consultant (Medical Microbiology) for the University Hospital of the TUM 1998-2000 Privatdozent (Lecturer) Inst. f. Med. Microbiology of the TUM 2000-2009 Professor, Inst. f. Med. Microbiology, Immunology and Hygiene, TUM 07/2009 Full professor and Chair, Dep. of. Med. Microbiology and Hygiene, University Freiburg
Scientific Activities:	Ad hoc reviewer for scientific journals (J Exp Med, EMBO J, J Cell Biol, J Immunol and others). Ad hoc reviewer for funding organisations (DFG, NSF, Wellcome Trust, Human Frontier Science Program, Wilhelm Sander-Stiftung and others). Academic Editor, PLoSONE

Honors

Honors and Awards:

DFG overseas fellowship 1993 - 1995.
Grants awarded: 29 (DFG (SFB or direct proposal), Deutsche Krebshilfe, Wilhelm Sander-Stiftung, Else Kröner-Fresenius-Stiftung, EU/BMBF, Deutsche Jose Carreras-Stiftung) totalling approx. 4.5 Mio EUR.

Publications

Selected Publications:

Singh PK, Roukounakis A, Weber A, Das KK, Sohm B, Villunger A, Garcia-Saez AJ, Häcker G. Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim. Cell Death Differ. 2020 Feb;27(2):434-450. Abstract

Hülsdünker J, Thomas OS, Haring E, Unger S, Gonzalo Núñez N, Tugues S, Gao Z, Duquesne S, Cywes-Bentley C, Oyardi O, Kirschnek S, Schmitt-Graeff A, Pabst O, Koenecke C, Duyster J, Apostolova P, Blaser MJ, Becher B, Pier GB, Häcker G, Zeiser R. Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20700-20706. Abstract

Brokatzky D, Dörflinger B, Haimovici A, Weber A, Kirschnek S, Vier J, Metz A, Henschel J, Steinfeldt T, Gentle IE, Häcker G. A non-death function of the mitochondrial apoptosis apparatus in immunity. EMBO J. 2019 Jun 3;38(11):e100907. Abstract

Hülsdünker J, Ottmüller KJ, Neeff HP, Koyama M, Gao Z, Thomas OS, Follo M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lämmermann T, Blaser MJ, Fife BT, Blazar BR, Beilhack A, Hill GR, Häcker G, Zeiser R. Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset. Blood. 2018 Apr 19;131(16):1858-1869. Abstract

Singh PK, Roukounakis A, Frank DO, Kirschnek S, Das KK, Neumann S, Madl J, Römer W, Zorzin C, Borner C, Haimovici A, Garcia-Saez A, Weber A, Häcker G. Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis. Genes Dev. 2017 Sep 1;31(17):1754-1769. Abstract

Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Häcker G. The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. EMBO Rep. 2016 May;17(5):724-38. Abstract

Schwab L, Goroncy L, Palaniyandi S, Gautam S, Triantafyllopoulou A, Mocsai A, Reichardt W, Karlsson FJ, Radhakrishnan SV, Hanke K, Schmitt-Graeff A, Freudenberg M, von Loewenich FD, Wolf P, Leonhardt F, Baxan N, Pfeifer D, Schmah O, Schönle A, Martin SF, Mertelsmann R, Duyster J, Finke J, Prinz M, Henneke P, Häcker H, Hildebrandt GC, Häcker G, Zeiser R. Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage. Nat Med. 2014 Jun;20(6):648-54. Abstract

Gentle IE, Moelter I, Lechler N, Bambach S, Vucikuja S, Häcker G, Aichele P. Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice. Blood. 2014 Jan 30;123(5):659-68. Abstract

Eitz Ferrer P, Potthoff S, Kirschnek S, Gasteiger G, Kastenmüller W, Ludwig H, Paschen SA, Villunger A, Sutter G, Drexler I, Häcker G. Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. PLoS Pathog. 2011 Jun;7(6):e1002083. Abstract

Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, Cain K, MacFarlane M, Häcker G, Leverkus M. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell. 2011 Aug 5;43(3):449-63. Abstract

SGBM PhD students

SGBM PhD students:

Alumni

Daniel Frank (05/2011 - 06/2015)

Sanjivan Gautam (11/2009 - 08/2013)

Prafull Kumar Singh (09/2014 - 07/2017)